ASEAN cosmetic ingredient regulations

1–Methoxy-2,5-diaminobenzene (2,5-Diaminoanisole) and their

CAS 5307-02-8

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 377 · version 2026-1 · source checked 2026-08-30

2',4',5',7'-Tetraiodofluorescein , its disodium salt (Acid Red 51;

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1337 · version 2026-1 · source checked 2026-08-30

2,2'-Bioxirane

CAS 1464-53-5

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 662 · version 2026-1 · source checked 2026-08-30

2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane

CAS 70-30-4

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 371 · version 2026-1 · source checked 2026-08-30

2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)bis[N-(2,4-

CAS 5102-83-0

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1351 · version 2026-1 · source checked 2026-08-30

2,2'-[(4-Amino-3-nitrophenyl) imino]bisethanol and its hydrochloride HC Red No 13 CAS No 29705-39-3/94158-13-1

CAS 29705-39-3; 94158-13-1 · EC 303-083-4

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · (b) 2.5% (as hydrochloride) · (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.25 % (as hydrochloride) (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text. · (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary “black henna” tattoo in the past (a) & (b) Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 237 · version 2026-1 · source checked 2026-08-30

2,2'-[Cyclohexylidenebis[(2-methyl-4,1-phenylene)azo]]bis[4-

CAS 6706-82-7

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1352 · version 2026-1 · source checked 2026-08-30

2,2,2-Tribromoethanol (tribromoethyl alcohol)

CAS 75-80-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 326 · version 2026-1 · source checked 2026-08-30

2,2,2-Trichloroethane-1,1–diol

CAS 302-17-0

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 77 · version 2026-1 · source checked 2026-08-30

2,2,6-Trimethyl-4-piperidyl benzoate (benzamine) and its salts

CAS 500-34-5

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 51 · version 2026-1 · source checked 2026-08-30

2,2-Dibromo-2-nitroethanol

CAS 69094-18-4

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1090 · version 2026-1 · source checked 2026-08-30

2,2-bis(bromomethyl) propane-1,3-diol

CAS 3296-90-0

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1665 · version 2026-1 · source checked 2026-08-30

2,2-dimethylpropan-1-ol,tribromo derivative; 3-bromo-2,2-

CAS 36483-57-5

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1700 · version 2026-1 · source checked 2026-08-30

2,2’(1,2-Ethenediyl)bis[5-((4-ethoxyphenyl)azo]benzenesulfonic

CAS 2870-32-8 · EC 220-698-2

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1264 · version 2026-1 · source checked 2026-08-30

2,2’-((3,3’,5,5’-Tetramethyl-(1,1’-biphenyl)-4,4’-diyl)-

CAS 85954-11-6

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1390 · version 2026-1 · source checked 2026-08-30

2,2’-((3-Chloro-4-((2,6-dichloro-4-

CAS 23355-64-8 · EC 245-604-7

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1260 · version 2026-1 · source checked 2026-08-30

2,2’-(Nitrosoimino)bisethanol

CAS 1116-54-7

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 704 · version 2026-1 · source checked 2026-08-30

2,2’-Methylene-bis(6-(2H-benzotriazol-2-yl)-4- (tetramethyl-butyl)-1,1,3,3-phenol);2,2’- Methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3- tetramethylbutyl)phenol) (Methylene Bis- Benzotriazolyl Tetramethylbutylphenol (nano)/MBBT (nano)) CAS No. 103597-45-1

2,2’-Methylene-bis(6-(2H-benzotriazol-2-yl)-4- (tetramethyl-butyl)-1,1,3,3-phenol);2,2’- Methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3- tetramethylbutyl)phenol) (Methylene Bis- Benzotriazolyl Tetramethylbutylphenol (nano)/MBBT (nano)) CAS No. 103597-45

CAS 103597-45-1 · EC 403-800-1

ASEAN Annex VII lists this record among UV filters allowed for cosmetic use. Member-state transition rules and deviations still require local verification.

Conditions: 10%(5) · Not to be used in applications that may lead to exposure of the end user's lungs by inhalation. Only nanomaterials having the following characteristics are allowed: - Purity ≥ 98.5 %, with 2,2′- methylene-bis-(6(2H- benzotriazol-2-yl)-4- (isooctyl)phenol) isomer fraction not exceeding 1.5 %; - Solubility < 5 ng/L in water at 25 °C; - Partition coefficient (Log Pow): 12.7 at 25 °C; - Uncoated; - Median particle size D50 (50% of number below this diameter): ≥ 120 nm of mass distribution and/or ≥ 60 nm of number size distribution.

Source:ASEAN Annex VII, reference 23a · version 2026-1 · source checked 2026-08-30

2,2’-Methylene-bis(6-(2H-benzotriazol-2-yl)-4- (tetramethyl-butyl)-1,1,3,3-phenol);2,2’- Methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3- tetramethylbutyl)phenol) (Methylene Bis- Benzotriazolyl Tetramethylbutylphenol/MBBT) CAS No. 103597-45-1

CAS 103597-45-1 · EC 403-800-1

ASEAN Annex VII lists this record among UV filters allowed for cosmetic use. Member-state transition rules and deviations still require local verification.

Conditions: 10%(5)

Source:ASEAN Annex VII, reference 23 · version 2026-1 · source checked 2026-08-30

2,2’-[(3,3’-dichloro[1,1’biphenyl]-4,4’-diyl)bis(azo)]bis[3-oxo-N-

CAS 6358-85-6 · EC 228-787-8

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1263 · version 2026-1 · source checked 2026-08-30

2,2′-[(4-Aminophenyl)) imino] bis (ethanol) sulphate N,N-bis (2-Hydroxyethyl)- p- Phenylenediamine Sulfate CAS No 54381-16-7

CAS 54381-16-7 · EC 259-134-5

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,5 % (calculated as sulphate) - Do not use with nitrosating agents - Maximum nitrosamine content: 50 μg/kg (21) - Keep in nitrite-free containers The direction for use “wear suitable gloves” must be included in label or leaflet text. · The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows Indonesia only: "Rinse the eyes immediately if product comes into contact with them because it can cause irritation”.

Source:ASEAN Annex III, reference 253 · version 2026-1 · source checked 2026-08-30

2,2′-[[4-[(2-Hydroxyethyl)amino]-3- nitrophenyl]imino]bisethanol HC Blue No 2 CAS No 33229-34-4

CAS 33229-34-4 · EC 251-410-3

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair dye substance in non- oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · 2.8% · • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg(21) • Keep in nitrite-free containers The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use “wear suitable gloves” must be included in label or leaflet text. · Can cause allergic reaction Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 199 · version 2026-1 · source checked 2026-08-30

2,3,4-Trichlorobut-1-ene

CAS 2431-50-7

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1051 · version 2026-1 · source checked 2026-08-30

2,3,7,8,-Tetrachlorodibenzo-p-dioxin

CAS 1746-01-6

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 367 · version 2026-1 · source checked 2026-08-30

2,3-Diamino-6,7- dihydro-1H,5H- pyrazolo[1,2-a] Pyrazol-1-one dimethanesulfonate 2,3-Diaminodihydropyrazolo pyrazolone Dimethosulfonate CAS No 857035-95-1

CAS 857035-95-1 · EC 469-500-8

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0 % The direction for use “wear suitable gloves” must be included in label or leaflet text. · To be printed on the label: The mixing ratio. “Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.” Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 279 · version 2026-1 · source checked 2026-08-30

2,3-Dibromopropan-1-ol

CAS 96-13-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 647 · version 2026-1 · source checked 2026-08-30

2,3-Dichloro-2-methylbutane

CAS 507-45-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 36 · version 2026-1 · source checked 2026-08-30

2,3-Dichloropropene

CAS 78-88-6

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1102 · version 2026-1 · source checked 2026-08-30

2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt Dihydroxyindoline CAS No 29539-03-5 Dihydroxyindoline HBr CAS No 138937-28-7

CAS 29539-03-5; 138937-28-7

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair dye substance in non- oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · 2.0% · The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use “wear suitable gloves” must be included in label or leaflet text. · Can cause allergic reaction Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 204 · version 2026-1 · source checked 2026-08-30

2,3-Dihydro-2,2-dimethyl-6-[(4-(phenylazo)-1-naphthelenyl)azo]-

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1265 · version 2026-1 · source checked 2026-08-30

2,3-Dinitrotoluene

CAS 602-01-7

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 690 · version 2026-1 · source checked 2026-08-30

2,3-Epoxypropan-1-ol

CAS 556-52-5

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 660 · version 2026-1 · source checked 2026-08-30

2,3-Epoxypropyl methacrylate; glycidyl methacrylate

CAS 106-91-2

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1593 · version 2026-1 · source checked 2026-08-30

2,3-Epoxypropyl o-tolyl ether

CAS 2210-79-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1042 · version 2026-1 · source checked 2026-08-30

2,3-Epoxypropyltrimethylammonium chloride; glycidyl

CAS 3033-77-0 · EC 221-221-0

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1473 · version 2026-1 · source checked 2026-08-30

2,3-Naphthalenediol, when used as a substance in hair dye

CAS 92-44-4 · EC 202-156-7

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1213 · version 2026-1 · source checked 2026-08-30

2,4 Pyrimidinediamine, 3-oxide Diaminopyrimidine oxide CAS No 74638-76-9

CAS 74638-76-9

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair care products · 1.5 %

Source:ASEAN Annex III, reference 93 · version 2026-1 · source checked 2026-08-30

2,4,5,6-Tetraaminopyrimidine sulphate Tetraaminopyrimidine Sulfate CAS No 5392-28-9

CAS 5392-28-9 · EC 226-393-0

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · (b) 3.4%(calculated as sulphate) · (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 3.4% (calculated as sulphate) (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text. · (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary “black henna” tattoo in the past (a) and (b) Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 255 · version 2026-1 · source checked 2026-08-30

2,4,5-Trimethylaniline [1]; 2,4,5-trimethylaniline hydrochloride

CAS 137-17-7

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1158 · version 2026-1 · source checked 2026-08-30

2,4,6-Trianilino-(p-carbo-2’-ethylhexyl-1’-oxy)-1,3,5- triazine (Octyl triazone) CAS No. 88122-99-0

CAS 88122-99-0 · EC 402-070-1

ASEAN Annex VII lists this record among UV filters allowed for cosmetic use. Member-state transition rules and deviations still require local verification.

Conditions: 5%

Source:ASEAN Annex VII, reference 15 · version 2026-1 · source checked 2026-08-30

2,4,6-Trichlorophenol

CAS 88-06-2

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1111 · version 2026-1 · source checked 2026-08-30

2,4,6-tri-tert-butylphenol

CAS 32-26-3

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1701 · version 2026-1 · source checked 2026-08-30

2,4-Diamino-5-methylphenetol and its HCl salt, when used as a

CAS 113715-25-6

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1227 · version 2026-1 · source checked 2026-08-30

2,4-Diamino-5-methylphenoxyethanol and its salts, when used

CAS 141614-05-3

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1314 · version 2026-1 · source checked 2026-08-30

2,4-Diaminodiphenylamine, when used as a substance in hair

CAS 136-17-4

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1214 · version 2026-1 · source checked 2026-08-30

2,4-Diaminophenoxyethanol, its hydrochloride and its sulphate 2,4-Diaminophenoxyethanol HCl 2,4-Diaminophenoxyethanol sulphate CAS No 70643-19-5/ 66422-95-5/ 70643-20-8

CAS 70643-19-5; 66422-95-5; 70643-20-8 · EC 266-357-1

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0 % (as hydrochloride) The direction for use “wear suitable gloves” must be included in label or leaflet text. · The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 244 · version 2026-1 · source checked 2026-08-30

2,4-Diaminophenylethanol and its salts

CAS 14572-93-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 407 · version 2026-1 · source checked 2026-08-30

2,4-Dichlorobenzyl alcohol CAS No. 1777-82-8

CAS 1777-82-8 · EC 217-210-5

ASEAN Annex VI lists this record among preservatives allowed for cosmetic use. Member-state transition rules and deviations still require local verification.

Conditions: 0.15%

Source:ASEAN Annex VI, reference 22 · version 2026-1 · source checked 2026-08-30

2,4-Dihydroxy-3-methylbenzaldehyde, when used as a fragrance

CAS 6248-20-0

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 428 · version 2026-1 · source checked 2026-08-30

2,5-Dinitrotoluene

CAS 619-15-8

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 695 · version 2026-1 · source checked 2026-08-30