India cosmetic ingredient regulations

1-Bromo-3,4,5-trifluorobenzene (CAS No. 138526-69-9)

CAS 138526-69-9

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 999 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Butyl-3-(N-crotonoylsulphanilyl)urea (CAS No. 52964-42-8)

CAS 52964-42-8

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 107 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Chloro-2,3-epoxypropane (epichlorohydrin) (CAS No. 106-89-8)

CAS 106-89-8 · EC 203-439-8

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 647 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (CAS No. 93107-30-3)

CAS 93107-30-3

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1396 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Dimethylaminomethyl-1-methylpropyl benzoate (amylocaine) and its salts (CAS No. 644-26-8)

CAS 644-26-8

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 50 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Ethyl-1-methylmorpholinium bromide (CAS No. 65756-41-4)

CAS 65756-41-4

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1064 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Ethyl-1-methylpyrrolidinium bromide (CAS No. 69227-51-6)

CAS 69227-51-6

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1071 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Hydroxy-2,4-diaminobenzene (2,4-Diaminophenol) (CAS No. 95-86-3) and its dihydrochloride salts (2,4-Diaminophenol HCl) (CAS No. 137-09-7) when used as a substance in hair dye products

CAS 95-86-3; 137-09-7 · EC 202-459-4

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1311 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Hydroxy-2-beta- hydroxyethylamino-4,6- dinitrobenzene 2-Hydroxyethyl picramic acid (CAS No. 99610-72-7)

CAS 99610-72-7 · EC 412-520-9

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: a)Hair dye substance in oxidative hair dye products b)Hair dye substance in non- oxidative hair dye products | Maximum authorised concentration: b)2.0 percent | Other limitations/requirements: a)After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5 percent For a) and b): 1)Do not use with nitrosating agents 2)Maximum nitrosamine and content: 50 μg/kg 3)Keep in nitrite-free containers. | Label conditions/warnings: a)To be printed on the label: The mixing ratio. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: 1)you have a rash on your face or sensitive, irritated and damaged scalp 2)you have ever experienced any reaction after colouring your hair and 3)you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.

Source:IS 4707 (Part 2):2025 Annex B, entry 209 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Hydroxy-2-methylnaphth- alene 2-Methyl-1-Naphthol (CAS No. 7469-77-4)

CAS 7469-77-4 · EC 231-265-2

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: Hair dye substance in oxidative hair dye products | Other limitations/requirements: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0 percent (When both 2-Methyl-1- Naphthol and 1-Acetoxy-2- Methyl-naphthalene are present in a hair dye formulation, the maximum concentration on the head of 2-Methyl-1-Naphthol should not exceed 2.0 percent.) | Label conditions/warnings: To be printed on the label: The mixing ratio. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if, a)you have a rash on your face or sensitive, irritated and damaged scalp b)you have ever experienced any reaction after colouring your hair and c)you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.

Source:IS 4707 (Part 2):2025 Annex B, entry 241 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Hydroxy-3-nitro-4- (3- hydroxypropylamino)benz- 15 ene ( ) 4-Hydroxypropy- lamino-3-nitrophenol (CAS 92952-81-3)

CAS 92952-81-3 · EC 406-305-9

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: a)Hair dye substance in oxidative hair dye products b)Hair dye substance in non-oxidative hair dye products | Maximum authorised concentration: (b) 2.6 percent | Other limitations/requirements: a)After mixing under oxidative conditions the maximum concen- tration applied to hair must not exceed 2.6 percent calculated as free base. For (a) and (b): 1)Do not use with nitro- sating systems 2)Maximum nitrosamine and content: 50 μg/kg 3)Keep in nitrite-free containers. | Label conditions/warnings: a)To be printed on the label: The mixing ratio. ‘Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. s may Temporary “black henna” tattoo increase your risk of allergy. Do not colour your hair if: 1)you have a rash on your face or sensitive, irritated and damaged scalp 2)you have ever experienced any reaction after colouring your hair and 3)you have experienced a reaction to a tem porary “black henna” tattoo in the past.

Source:IS 4707 (Part 2):2025 Annex B, entry 200 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Hydroxy-4-(p-toluidino) anthraquinone (solvent violet 13; CI 60725) (CAS No. 81-48-1) when used as a substance in hair dye products

CAS 81-48-1

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1336 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Methoxy-2,4-diaminobenzene (2,4-diaminoanisole - CI 76050) and its salts (CAS No. 615-05-4)

CAS 615-05-4

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 373 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Methoxy-2,5-diaminobenzene (2,5-diaminoanisole) and its salts (CAS No. 5307-02-8)

CAS 5307-02-8

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 374 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Methoxy-3-(ß-aminoethyl)- amino-4-nitrobenzene, Hydro- chloride HC Yellow No 9 (CAS No. 86419-69-4)

CAS 86419-69-4 · EC 415-480-1

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: Hair dye substance in non- oxidative hair dye products | Maximum authorised concentration: 0.5 percent (calculated as hydrochloride) | Other limitations/requirements: a)Do not use with nitrosating agents b)Maximum nitrosamine content: 50 µg/kg; and c)Keep in nitrite-free containers.

Source:IS 4707 (Part 2):2025 Annex B, entry 249 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Methyl-2,4,5-trihydroxybenzene (CAS No. 1124-09-0) and its salts, when used as a substance in hair dye products

CAS 1124-09-0

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1217 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Methyl-2,6-bis-(2-hyd- roxy ethylamino)-benzene 2,6-Dihydroxyethylami- notoluene (CAS No. 149330-25-6)

CAS 149330-25-6 · EC 443-210-1

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: Hair dye substance in oxidative hair dye products | Other limitations/requirements: After mixing under oxidative conditions, the maximum concentration applied to hair must not exceed 1.0 percent. a)Do not use with nitrosating agent b)Maximum nitrosamine content 50 µg/kg; and c)Keep in nitrite free container. | Label conditions/warnings: To be printed on the label: The mixing ratio. ‘Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: a)you have a rash on your face or sensitive, irritated and damaged scalp b)you have ever experienced any reaction after colouring your hair; and c)you have experienced a reaction to a temporary “black henna” tattoo in the past.

Source:IS 4707 (Part 2):2025 Annex B, entry 10b · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Methyl-3-nitro-1-nitrosoguanidine (CAS No. 70-25-7)

CAS 70-25-7

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 688 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Methylamino-2-nitro-5- (2,3-dihydroxy-propyloxy)- benzene 2-nitro-5-glyceryl methylaniline (CAS No.: 80062-31-3)

CAS 80062-31-3 · EC 279-383-3

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: a)Hair dye substance in oxidative hair dye products; and b)Hair dye substance in non-oxidative hair dye products. | Maximum authorised concentration: b)1.0 percent | Other limitations/requirements: a)After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.8 percent For a) and b): 1)Do not use with nitrosating agents 2)Maximum nitrosamine and content: 50 μg/kg 3)Keep in nitrite-free containers. | Label conditions/warnings: a)To be printed on the label: The mixing ratio. “Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16 Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: 1)you have a rash on your face or sensitive, irritated and damaged scalp 2)you have ever experienced any reaction after colouring your hair;and 3)you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.”

Source:IS 4707 (Part 2):2025 Annex B, entry 282 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-N-Methylmorpholi nium- propylamino-4-hydroxyant- hraquinone, methyl sulfate Hydroxyanthraquinone ami- nopropyl Methyl Morpho- linium Methosulfate (CAS No.: 38866-20-5)

CAS 38866-20-5 · EC 254-161-9

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: a)Hair dye substance in non-oxidative hair dye products. | Maximum authorised concentration: 0.5 percent a)Do not use with | Other limitations/requirements: nitrosating agents b)Maximum nitrosamine and content: 50 μg/kg c)Keep in nitrite-free containers. | Label conditions/warnings: To be printed on the label: “Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: a)you have a rash on your face or sensitive, irritated and damaged scalp b)you have ever experienced any reaction after colouring your hair and c)you have experienced a reaction to a temporary “black henna” tattoo in the past.”

Source:IS 4707 (Part 2):2025 Annex B, entry 262 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Naphthalenol 1-Naphthol (CAS No. 90-15-3)

CAS 90-15-3 · EC 201-969-4

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: Hair dye substance in oxidative hair dye products | Other limitations/requirements: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0 percent | Label conditions/warnings: To be printed on the label: The mixing ratio. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: a)you have a rash on your face or sensitive, irritated and damaged scalp b)you have ever experienced any reaction after colouring your hair; and c)you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.

Source:IS 4707 (Part 2):2025 Annex B, entry 18 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Phenoxy-propan-2-ol ( ) Phenoxyisopropanol (CAS No. 770-35-4)

CAS 770-35-4 · EC 212-222-7

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: Rinse off products only Not to be used in oral products | Maximum authorised concentration: 2 percent For purposes other than | Other limitations/requirements: inhibiting the development of micro- organisms in the product. This purpose has to be apparent from the presentation of the product.

Source:IS 4707 (Part 2):2025 Annex B, entry 54 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Propanaminium, 3-[[9,10- dihydro-4-(methylamino)- 9,10-dioxo-1-anthracenyl] amino]-N,Ndimethyl-N- propyl-,Bromide HC Blue 16 (CAS No.: 502453-61-4)

CAS 502453-61-4

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: Hair dye substance in non- oxidative hair dye products | Maximum authorised concentration: 3.0 percent a)Do not use with | Other limitations/requirements: nitrosating agents b)Maximum nitrosamine content: 50 μg/k; and c)Keep in nitrite-free containers.

Source:IS 4707 (Part 2):2025 Annex B, entry 283 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Propanol, 3-[[4-[bis(2- hydro-xyethyl)amino]-2- (15) nitrophenyl]amino] HC Violet No 2 (CAS 104226-19-9)

CAS 104226-19-9 · EC 410-910-3

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: Hair dye substance in non- oxidative hair dye products | Maximum authorised concentration: 2.0 percent a) | Other limitations/requirements: o not use with nitrosating systems b)Maximum nitrosamine and content: 50 μg/kg c)Keepin nitrite-free containers. | Label conditions/warnings: Can cause allergic reaction

Source:IS 4707 (Part 2):2025 Annex B, entry 195 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Vinyl-2-pyrrolidone (CAS No. 88-12-0)

CAS 88-12-0 · EC 201-800-4

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1092 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-Vinylimidazole (CAS No. 1072-63-5).

CAS 1072-63-5 · EC 214-012-0

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1369 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-[(2-Chloro-4-nitrophenyl)azo]-2-naphthol (pigment red 4; CI 12085) (CAS No. 2814-77-9) and its salts when used as a substance in hair dye products

CAS 2814-77-9

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1318 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-[(3-Aminopropyl)amino]-4-(methylamino)anthraquinone (CAS No. 22366-99-0) and its salts, when used as a substance in hair dye products

CAS 22366-99-0 · EC 244-938-0

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1276 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-and 2-Naphthylamines and their salts (CAS No. 134-32-7/91-59-8)

CAS 134-32-7; 91-59-8

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 240 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-bromopropane; n-propyl bromide (CAS No. 106-94-5)

CAS 106-94-5

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1116 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1-chloro-4-nitrobenzene (CAS No. 100-00-5)

CAS 100-00-5

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1154 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

10046-00-1 [1], 20845-01-6 [2], 19098-16-9 [3], 53933-48-5 [4]) (3-Chloro-2-hydroxypropyl) trimethylammonium chloride (CAS No. 3327-22-8)

CAS 10046-00-1; 20845-01-6; 19098-16-9; 53933-48-5; 3327-22-8

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1513 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

101794-76-7), if they contain >0.005 percent benzo[a]pyrene w/w Aromatic hydrocarbons, C , polycyclic, mixed coal-tar pitch-polystyrene pyrolysis-derived (CAS No. 20-28

CAS 101794-76-7

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 625 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

11- -Hydroxypregn-4-ene-3,20-dione and its esters (CAS No. 80-75-1) α

CAS 80-75-1

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 381 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

16-18 Ioxynil and Ioxynil octanoate (ISO) (CAS No. 1689-83-4/3861-47-0)

CAS 1689-83-4; 3861-47-0

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1012 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1H-Indol-6-ol 6-Hydroxyindole (CAS No. 2380-86-1)

CAS 2380-86-1 · EC 417-020-4

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: Hair dye substance in oxidative hair dye products hair dye products | Other limitations/requirements: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.5 percent | Label conditions/warnings: To be printed on the label: The mixing ratio. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: a)you have a rash on your face or sensitive, irritated and damaged scalp b)you have ever experienced any reaction after colouring your hair and c)you have experienced a reaction to a temporary “black henna” tattoo in the past.

Source:IS 4707 (Part 2):2025 Annex B, entry 237 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1H-Indole-2,3-Dione Isatin (CAS No. 91-56-5)

CAS 91-56-5 · EC 202-077-8

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: Hair dye substance in non- oxidative hair dye products | Maximum authorised concentration: 1.6 percent | Label conditions/warnings: To be printed on the label: The mixing ratio. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if, a)you have a rash on your face or sensitive, irritated and damaged scalp b)you have ever experienced any reaction after colouring your hair and c)you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.

Source:IS 4707 (Part 2):2025 Annex B, entry 238 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1H-Indole-5,6-diol Dihydroxyindole (CAS No. 3131-52-0)

CAS 3131-52-0 · EC 412-130-9

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: a)Hair dye substance in oxidative hair dye products b)Hair dye substance in non- oxidative hair dye products | Maximum authorised concentration: b)0.5 percent | Other limitations/requirements: a)After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.5 percent | Label conditions/warnings: a)To be printed on the label: The mixing ratio. For a) and b): ‘Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: 1)you have a rash on your face or sensitive, irritated and damaged scalp 2)you have ever experienced any reaction after colouring your hair and 3)you have experienced a reaction to a temporary “black henna” tattoo in the past.

Source:IS 4707 (Part 2):2025 Annex B, entry 235 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1H-Pyrazole-4,5-diamine, 1- hexyl-, sulfate (2 : 1) 1-Hexyl 4,5-Diamino Pyrazole Sulfate (CAS No.: 1361000-03-4)

CAS 1361000-03-4

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

Conditions: Field of application/use: a)Hair dye substance in oxidative hair dye products | Other limitations/requirements: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.0percent | Label conditions/warnings: To be printed on the label: The mixing ratio. “Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: a)you have a rash on your face or sensitive, irritated and damaged scalp, b)you have ever experienced any reaction after colouring your hair, c)you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.”

Source:IS 4707 (Part 2):2025 Annex B, entry 291 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

1R,4S,5R,8S)-1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a- hexahydro-1,4:5,8-dimethanonaphthalene

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 196 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

2 Sultiame (*) (CAS No. 61-56-3)

CAS 61-56-3

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 306 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

2) Cells, tissues or products of human origin

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 410 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

2, -Bioxirane (1,2:3,4-Diepoxybutane) (CAS No. 1464-53-5) 2′

CAS 1464-53-5

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 652 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

2, 68307-99-3, 68308-00-9, 68308-01-0, 68308-10-1, 68308-03-2, 68308-04-3, 68308-05-4, 68308-06-5, 68308-07-6, 68308-09-8, 68308-11-2, 68308-12-3, 68409-99-4, 68475-57-0, 68475-58-1, 68475-59-2, 68475-60-5, 68476-26-6, 68476-29-9, 68476-40-4, 68476-42-6, 68476-49-3, 68476-85-7, 68476-86-8, 68477-33-8, 68477-35-0, 68477-69-0, 68477-70-3, 68477-71-4, 68477-72-5, 68308-08-7) Tris[2-chloro-1-(chloromethyl)ethyl] phosphate (CAS No. 13674-87-8)

2, 68307-99-3, 68308-00-9, 68308-01-0, 68308-10-1, 68308-03-2, 68308-04-3, 68308-05-4, 68308-06-5, 68308-07-6, 68308-09-8, 68308-11-2, 68308-12-3, 68409-99-4, 68475-57-0, 68475-58-1, 68475-59-2, 68475-60-5, 68476-26-6, 68476-29-9, 68476-40-4, 68476-42-6,

CAS 68307-99-3; 68308-00-9; 68308-01-0; 68308-10-1; 68308-03-2; 68308-04-3; 68308-05-4; 68308-06-5; 68308-07-6; 68308-09-8; 68308-11-2; 68308-12-3; 68409-99-4; 68475-57-0; 68475-58-1; 68475-59-2; 68475-60-5; 68476-26-6; 68476-29-9; 68476-40-4; 68476-42-6; 68476-49-3; 68476-85-7; 68476-86-8; 68477-33-8; 68477-35-0; 68477-69-0; 68477-70-3; 68477-71-4; 68477-72-5; 68308-08-7; 13674-87-8

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1546 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

2,2 -[(3,3 - -biphenyl]- -diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide] ’ ’ Dichloro[1,1’ 4,4’ (pigment yellow 13; CI 21100) (CAS No. 5102-83-0) when used as a substance in hair dye products

CAS 5102-83-0

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1324 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

2,2'-((3-Chloro-4-((2,6-dichloro-4-nitrophenyl)azo)phenyl)imino)bisethanol (CAS No. 23355-64-8) (disperse brown 1) and its salts, when used as a substance in hair dye products.

CAS 23355-64-8 · EC 245-604-7

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1233 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane (hexachlorophene (*)) (CAS No. 70-30-4)

CAS 70-30-4

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 368 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'- diyl)bis(azo)]bis[3-oxo-N-phenylbutanamide] (pigment yellow 12)(CAS No. 6358-85-6) and its salts, when used as a substance in hair dye products.

CAS 6358-85-6 · EC 228-787-8

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 1236 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

2,2,2-Tribromoethanol (tribromoethyl alcohol) (CAS No. 75-80-9)

CAS 75-80-9

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 324 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31

2,2,2-Trichloroethane-1,1-diol (CAS No. 302-17-0)

CAS 302-17-0

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

Conditions: Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Source:IS 4707 (Part 2):2025 Annex A, entry 77 · version IS 4707 (Part 2):2025, fifth revision · effective Aug. 9, 2025 · source checked 2026-08-31