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InventoryRef 3169215/10/2010

BUTANE

Butane, less than 0.1% w/w butadiene

BUTANE is linked to 1 EU annex record on this page.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Prohibited entry found
Open this evidence		1English and EU languages
Great BritainEvidence linked
Prohibited
Open this evidence		1English
CanadaEvidence linked
Restricted
Open this evidence		1English and French
New ZealandEvidence linked
Prohibited
Open this evidence		1English
ASEANEvidence linked
Prohibited
Open this evidence		1English and national languages
ChinaEvidence linked
Prohibited
Open this evidence		1Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilEvidence linked
Prohibited
Open this evidence		1Portuguese with INCI crosswalks
IndiaEvidence linked
Prohibited
Open this evidence		1English and Hindi
Saudi ArabiaEvidence linked
Prohibited
Open this evidence		1Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 106-97-8
CAS 106-97-8PubChem CID 7843

Butane

Butane is a straight chain alkane composed of 4 carbon atoms. It has a role as a food propellant and a refrigerant. It is a gas molecular entity and an alkane. — ChEBI

IUPAC name
butane
Molecular formula
C4H10
Molecular weight
58.12 g/mol
Exact mass
58.078250319 Da
XLogP3
2.9
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

n-ButaneDiethylMethylethylmethaneButanenButaniButyl hydrideHC 600A 21 (lowing agent)
16 more reported names
R 600n-Butan6LV4FOR43RE943an-C4H10INS NO.943INS-943E-943R-600CHEBI:37808E 943aE-943anormal-ButaneRefChem:6622203-448-7butan
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:37808

butane

A straight chain alkane composed of 4 carbon atoms.

Formula
C4H10
Average mass
58.124 g/mol
Monoisotopic mass
58.07825 Da
Formal charge
0
  • alkane — is a (CHEBI:18310)
  • gas molecular entity — is a (CHEBI:138675)
  • refrigerant — has role (CHEBI:78433)
  • food propellant — has role (CHEBI:78017)
  • antihypertensive agent — has role (CHEBI:35674)
  • refrigerant — has role (CHEBI:78433)
  • food propellant — has role (CHEBI:78017)
  • antihypertensive agent — has role (CHEBI:35674)
  • alkane — is a (CHEBI:18310)
  • gas molecular entity — is a (CHEBI:138675)
Additional curated names
butaneE-943E 943aE-943aE943an-Butann-butanen-C4H10HC 600Hc 600 (hydrocarbon)INS-943INS NO.943N-BUTANER 600R-600R 600 (alkane)
Cross-references from this source
  • CAS: 106-97-8 — NIST Chemistry WebBook
  • CAS: 106-97-8 — ChemIDplus
  • REGISTRY_NUMBER: 1148 — Gmelin
  • REGISTRY_NUMBER: 969129 — Reaxys
  • REGISTRY_NUMBER: 969129 — Beilstein
  • MANUAL_X_REF: Butane — Wikipedia
  • MANUAL_X_REF: NBU — PDBeChem

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2020-11-13. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7843

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.; SKIN: CAUTION: Exposure of skin to compressed gases may result in freezing of the skin. Treatment for frostbite may be necessary. Remove the victim from the source of contamination. IMMEDIATELY wash affected areas gently with COLD water (and soap, if necessary) while removing and isolating all contaminated clothing. Dry carefully with clean, soft towels. If symptoms such as inflammation or irritation develop, IMMEDIATELY call a physician or go to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper resp Source: CAMEO Chemicals
  • ERG2024, Guide 115 (Butane): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Frostbite - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.; Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.; Breathing: Respiratory support Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Health Effects: Butane targets the central nervous system and cardiovascular system. Inhalation of butane can cause frostbite which can result in death from asphyxiation and ventricular fibrillation. (L1283, L1284) Source: Toxin and Toxin Target Database (T3DB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: n-Butane is a colorless, flammable gas at room temperature. It occurs as a component in natural gas from which it is refined. n-Butane is used as fuel, refrigerant and aerosol propellant. The acute toxicity of n-butane has been studied after inhalation exposure in experimental animals. LC50 (4h) was 658 mg/l in rats and LC50 (2h) was 680 mg/l in mice. In dogs, lethal concentrations ranged from 474 to 592 mg/l. A concentration of 308 mg/l caused light anesthesia in mice within 25 minutes, and an exposure to 521 mg/l had similar effect within one minute. n-Butane ... sensitiz/ed/ the myocardium to epinephrine-induced cardiac arrhythmias in dogs after inhalation. No reports on acute toxicity of n-butane in experimental animals by other administration routes were located in the available literature. In a 21-day inhalation toxicity study of a mixture of n-butane, isobutane, n-penta and isopentane, containing 25% of each, the absence of toxicity was evident up to 11.8 mg/l which was the highest concentration tested. The study was performed in Sprague-Dawley rats which were exposed 6 hours per day over three weeks for a total of 15 exposures. No long-term studies using pure n-butane were Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Butane is a simple asphyxiant and causes toxicity by displacing oxygen. It also affects the central nervous system by enhancing glycine receptors and inhibiting N-methyl-d-aspartate (NMDA) receptors. (L1284, A352) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 33 was calculated for n-butane(SRC), using a log Kow of 2.89(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a log Kow of 2.89(2) and a regression-derived equation(3), indicates that n-butane is expected to have high mobility in soil(SRC). Volatilization of n-butane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.95 atm-cu m/mole(SRC), derived from its vapor pressure, 1820 mm Hg(4) and water solubility, 61.2 mg/L(5). The potential for volatilization of n-butane from dry soil surfaces may exist(SRC) based upon its vapor pressure(4). While volatilization from soil surfaces is expected to be the predominant fate process of n-butane released to soil, this compound is also susceptible to biodegradation(SRC). A biodegradation rate of 1.8 mg C/day/kg dry soil(6) suggests that biodegradation may be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a log Kow of 2.89(2) and a regression-derived equation(3), indicates that n-butane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon an estimated Henry's Law constant of 0.95 atm-cu m/mole(SRC), derived from its vapor pressure, 1820 mm Hg(5) and water solubility, 61.2 mg/L(6). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 50 minutes and 3 days, respectively(SRC). According to a classification scheme(7), an estimated BCF of 40(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Photolysis(8) or hydrolysis(4) of n-butane in aquatic systems are not expected to be important environmental fate process in water(SRC). While volatilization from water surfaces is expected to be the predominant fate process in water, this compound is also susceptible to biodegradation(SRC). Complete biodegradation was reported in 34 days using an activated sludge Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), n-butane, which has a vapor pressure of 1820 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase n-butane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6.3 days(SRC), calculated from its rate constant of 2.54X10-12 cu cm/molecule-sec at 25 deg(3). Experimental data showed that 7.7% of the n-butane fraction in a dark chamber reacted with nitrogen oxide to form the corresponding alkyl nitrate(4,5), suggesting nighttime reactions with radical species and nitrogen oxides may contribute to the atmospheric transformation of n-butane(SRC). Based on data for iso-octane and n-hexane(6), n-butane is not expected to absorb UV light at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Intermediate; Propellants, non-motive (blowing agents); Filler; Not Known or Reasonably Ascertainable; Fuels and fuel additives; Fuel; Fuel agents; Other Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Fuels and fuel additives; Processing aids not otherwise specified; Fuel; Fuel agents; Abrasives; Other; Intermediate; Propellants, non-motive (blowing agents); Not Known or Reasonably Ascertainable; Sealant (barrier) Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BUTANE

INCI name

BUTANE

INN name

butane

Description

Butane, less than 0.1% w/w butadiene

Record provenance

Inventory reference
31692
Imported identity
BUTANE
Source update
15/10/2010
European Commission CosIng source notes

Key data

CAS
106-97-8
EC
203-448-7
Restriction
—
Function
PROPELLANT
Generating pressure in an aerosol pack, expelling contents when the valve is opened. Some liquefied propellants can act as solvents.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#4076 · BUTANE

The markets do not agree about this substance: it is prohibited in some and permitted under conditions in others, across the 9 markets that hold a rule for it.

prohibited
European UnionGreat BritainNew ZealandASEANChinaBrazilIndiaSaudi Arabia
restricted
Canada

See every substance the markets disagree about

Ingredients with overlapping formulation functions

CARBON DIOXIDEPROPELLANT
DIMETHYL CARBONATEFRAGRANCE, PROPELLANT, SOLVENT
DIMETHYL ETHERPROPELLANT, SOLVENT, VISCOSITY CONTROLLING
ETHANEPROPELLANT
HYDROCHLOROFLUOROCARBON 142BDEODORANT, PROPELLANT
HYDROCHLOROFLUOROCARBON 22PROPELLANT
HYDROFLUOROCARBON 134APROPELLANT
HYDROFLUOROCARBON 152APROPELLANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How BUTANE appears in the CosIng inventory

The CosIng inventory lists BUTANE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BUTANE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BUTANE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

According to the EU CosIng inventory, BUTANE carries the following function designation(s):

CAS 106-97-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
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Source note for BUTANE

This page combines the CosIng inventory entry for BUTANE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research BUTANE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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