CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Permitted list with conditionsBinding ruleASEANOriginal is EnglishOfficial-source import checked

2,2’-Methylene-bis(6-(2H-benzotriazol-2-yl)-4- (tetramethyl-butyl)-1,1,3,3-phenol);2,2’- Methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3- tetramethylbutyl)phenol) (Methylene Bis- Benzotriazolyl Tetramethylbutylphenol (nano)/MBBT (nano)) CAS No. 103597-45-1

2,2’-Methylene-bis(6-(2H-benzotriazol-2-yl)-4- (tetramethyl-butyl)-1,1,3,3-phenol);2,2’- Methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3- tetramethylbutyl)phenol) (Methylene Bis- Benzotriazolyl Tetramethylbutylphenol (nano)/MBBT (nano)) CAS No. 103597-45

ASEAN Annex VII lists this record among UV filters allowed for cosmetic use. Member-state transition rules and deviations still require local verification.

All ASEAN recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Permitted list with conditions
Legal role
Binding rule
Regulatory summary
ASEAN Annex VII lists this record among UV filters allowed for cosmetic use. Member-state transition rules and deviations still require local verification.
Conditions and restrictions
10%(5) · Not to be used in applications that may lead to exposure of the end user's lungs by inhalation. Only nanomaterials having the following characteristics are allowed: - Purity ≥ 98.5 %, with 2,2′- methylene-bis-(6(2H- benzotriazol-2-yl)-4- (isooctyl)phenol) isomer fraction not exceeding 1.5 %; - Solubility < 5 ng/L in water at 25 °C; - Partition coefficient (Log Pow): 12.7 at 25 °C; - Uncoated; - Median particle size D50 (50% of number below this diameter): ≥ 120 nm of mass distribution and/or ≥ 60 nm of number size distribution.

Substance identity

Official source name
2,2’-Methylene-bis(6-(2H-benzotriazol-2-yl)-4- (tetramethyl-butyl)-1,1,3,3-phenol);2,2’- Methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3- tetramethylbutyl)phenol) (Methylene Bis- Benzotriazolyl Tetramethylbutylphenol (nano)/MBBT (nano)) CAS No. 103597-45-1
CAS
103597-45-1
EC
403-800-1
Identity mapping
cas_number
Linked ingredient
METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL
Search this identity across the siteCAS 103597-45-1EC 403-800-1

Linked CosIng identity data

Names and aliases

METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOLbisoctrizole

CosIng description: 2,2'-Methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)

EU inventory restriction note: VI/23

Recorded cosmetic function: LIGHT STABILIZER, UV FILTER

Function pages:LIGHT STABILIZER, UV FILTER

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

5 market datasets

European Union

Positive-list entry with conditions

2 linked records · 2 with specific conditions

Open supporting record

Great Britain

Permitted list with conditions

2 linked records · 2 with specific conditions

Open supporting record

ASEAN

Current record
Permitted list with conditions

2 linked records · 2 with specific conditions

Open supporting record
PubChem 2D chemical structure for CAS 103597-45-1
CAS 103597-45-1PubChem CID 3571576

Verified chemistry for CAS 103597-45-1

Bisoctrizole

Bisoctrizole is a diarylmethane. — ChEBI

IUPAC name
2-(benzotriazol-2-yl)-6-[[3-(benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol
Molecular formula
C41H50N6O2
Molecular weight
658.9 g/mol
Exact mass
658.39952486 Da
Monoisotopic mass
658.39952486 Da
XLogP3
12.8
Topological polar surface area
102.0 Ų
Molecular complexity
989.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
6
Rotatable bonds
10
Heavy atoms
49
Covalent units
1

Names and synonyms reported to PubChem

FAT 75'634Bisoctrizole [USAN]Bisoctrizol8NT850T0YSNSC-759873BISOCTRIZOLE [MI]FAT-75634BISOCTRIZOLE [INN]
16 more reported names
BISOCTRIZOLE [MART.]BISOCTRIZOLE [USP-RS]BISOCTRIZOLE [WHO-DD]BISOCTRIZOLE [USP MONOGRAPH]2-(2H-1,2,3-benzotriazol-2-yl)-6-{[3-(2H-1,2,3-benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl}-4-(2,4,4-trimethylpentan-2-yl)phenolPhenol, 2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-Phenol, 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-BISOCTRIZOLE (MART.)BISOCTRIZOLE (USP-RS)BISOCTRIZOLE (USP MONOGRAPH)2,2'-METHYLENEBIS(6-(2-BENZOTRIAZOLYL)-4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL2,2'-METHYLENEBIS(6-(2-BENZOTRIAZOLYL)-4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL)PHENOL, 2,2'-METHYLENEBIS(6-(2H-BENZOTRIALZOL-2-YL)-4-(1,1,3,3-TETRAMETHYLBUTYL)-bisoctrizolumPhenol, 2,2'-methylenebis[6-(2H-benzotriazol-2-yl]-4-(1,1,3,3-tetramethylbutyl)-2-(2H-1,2,3-benzotriazol-2-yl)-6-((3-(2H-1,2,3-benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl)methyl)-4-(2,4,4-trimethylpentan-2-yl)phenol
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
16
3D rings
6
3D hydrophobes
4
3D acceptor features
4
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
10.0
Machine-readable structure identifiers
SMILES
CC(C)(C)CC(C)(C)C1=CC(=C(C(=C1)N2N=C3C=CC=CC3=N2)O)CC4=C(C(=CC(=C4)C(C)(C)CC(C)(C)C)N5N=C6C=CC=CC6=N5)O
InChI
InChI=1S/C41H50N6O2/c1-38(2,3)24-40(7,8)28-20-26(36(48)34(22-28)46-42-30-15-11-12-16-31(30)43-46)19-27-21-29(41(9,10)25-39(4,5)6)23-35(37(27)49)47-44-32-17-13-14-18-33(32)45-47/h11-18,20-23,48-49H,19,24-25H2,1-10H3
InChIKey
FQUNFJULCYSSOP-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:135865

bisoctrizole

Formula
C41H50N6O2
Average mass
658.891 g/mol
Monoisotopic mass
658.39952 Da
Formal charge
0
  • diarylmethane — is a (CHEBI:51614)
  • diarylmethane — is a (CHEBI:51614)
Additional curated names
bisoctyltriazoleFAT 75'634FAT-75634MBBTNSC-759873
Cross-references from this source
  • CAS: 103597-45-1 — DrugCentral
  • MANUAL_X_REF: 3031 — DrugCentral

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-02-23. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match3571576

Attributed physical-property, hazard, environmental and use annotations.

  • Solubility: < 5 ng/L at 25 °C Source: DrugBank
  • GHS Hazard Statements: H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 1.7% (14 of 842) of reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H413 (98.3%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 842 reports by companies from 4 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 14 of 842 reports by companies.; There are 3 notifications provided by 828 of 842 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H413 (100%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 107 reports by companies from 1 notifications to the ECHA C&L Inventory.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Uses: Plastics -> Typical concentration range in plastic materials -> 0.2 - 6.0% Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
ASEAN Cosmetic Directive annexes
Source reference
ASEAN Annex VII, reference 23a
Source record ID
VII-23a
Source version
2026-1
Source language
English
Translation status
Original is English
Source updated
2026-06-22
Snapshot checked
2026-08-30 04:44 UTC
Validation method
pdfplumber ruled-table extraction with per-annex reviewed counts
SHA-256
ffad59f6c01a92c82042c54203ee14969425c2a82bd04c2f4012ff82513e69f1

Registered dataset notes

Dataset coverage
Banned, restricted and positive-list substances under the harmonised ASEAN framework
Authority note
Regional directive; member-state transitions and deviations still require local verification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2224
current ASEAN records
247
records marked Permitted list with conditions
2224
records from this source version
1930
market records with CAS identity

Status distribution

Permitted list with conditions: 247Prohibited: 1728Restricted: 249

Condition text is present on 462 of 2224 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

ASEAN market context

Complete regional annex dataset

Coverage version: ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

Annexes II, III, IV, VI and VII covering prohibited, restricted and positive-list substances.

Verification checklist

  1. Search all ACD annexes by name and identifiers.
  2. Apply product type, maximum level and warning conditions.
  3. Confirm the target member state's adoption and transition date.
  4. Complete the local notification and responsible-company requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “2,2’-Methylene-bis(6-(2H-benzotriazol-2-yl)-4- (tetramethyl-butyl)-1,1,3,3-phenol);2,2’- Methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3- tetramethylbutyl)phenol) (Methylene Bis- Benzotriazolyl Tetramethylbutylphenol (nano)/MBBT (nano)) CAS No. 103597-45-1” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search all ACD annexes by name and identifiers.
  3. Apply product type, maximum level and warning conditions.
  4. Confirm the target member state's adoption and transition date.
  5. Complete the local notification and responsible-company requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This identity appears on a market positive list for the list function represented by the source record. Confirm that the intended function and product use fall within the list scope and every stated condition.

Positive-list presence is purpose-specific and is not blanket approval for every cosmetic use. Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

The record cites ASEAN Annex VII, reference 23a, source version 2026-1. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

2,2’-Methylene-bis(6-(2H-benzotriazol-2-yl)-4- (tetramethyl-butyl)-1,1,3,3-phenol);2,2’- Methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3- tetramethylbutyl)phenol) (Methylene Bis- Benzotriazolyl Tetramethylbutylphenol (nano)/MBBT (nano)) CAS No. 103597-45-1. ASEAN Annex VII, reference 23a. ASEAN. Source version 2026-1. CosIng Checker regulatory record: https://cosingchecker.com/regulations/asean/records/4346/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for ASEAN

This identity appears on a market positive list for the list function represented by the source record.

Confirm that the intended function and product use fall within the list scope and every stated condition.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Permitted list with conditions
  • Legal role: Binding rule
  • Source version: 2026-1

What it does not prove

Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source