What does the restriction note for METHYLENE GLYCOL mean?

The restriction field for METHYLENE GLYCOL reads: II/1579. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 463-57-0?

CAS 463-57-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains METHYLENE GLYCOL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8667830/07/2020

METHYLENE GLYCOL

Methanediol; formaldehyde hydrate

METHYLENE GLYCOL is linked to 1 EU annex record on this page. Inventory note: II/1579.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Evidence linked Restricted Open this evidence	1	English and French
New Zealand	Evidence linked Prohibited Open this evidence	1	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Prohibited Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Evidence linked Prohibited Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 463-57-0

CAS 463-57-0PubChem CID 79015

Methanediol

Methanediol is the simplest member of the class of methanediols that is methane in which two of the hydrogens have been substituted by hydroxy groups. It is a member of methanediols, an aldehyde hydrate and a one-carbon compound. — ChEBI

IUPAC name: methanediol

Molecular formula: CH4O2
Molecular weight: 48.041 g/mol
Exact mass: 48.021129366 Da
XLogP3: -1.0
Topological polar surface area: 40.5 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

Methylene glycoldihydroxymethaneCHEBI:483976Z20YM9257RefChem:156911207-339-5formaldehyde hydrateMethandiol

8 more reported names

Methanediol-UNII-6Z20YM9257EINECS 207-339-5Paraformaldehyde, powderSCHEMBL4597UNII-T0H3L6C7I5T0H3L6C7I5Aldacide; Flo-Mor; Granuform; Paraform; TransFix

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:48397
EPA DTXSID:DTXSID50196801
PubMed:23107743
PubMed:23083173
PubMed:23040986
PubMed:23040976
PubMed:23019898
PubMed:23013883
PubMed:22997100
PubMed:22989911
PubMed:22970576
PubMed:22970569
PubMed:22970566
PubMed:22967028

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for METHYLENE GLYCOL

INCI name

METHYLENE GLYCOL

Description

Methanediol; formaldehyde hydrate

Record provenance

Inventory reference: 86678
Imported identity: METHYLENE GLYCOL
Source update: 30/07/2020

European Commission CosIng source notes

Annex records for METHYLENE GLYCOL

Annex II Restriction reference

Entry 1579

Methanediol; methylene glycol

CAS: 463-57-0

EC: 207-339-5

Key data

CAS

463-57-0

207-339-5

Restriction

II/1579

Function

NAIL CONDITIONING: Improving and/or enhancing the cosmetic characteristics of the nail (moisturizing, increasing sheen, reducing brittleness and flaking, etc.).
NAIL SCULPTING: Forming a hard structure that resembles the nail plate.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#16620 · METHYLENE GLYCOL

The markets do not agree about this substance: it is prohibited in some and permitted under conditions in others, across the 8 markets that hold a rule for it.

prohibited: European Union Great Britain New Zealand ASEAN South Korea India Saudi Arabia
restricted: Canada

See every substance the markets disagree about

Ingredients with overlapping formulation functions

BIS-(TMP DIALLYL ETHER) IPDINAIL SCULPTING

CYCLOHEXYLMETHACRYLATENAIL SCULPTING

DI-HEMA TRIMETHYLHEXYL DICARBAMATENAIL SCULPTING

HEMANAIL SCULPTING

POLYURETHANE-83NAIL SCULPTING

SESQUI(ACRYLOYLOXYETHYL) PHOSPHATEADHESIVE; NAIL SCULPTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How METHYLENE GLYCOL appears in the CosIng inventory

The CosIng inventory lists METHYLENE GLYCOL as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

METHYLENE GLYCOL is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

METHYLENE GLYCOL appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for METHYLENE GLYCOL reads: "II/1579". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, METHYLENE GLYCOL carries the following function designation(s):

CAS 463-57-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for METHYLENE GLYCOL

This page combines the CosIng inventory entry for METHYLENE GLYCOL with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research METHYLENE GLYCOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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