What does the restriction note for HYDROXYETHYL-2-NITRO-P-TOLUIDINE mean?

The restriction field for HYDROXYETHYL-2-NITRO-P-TOLUIDINE reads: III/221. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 100418-33-5?

CAS 100418-33-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains HYDROXYETHYL-2-NITRO-P-TOLUIDINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3450817/10/2010

HYDROXYETHYL-2-NITRO-P-TOLUIDINE

1-Methyl-3-nitro-4-(.beta.-hydroxyethyl)aminobenzene

HYDROXYETHYL-2-NITRO-P-TOLUIDINE is linked to 1 EU annex record on this page. Inventory note: III/221.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Restricted Open this evidence	1	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Restricted Open this evidence	1	English
ASEAN	Evidence linked Restricted Open this evidence	1	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Prohibited + Restricted Open this evidence	2	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Evidence linked Restricted Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Restricted Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 100418-33-5

CAS 100418-33-5PubChem CID 10130360

Hydroxyethyl-2-nitro-p-toluidine

IUPAC name: 2-(4-methyl-2-nitroanilino)ethanol

Molecular formula: C9H12N2O3
Molecular weight: 196.20 g/mol
Exact mass: 196.08479225 Da
XLogP3: 1.6
Topological polar surface area: 78.1 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

2-((4-Methyl-2-nitrophenyl)amino)ethanolEthanol, 2-[(4-methyl-2-nitrophenyl)amino]-4-(2-Hydroxyethylamino)-3-nitrotolueneUNII-KL22OLP94KKL22OLP94KEthanol, 2-((4-methyl-2-nitrophenyl)amino)-2-[(4-METHYL-2-NITROPHENYL)AMINO]ETHANOL4-((2-Hydroxyethyl)amino)-3-nitro-1-methylbenzene

16 more reported names

EC 408-090-7RefChem:147176HYDROXYETHYL-2-NITRO-P-TOLUIDINE [INCI]408-090-7620-681-32-(4-Methyl-2-nitrophenylamino)ethanolN-(2-Hydroxyethyl) 4-methyl-2-nitroanilineN-(beta-Hydroxyethyl)-2-nitro-p-toluidine3-Nitro-4-Hydroxyethy Lamino Toluene3-Nitro-4-hydroxyethylaminotoluene2-(4-methyl-2-nitro-anilino)ethanolSCZQUWZLEIYDBD-UHFFFAOYSA-N3-Nitro-4-hydroxyethylaminotolueneanolAC-81842-(4-Methyl-2-nitroanilino)ethan-1-olAS-13568

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID20143261

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match10130360

Attributed physical-property, hazard, environmental and use annotations.

Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P261, P264, P270, P272, P273, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P261, P264, P270, P272, P273, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 61 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Precautionary Statement Codes: P261, P264, P270, P272, P273, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
EMBL-EBI ChEBI	No exact record	2026-08-31
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HYDROXYETHYL-2-NITRO-P-TOLUIDINE

INCI name

HYDROXYETHYL-2-NITRO-P-TOLUIDINE

Description

1-Methyl-3-nitro-4-(.beta.-hydroxyethyl)aminobenzene

Record provenance

Inventory reference: 34508
Imported identity: HYDROXYETHYL-2-NITRO-P-TOLUIDINE
Source update: 17/10/2010

European Commission CosIng source notes

Annex records for HYDROXYETHYL-2-NITRO-P-TOLUIDINE

Annex III Restriction reference

Entry 221

Hydroxyethyl-2-Nitro-p-Toluidine

CAS: 100418-33-5

EC: 408-090-7

Key data

CAS

100418-33-5

408-090-7

Restriction

III/221

Function

HAIR DYEING: Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#13274 · HYDROXYETHYL-2-NITRO-P-TOLUIDINE

The markets do not agree about this substance: it is prohibited in some and permitted under conditions in others, across the 7 markets that hold a rule for it.

prohibited: South Korea
restricted: European Union Great Britain New Zealand ASEAN India Saudi Arabia

South Korea holds more than one rule for this substance, so its position there depends on the use.

See every substance the markets disagree about

Ingredients with overlapping formulation functions

HYDROXYANTHRAQUINONEAMINOPROPYL METHYL MORPHOLINIUM METHOSULFATEHAIR DYEING

HYDROXYBENZOMORPHOLINEHAIR DYEING

HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCLHAIR DYEING

HYDROXYETHYL-2,6-DINITRO-P-ANISIDINEHAIR DYEING

HYDROXYETHYL-3,4-METHYLENEDIOXYANILINE HCLHAIR DYEING

HYDROXYETHYL-P-PHENYLENEDIAMINE SULFATEHAIR DYEING

HYDROXYETHYLAMINOMETHYL-P-AMINOPHENOLHAIR DYEING

HYDROXYETHYLAMINOMETHYL-P-AMINOPHENOL HCLHAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How HYDROXYETHYL-2-NITRO-P-TOLUIDINE appears in the CosIng inventory

The CosIng inventory lists HYDROXYETHYL-2-NITRO-P-TOLUIDINE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HYDROXYETHYL-2-NITRO-P-TOLUIDINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HYDROXYETHYL-2-NITRO-P-TOLUIDINE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for HYDROXYETHYL-2-NITRO-P-TOLUIDINE reads: "III/221". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, HYDROXYETHYL-2-NITRO-P-TOLUIDINE carries the following function designation(s):

HAIR DYEING

CAS 100418-33-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for HYDROXYETHYL-2-NITRO-P-TOLUIDINE

This page combines the CosIng inventory entry for HYDROXYETHYL-2-NITRO-P-TOLUIDINE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research HYDROXYETHYL-2-NITRO-P-TOLUIDINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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