What does the restriction note for 2-AMINO-4-NITROPHENOL mean?

The restriction field for 2-AMINO-4-NITROPHENOL reads: II/383. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 99-57-0?

CAS 99-57-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains 2-AMINO-4-NITROPHENOL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8449015/10/2010

2-AMINO-4-NITROPHENOL

2-AMINO-4-NITROPHENOL is linked to 1 EU annex record on this page. Inventory note: II/383.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Evidence linked Prohibited Open this evidence	1	English and French
New Zealand	Evidence linked Prohibited Open this evidence	1	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Evidence linked Prohibited Open this evidence	1	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Prohibited Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Evidence linked Prohibited Open this evidence	1	Portuguese with INCI crosswalks
India	Evidence linked Prohibited Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 99-57-0

CAS 99-57-0PubChem CID 3613389

2-Amino-4-Nitrophenol

2-Amino-4-nitrophenol is a member of 4-nitrophenols. — ChEBI

IUPAC name: 2-amino-4-nitrophenol

Molecular formula: C6H6N2O3
Molecular weight: 154.12 g/mol
Exact mass: 154.03784206 Da
XLogP3: 1.5
Topological polar surface area: 92.1 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

2-Hydroxy-5-nitroaniline4-Nitro-2-aminophenolPhenol, 2-amino-4-nitro-p-Nitro-o-aminophenolRodol 424-Nitro-2-aminofenol1-Amino-2-hydroxy-5-nitrobenzene1-Hydroxy-2-amino-4-nitrobenzene

16 more reported names

3-Amino-4-hydroxynitrobenzeneNCI-C559585-Nitro-2-hydroxyanilineC.I. 76530CI 76530G501UCI6T94-nitro-2-amino-1-hydroxybenzeneNSC-4664DTXCID00622-amino-p-nitrophenolRefChem:85223202-767-9p-Nitroaminofenol2-Amino-4-nitro-phenol1-Nitro-3-amino-4-hydroxybenzene2-Amino-4-nitrofenol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:82383
ChEMBL:CHEMBL316992
EPA DTXSID:DTXSID6020062
PubMed:28321044
PubMed:22590392
PubMed:22227702
PubMed:21962688
PubMed:21754773
PubMed:21587534
PubMed:21582157
PubMed:21581902
PubMed:20086194
PubMed:18550424
PubMed:18280784
PubMed:17389084

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 2-AMINO-4-NITROPHENOL

INCI name

2-AMINO-4-NITROPHENOL

Record provenance

Inventory reference: 84490
Imported identity: 2-AMINO-4-NITROPHENOL
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for 2-AMINO-4-NITROPHENOL

Annex II Restriction reference

Entry 383

2-Amino-4-nitrophenol

CAS: 99-57-0

EC: 202-767-9

Key data

CAS

99-57-0

202-767-9

Restriction

II/383

Function

HAIR DYEING: Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#191 · 2-AMINO-4-NITROPHENOL

Ingredients with overlapping formulation functions

2-AMINO-3-HYDROXYPYRIDINEHAIR DYEING

2-AMINO-3-NITROPHENOLHAIR DYEING

2-AMINO-4-HYDROXYETHYLAMINOANISOLEHAIR DYEING

2-AMINO-4-HYDROXYETHYLAMINOANISOLE SULFATEHAIR DYEING

2-AMINO-4-NITROPHENOL SULFATEHAIR DYEING

2-AMINO-5-ETHYLPHENOL HCLHAIR DYEING

2-AMINO-5-NITROPHENOLHAIR DYEING

2-AMINO-6-CHLORO-4-NITROPHENOLHAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How 2-AMINO-4-NITROPHENOL appears in the CosIng inventory

The CosIng inventory lists 2-AMINO-4-NITROPHENOL as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

2-AMINO-4-NITROPHENOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

2-AMINO-4-NITROPHENOL appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for 2-AMINO-4-NITROPHENOL reads: "II/383". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, 2-AMINO-4-NITROPHENOL carries the following function designation(s):

HAIR DYEING

CAS 99-57-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for 2-AMINO-4-NITROPHENOL

This page combines the CosIng inventory entry for 2-AMINO-4-NITROPHENOL with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research 2-AMINO-4-NITROPHENOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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