InventoryRef 5419315/10/2010
2-AMINO-5-NITROPHENOL
2-Amino-5-nitrophenol
2-AMINO-5-NITROPHENOL is linked to 1 EU annex record on this page. Inventory note: II/384.
Regulatory evidence by market
This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.
Swipe or scroll horizontally to see every column.
| Market | Evidence status | Records | Source language |
|---|---|---|---|
| European Union | Evidence linked Prohibited entry found Open this evidence | 1 | English and EU languages |
| Great Britain | Evidence linked Prohibited Open this evidence | 1 | English |
| Canada | Evidence linked Prohibited Open this evidence | 1 | English and French |
| New Zealand | Evidence linked Prohibited Open this evidence | 1 | English |
| ASEAN | Evidence linked Prohibited Open this evidence | 1 | English and national languages |
| China | Evidence linked Prohibited Open this evidence | 1 | Chinese with selected English material |
| Japan | Source mapped Official source mapped; ingredient rule not imported | 0 | Japanese; official English translation available |
| South Korea | Evidence linked Prohibited Open this evidence | 1 | Korean with some English names |
| United States | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Australia | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Brazil | Evidence linked Prohibited Open this evidence | 1 | Portuguese with INCI crosswalks |
| India | Evidence linked Prohibited Open this evidence | 1 | English and Hindi |
| Saudi Arabia | Evidence linked Prohibited Open this evidence | 1 | Arabic and English |
Chemical identity and properties
CAS 121-88-0PubChem CID 4984721
2-Amino-5-Nitrophenol
2-Amino-5-nitrophenol is a member of 3-nitrophenols. — ChEBI
- IUPAC name
- 2-amino-5-nitrophenol
- Molecular formula
- C6H6N2O3
- Molecular weight
- 154.12 g/mol
- Exact mass
- 154.03784206 Da
- XLogP3
- 1.5
- Topological polar surface area
- 92.1 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
5-Nitro-2-aminophenol2-Hydroxy-4-nitroanilineUrsol Yellow Brown A3-Nitro-6-aminophenolPhenol, 2-amino-5-nitro-Rodol YBA3-Hydroxy-4-aminonitrobenzeneC.I. 76535
16 more reported names
NCI C55970CI 76535NSC-7087DTXCID20630149H05U82RefChem:464654204-503-82-Amino-5-nitro-phenolNSC 70875-nitro-2-amino-1-hydroxybenzeneN.C.I. C55970CCRIS 754HSDB 4168EINECS 204-503-8BRN 0972974AI3-52548
External database identifiers
- ChEBI:CHEBI:82384
- ChEMBL:CHEMBL164989
- EPA DTXSID:DTXSID1020063
- PubMed:22952646
- PubMed:22091177
- PubMed:21110342
- PubMed:20086194
- PubMed:19581339
- PubMed:17950496
- PubMed:17598023
- PubMed:12498276
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match4984721
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: Olive-brown, brown to orange crystalline solid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Orange needles when recrystallized from water Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 388 to 396 °F (decomposes) (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 205.8 °C Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: 2-amino-5-nitrophenol appears as brown amorphous granules or powder. Melting point 198-202 °C. Source: CAMEO Chemicals
- Physical Description: Olive-brown, brown, or orange solid; [HSDB] Green crystalline solid; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: less than 1 mg/mL at 68 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Slightly soluble in water Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in ethanol, acetone, and benzene Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in deuterated DSMO Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 0.0000352 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- IARC Carcinogenic Agent: 2-Amino-5-nitrophenol Source: International Agency for Research on Cancer (IARC)
- IARC Carcinogenic Classes: Group 3: Not classifiable as to its carcinogenicity to humans Source: International Agency for Research on Cancer (IARC)
- IARC Monographs: Volume 57: (1993) Occupational Exposures of Hairdressers and Barbers and Personal Use of Hair Colourants; Some Hair Dyes, Cosmetic Colourants, Industrial Dyestuffs and Aromatic Amines Source: International Agency for Research on Cancer (IARC)
- Publication Year: 1993 Source: International Agency for Research on Cancer (IARC)
- Evaluation Year: 1992 Source: International Agency for Research on Cancer (IARC)
- Substance: 2-Amino-5-Nitrophenol Source: NTP Technical Reports
- NTP Technical Report: TR-334: Toxicology and Carcinogenesis Studies of 2-Amino-5-Nitrophenol (CASRN 121-88-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1988 ) Source: NTP Technical Reports
- Peer Review Date: 03/04/87 Source: NTP Technical Reports
- Conclusion for Male Rat: Some Evidence Source: NTP Technical Reports
- Conclusion for Female Rat: No Evidence Source: NTP Technical Reports
- Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
- Conclusion for Female Mice: No Evidence Source: NTP Technical Reports
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (95%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (> 99.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (94.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H351 (92.7%): Suspected of causing cancer [Warning Carcinogenicity]; H411 (97.5%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2175 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for 2-amino-5-nitrophenol(SRC), using an estimated log Kow of 0.99(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 85(SRC), determined from a structure estimation method(2), indicates that 2-amino-5-nitrophenol is expected to have high mobility in soil(SRC). Volatilization of 2-amino-5-nitrophenol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 7.8X10-13 atm-cu m/mole(SRC), using a fragment constant estimation method(3). 2-Amino-5-nitrophenol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.5X10-5 mm Hg(SRC), determined from a fragment constant method(4). Biodegradation data were not available(SRC, 2007). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 85(SRC), determined from a structure estimation method(2), indicates that 2-amino-5-nitrophenol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 7.8X10-13 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of 0.99(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions(3). Biodegradation data were not available(SRC, 2007). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-amino-5-nitrophenol, which has an estimated vapor pressure of 3.5X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 2-amino-5-nitrophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 41 hours(SRC), calculated from its rate constant of 9.4X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase 2-amino-5-nitrophenol may be removed from the air by wet or dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Cosmetic Ingredient Review Link: CIR ingredient: 2-Amino-5-Nitrophenol Source: Cosmetic Ingredient Review (CIR)
- Sources/Uses: Used in hair dyes and to make azo dyes; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Dressing Hair [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: 2-Amino-5-nitrophenol is used as an intermediate in the manufacture of several azo dyes, including CI Solvent Red 8, which is used for coloring synthetic resins, lacquers, inks and wood stains. It is also used as a dye in semi-permanent hair coloring products to produce red and gold-blond shades. It is used to a limited extent in permanent hair coloring products. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for 2-AMINO-5-NITROPHENOL
INCI name
2-AMINO-5-NITROPHENOL
Description
2-Amino-5-nitrophenol
Record provenance
- Inventory reference
- 54193
- Imported identity
- 2-AMINO-5-NITROPHENOL
- Source update
- 15/10/2010
Annex records for 2-AMINO-5-NITROPHENOL
Key data
CAS
EC
—
Restriction
II/384
Function
- HAIR DYEING
- Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How 2-AMINO-5-NITROPHENOL appears in the CosIng inventory
The CosIng inventory lists 2-AMINO-5-NITROPHENOL as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.
2-AMINO-5-NITROPHENOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
2-AMINO-5-NITROPHENOL appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.
The restriction field for 2-AMINO-5-NITROPHENOL reads: "II/384". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.
According to the EU CosIng inventory, 2-AMINO-5-NITROPHENOL carries the following function designation(s):
CAS 121-88-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for 2-AMINO-5-NITROPHENOL
This page combines the CosIng inventory entry for 2-AMINO-5-NITROPHENOL with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.
Use this inventory page to research 2-AMINO-5-NITROPHENOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
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