ASEAN cosmetic ingredient regulations

2,6-Bis(2-hydroxyethoxy)-3,5-pyridinediamine and its HCl salt,

CAS 117907-42-3

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1215 · version 2026-1 · source checked 2026-08-30

2,6-Di-Tert-Butyl-4-Methylphenol Butylated Hydroxytoluene 128-37-0

CAS 128-37-0 · EC 204-881-4

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: a) Mouthwash b) Toothpaste c) Other leave-on and rinse- off products · a) 0.001 % b) 0.1 % c) 1 %

Source:ASEAN Annex III, reference 342 · version 2026-1 · source checked 2026-08-30

2,6-Dibromo-4-cyanophenyl octanoate

CAS 1689-99-2

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1032 · version 2026-1 · source checked 2026-08-30

2,6-Dihydroxy-4-methyl-benzaldehyde (atranol)

CAS 526-37-4

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1381 · version 2026-1 · source checked 2026-08-30

2,6-Dihydroxy-4-methylpyridine and its salts, when used as a

CAS 4664-16-8

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1245 · version 2026-1 · source checked 2026-08-30

2,6-Dimethoxy-3,5-pyridinediamine and its hydrochloride 2,6-Dimethoxy-3,5-pyridinediamine 2,6-Dimethoxy-3,5-pyridinediamine HCl CAS No 56216-28-5 / CAS No 85679- 78-3

CAS 56216-28-5; 85679-78-3 · EC 260-062-1

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25 % (as hydrochloride) The direction for use “wear suitable gloves” must be included in label or leaflet text. · To be printed on the label. The mixing ratio. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 238 · version 2026-1 · source checked 2026-08-30

2,6-Dimethyl-1,3-dioxan-4-yl acetate (Dimethoxane)

CAS 828-00-2

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 368 · version 2026-1 · source checked 2026-08-30

2,6-Dinitrotoluene

CAS 606-20-2

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 692 · version 2026-1 · source checked 2026-08-30

2,6-Pyridinediamine, 3-(3- pyridinylazo) 2,6-Diamino-3- ((Pyridine-3-yl) azo)Pyridine CAS No 28365-08-4

CAS 28365-08-4 · EC 421-430-9

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: (a) Hair dye substance in oxidative hair dye products b) Hair dye substance in non- oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · (b) 0.25 % · (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25 % (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text. · (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past. (a) and (b) Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 301 · version 2026-1 · source checked 2026-08-30

2,7-Naphthalenedisulfonic acid, 5-(acetylamino)-4-hydroxy-3-((2-

CAS 6441-93-6 · EC 229-231-7

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1295 · version 2026-1 · source checked 2026-08-30

2-(2-Aminoethylamino)ethanol; (AEEA)

CAS 111-41-1 · EC 203-867-5

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1471 · version 2026-1 · source checked 2026-08-30

2-(2-Methoxyethoxy)ethanol

CAS 111-77-3 · EC 203-906-6

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1000 · version 2026-1 · source checked 2026-08-30

2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)benzoic acid;

CAS 15086-94-9; 17372-87-1; 15876-39-8 · EC 240-005-7

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1334 · version 2026-1 · source checked 2026-08-30

2-(4-Allyl-2-methoxyphenoxy)-N,N-diethylacetamide and its salts

CAS 305-13-5

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 224 · version 2026-1 · source checked 2026-08-30

2-(4-Amino-3-nitroanilino)ethanol HC Red No 7 CAS No 24905-87-1

CAS 24905-87-1 · EC 246-521-9

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair dye substance in non- oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · 1.0 % · • Do not use with nitrosating agents • Maximum nitrosamine content: 50µg/kg(21) • Keep in nitrite-free containers. Indonesia only: Not permitted The direction for use “wear suitable gloves” must be included in label or leaflet text. · Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 266 · version 2026-1 · source checked 2026-08-30

2-(4-Methyl-2-nitroanilino)ethanol Hydroxyethyl-2-Nitro-p-Toluidine CAS No 100418-33-5

CAS 100418-33-5 · EC 408-090-7

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · (b) 1.0% · (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.0% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50µg/kg(21) • Keep in nitrite-free containers. The direction for use “wear suitable gloves” must be included in label or leaflet text. · (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary “black henna” tattoo in the past (a) and (b) Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 277 · version 2026-1 · source checked 2026-08-30

2-(4-tert-Butylphenyl)ethanol

CAS 5406-86-0

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1071 · version 2026-1 · source checked 2026-08-30

2-(4-tert-butylbenzyl) propionaldehyde

CAS 80-54-6 · EC 201-289-8

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1666 · version 2026-1 · source checked 2026-08-30

2-(6-Hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid; Fluorescein

CAS 2321-07-5; 518-47-8 · EC 219-031-8

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1332 · version 2026-1 · source checked 2026-08-30

2-(ethoxyethoxy)-ethanol Diethylene glycol monoethyl ether (DEGEE) Ethoxydiglycol CAS No 111-90-0

CAS 111-90-0 · EC 203-919-7

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: (a) Oxidative hair dye products (b) Non-oxidative hair dye products (c) Rinse-off products other than hair dye products (d) Other non-spray cosmetic products (e) The following spray products: fine fragrances, hairsprays, anti-perspirants and deodorants. · (a) 7% (b) 5% (c) 10% (d) 2.6% (e) 2.6% · (a) to (e): The level of ethylene glycol impurity in Ethoxydiglycol must be ≤0.1% Not to be used in eye products and oral products.

Source:ASEAN Annex III, reference 312 · version 2026-1 · source checked 2026-08-30

2-Acetoxyethyltrimethylammonium hydroxide (acetylcholine) and its salts

CAS 51-84-3

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 2 · version 2026-1 · source checked 2026-08-30

2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts

CAS 5934-19-0

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 29 · version 2026-1 · source checked 2026-08-30

2-Amino-3-nitrophenol and its salts, when used as a substance

CAS 603-85-0 · EC 210-060-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1317 · version 2026-1 · source checked 2026-08-30

2-Amino-4,6-dinitrop henol and 2- amino-4,6-dinitrophe nol, sodium salt Picramic Acid And Sodium Picramate CAS No 96-91-3 / 831-52-7

CAS 96-91-3; 831-52-7 · EC 202-544-6

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · (b) 0.6 % · (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.6 % (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text. · (a) To be printed on the label: The mixing ratio. “Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.” (a) and (b) Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 280 · version 2026-1 · source checked 2026-08-30

2-Amino-4-nitrophenol

CAS 99-57-0 · EC 202-767-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 383 · version 2026-1 · source checked 2026-08-30

2-Amino-5-nitrophenol

CAS 121-88-0

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 384 · version 2026-1 · source checked 2026-08-30

2-Amino-6-chloro-4-nitrophenol 2-Amino-6-chloro-4-nitrophenol CAS No 6358-09-4

CAS 6358-09-4 · EC 228-762-1

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · (b) 2.0 % · (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0 % (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text. · (a) To be printed on the label: The mixing ratio Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary “black henna” tattoo in the past (a) and (b) Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 252 · version 2026-1 · source checked 2026-08-30

2-Aminomethyl-p-aminophenol and its HCl salt, when used as a

CAS 79352-72-0

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1230 · version 2026-1 · source checked 2026-08-30

2-Aminophenol (o-Aminophenol; CI 76520) and its salts

CAS 95-55-6 · EC 202-431-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1372 · version 2026-1 · source checked 2026-08-30

2-Aminopyridin-3-ol 2-Amino-3-Hydroxypyridine CAS No 16867-03-1

CAS 16867-03-1 · EC 240-886-8

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.0% The direction for use “wear suitable gloves” must be included in label or leaflet text. · The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 261 · version 2026-1 · source checked 2026-08-30

2-Benzyl-2-dimethylamino-4'- morpholinobutyrophenone

CAS 119313-12-1 · EC 404-360-3

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1614 · version 2026-1 · source checked 2026-08-30

2-Bromopropane

CAS 75-26-3

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 644 · version 2026-1 · source checked 2026-08-30

2-Butanone oxime

CAS 96-29-7

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1124 · version 2026-1 · source checked 2026-08-30

2-Butyryl-3-hydroxy-5-thiocyclohexan-3-yl-cyclohex-2-en-1-one

CAS 94723-86-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1479 · version 2026-1 · source checked 2026-08-30

2-Chloracetamide

CAS 79-07-2 · EC 201-174-2

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1387 · version 2026-1 · source checked 2026-08-30

2-Chloro-5-nitro-N-hydroxyethyl-p-phenylenediamine and its

CAS 50610-28-1 · EC 256-652-3

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1318 · version 2026-1 · source checked 2026-08-30

2-Chloro-6-fluoro-phenol

CAS 2040-90-6

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1477 · version 2026-1 · source checked 2026-08-30

2-Chloro-6-methylpyrimidin-4-yldimethylamine; (crimidine-ISO)

CAS 535-89-7

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 83 · version 2026-1 · source checked 2026-08-30

2-Cyano-3,3-diphenyl acrylic acid, 2-ethylhexyl ester (Octocrylene)(6) CAS No. 6197-30-4

CAS 6197-30-4 · EC 228-250-8

ASEAN Annex VII lists this record among UV filters allowed for cosmetic use. Member-state transition rules and deviations still require local verification.

Conditions: a) 9 % b) 10 % · a) Propellant spray products b) Other products

Source:ASEAN Annex VII, reference 10 · version 2026-1 · source checked 2026-08-30

2-Diethylaminoethyl 3-hydroxy-4-phenylbenzoate and its salts

CAS 3572-52-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 128 · version 2026-1 · source checked 2026-08-30

2-Ethoxyethanol

CAS 110-80-5 · EC 203-804-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 666 · version 2026-1 · source checked 2026-08-30

2-Ethoxyethyl acetate

CAS 111-15-9 · EC 203-839-2

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 673 · version 2026-1 · source checked 2026-08-30

2-Ethylhexanoic acid and its salts

CAS 149-57-5

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1024 · version 2026-1 · source checked 2026-08-30

2-Ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-

CAS 57583-35-4

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1567 · version 2026-1 · source checked 2026-08-30

2-Ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-

CAS 15571-58-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1556 · version 2026-1 · source checked 2026-08-30

2-Ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-

CAS 57583-34-3

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1555 · version 2026-1 · source checked 2026-08-30

2-Ethylhexyl salicylate (Octyl Salicylate) CAS No. 118-60-5

CAS 118-60-5 · EC 204-263-4

ASEAN Annex VII lists this record among UV filters allowed for cosmetic use. Member-state transition rules and deviations still require local verification.

Conditions: 5%

Source:ASEAN Annex VII, reference 20 · version 2026-1 · source checked 2026-08-30

2-Ethylhexyl-2-ethylhexanoate

CAS 7425-14-1 · EC 231-057-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1491 · version 2026-1 · source checked 2026-08-30

2-Ethylhexyl[[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-

CAS 80387-97-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 680 · version 2026-1 · source checked 2026-08-30

2-Ethylphenylhydrazine hydrochloride

CAS 19398-06-2

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1514 · version 2026-1 · source checked 2026-08-30