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InventoryRef 8456615/10/2010

ETHOXYETHANOL

ETHOXYETHANOL is linked to 1 EU annex record on this page. Inventory note: II/666.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Prohibited entry found
Open this evidence		1English and EU languages
Great BritainEvidence linked
Prohibited
Open this evidence		1English
CanadaEvidence linked
Prohibited
Open this evidence		1English and French
New ZealandEvidence linked
Prohibited
Open this evidence		1English
ASEANEvidence linked
Prohibited
Open this evidence		1English and national languages
ChinaEvidence linked
Prohibited
Open this evidence		1Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaEvidence linked
Prohibited
Open this evidence		1Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilEvidence linked
Prohibited
Open this evidence		1Portuguese with INCI crosswalks
IndiaEvidence linked
Prohibited
Open this evidence		1English and Hindi
Saudi ArabiaEvidence linked
Prohibited
Open this evidence		1Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 110-80-5
CAS 110-80-5PubChem CID 8076

Glycol monoethyl ether

2-ethoxyethanol is a hydroxyether that is the ethyl ether derivative of ethylene glycol. It has a role as a protic solvent and a teratogenic agent. It is a primary alcohol and a glycol ether. It is functionally related to an ethylene glycol. — ChEBI

IUPAC name
2-ethoxyethanol
Molecular formula
C4H10O2
Molecular weight
90.12 g/mol
Exact mass
90.068079557 Da
XLogP3
-0.3
Topological polar surface area
29.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

ETHYLENE GLYCOL MONOETHYL ETHEREthyl cellosolveEmkanolHydroxy etherEthanol, 2-ethoxy-2-Ethoxyethan-1-OlDowanol EEEthylene glycol ethyl ether
16 more reported names
Jeffersol EECellosolve solventPlastiazan 602-Ethoxyethyl alcoholSolvidEthylethylene glycolEktasolve EEEGEEbeta-EthoxyethanolSolvuloseBikanol E 1Etoksyetylowy alkoholDowanol 8CelosolvEthyl ethylene glycolGlycol ether EE
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8076

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • ERG2024, Guide 127 (Ethylene glycol monoethyl ether): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P316, P318, P321, P330, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]; H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (27.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H331 (74.1%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H332 (25.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H360 (88.4%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H360FD (16.5%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P316, P317, P318, P321, P330, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1236 reports by companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P317, P318, P319, P321, P337+P317, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H303: May be harmful if swallowed [Warning Acute toxicity, oral]; H313: May be harmful in contact with skin [Warning Acute toxicity, dermal]; H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P317, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P317, P318, P319, P321, P332+P317, P337+P317, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Conclusion: On the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that Ethoxyethanol and Ethoxyethanol Acetate are unsafe for use in cosmetic products. Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): The ingredient is unsafe for use in cosmetics Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: Ethylene Glycol Monoethyl ether (EGEE) is a colorless liquid with mild, agreeable odor. It is used as a solvent for nitrocellulose, lacquers and dopes; in varnish removers, cleansing solutions, dye baths; finishing leather with water pigments and dye solutions; increasing stability of emulsions. HUMAN EXPOSURE AND TOXICITY: Short-term exposure: The substance is mildly irritating to the eyes and respiratory tract, may cause effects on the central nervous system, blood, bone marrow, kidneys and liver. Exposure at high levels could cause unconsciousness. Long-term or repeated exposure: The liquid defats the skin, may have effects on the blood and bone marrow. The major long-term effects of exposure for humans are developmental, testicular, and hematological toxicity. A cross-sectional evaluation of semen quality was carried out in workers exposed to EGEE. A control group of workers from the same plant was included. Workers exposed to EGEE had significantly lower average sperm counts than controls, although both groups had lower sperm counts than those found in other occupational groups. In other study, hemoglobin, hematocrit, red cell indices, total and differe Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF value of 3 was calculated for ethylene glycol monoethyl ether(SRC), using a log Kow of -0.32(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2(SRC), determined from a log Kow of -0.32(2) and a regression-derived equation(3), indicates that ethylene glycol monoethyl ether is expected to have very high mobility in soil(SRC). Volatilization of ethylene glycol monoethyl ether from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 4.7X10-7 atm-cu m/mole(4). Ethylene glycol monoethyl ether is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 5.31 mm Hg at 25 °C(5). Utilizing the Japanese MITI test, 76% of the Theoretical BOD was reached in 2 weeks(6) indicating that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2(SRC), determined from a log Kow of -0.32(2) and a regression-derived equation(3), indicates that ethylene glycol monoethyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon a Henry's Law constant of 4.7X10-7 atm-cu m/mole(5). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 74 and 540 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 76% of the Theoretical BOD was reached in 2 weeks(7) indicating that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene glycol monoethyl ether, which has a vapor pressure of 5.31 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethylene glycol monoethyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 22 hrs(SRC), calculated from its rate constant of 1.54X10-11 cu cm/molecule-sec at 25 °C(3). Ethylene glycol monoethyl ether does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Solvent; Not Known or Reasonably Ascertainable; Intermediate; Solids separation (precipitating) agent, not otherwise specified Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Laboratory chemicals; Intermediate; Solids separation (precipitating) agent, not otherwise specified; Not Known or Reasonably Ascertainable; Solvent Source: EPA Chemical Data Reporting (CDR)
  • Cosmetic Ingredient Review Link: CIR ingredient: Ethoxyethanol Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used as an industrial solvent and anti-icing additive to aviation fuels; [ACGIH] Used as a solvent for coatings, inks, adhesives, textile dyes, lacquers, and epoxy resins; [HSDB] Not produced commercially in the EU; [Glycol Ethers Online] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Semiconductor Manufacturing [Category: Industry]; Painting (Solvents) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Solvent for nitrocellulose, lacquers and dopes; in varnish removers, cleansing solutions, dye baths; finishing leather with water pigments and dye solutions; increasing stability of emulsions. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: ... Natural and synthetic resins; mutual solvent for formulation of soluble oils; lacquers and lacquer thinners, dyeing and printing textiles, varnish removers, ... anti-icing additive for aviation fuels. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Chemical intermediate for 2-ethoxyethyl acetate, a solvent Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Solvent for epoxy and other coatings Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for ETHYLENE GLYCOL MONOETHYL ETHER (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 2-Ethoxyethanol, also known by the trademark Cellosolve or ethyl cellosolve, is a solvent used widely in commercial and industrial applications. This is an ideal property as a multi-purpose cleaner and therefore 2-ethoxyethanol is used in products such as varnish removers and degreasing solutions. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ETHOXYETHANOL

INCI name

ETHOXYETHANOL

Record provenance

Inventory reference
84566
Imported identity
ETHOXYETHANOL
Source update
15/10/2010
European Commission CosIng source notes

Key data

CAS
110-80-5
EC
203-804-1
Restriction
II/666
Function
SOLVENT
Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).
VISCOSITY CONTROLLING
Increasing or decreasing the viscosity (thickness) of cosmetics.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#10008 · ETHOXYETHANOL

Ingredients with overlapping formulation functions

ERYTHRITYL TRIETHYLHEXANOATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT
ESCHERICHIA COLI EXTRACT FERMENT FILTRATEBUFFERING; SOLVENT
ETHOXYDIGLYCOLHUMECTANT, PERFUMING, SOLVENT
ETHOXYDIGLYCOL ACETATESOLVENT
ETHOXYETHANOL ACETATESOLVENT
ETHYL ACETATEPERFUMING, SOLVENT
ETHYL AZELAIC ACID/PROPANEDIOL COPOLYMERPLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT, VISCOSITY CONTROLLING
ETHYL ETHERSOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How ETHOXYETHANOL appears in the CosIng inventory

The CosIng inventory lists ETHOXYETHANOL as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ETHOXYETHANOL is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ETHOXYETHANOL appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for ETHOXYETHANOL reads: "II/666". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, ETHOXYETHANOL carries the following function designation(s):

CAS 110-80-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for ETHOXYETHANOL

This page combines the CosIng inventory entry for ETHOXYETHANOL with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research ETHOXYETHANOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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