CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
ProhibitedBinding ruleINOriginal is EnglishOfficial-source import checked

10046-00-1 [1], 20845-01-6 [2], 19098-16-9 [3], 53933-48-5 [4]) (3-Chloro-2-hydroxypropyl) trimethylammonium chloride (CAS No. 3327-22-8)

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

All India recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.
Conditions and restrictions
Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Substance identity

Official source name
10046-00-1 [1], 20845-01-6 [2], 19098-16-9 [3], 53933-48-5 [4]) (3-Chloro-2-hydroxypropyl) trimethylammonium chloride (CAS No. 3327-22-8)
CAS
10046-00-1; 20845-01-6; 19098-16-9; 53933-48-5; 3327-22-8
EC
Not supplied in this source row
Identity mapping
standalone:official_bis_record
Search this identity across the siteCAS 10046-00-1CAS 20845-01-6CAS 19098-16-9CAS 53933-48-5CAS 3327-22-8

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

6 market datasets
PubChem 2D chemical structure for CAS 10046-00-1
CAS 10046-00-1PubChem CID 159255

Verified chemistry for CAS 10046-00-1

Hydroxylamine, sulfate (1:1)

IUPAC name
hydroxylamine;sulfuric acid
Molecular formula
H5NO5S
Molecular weight
131.11 g/mol
Exact mass
130.98884343 Da
Monoisotopic mass
130.98884343 Da
Topological polar surface area
129.0 Ų
Molecular complexity
83.0
Formal charge
0
Hydrogen-bond donors
4
Hydrogen-bond acceptors
6
Rotatable bonds
0
Heavy atoms
7
Covalent units
2

Names and synonyms reported to PubChem

Hydroxylammonium hydrogensulphateHydroxylammonium acid sulfateEINECS 233-154-4Hydroxylamine, sulfate (1:1) (salt)RefChem:789514Hydroxylamine sulfate (1:1)H5NO5SHydroxyamine sulfate
3 more reported names
hydroxylamin hydrogensulfateNH2OH H2SO4Sulfuric acid--hydroxylamine (1/1)
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
NO.OS(=O)(=O)O
InChI
InChI=1S/H3NO.H2O4S/c1-2;1-5(2,3)4/h2H,1H2;(H2,1,2,3,4)
InChIKey
NXPHCVPFHOVZBC-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match159255

Attributed physical-property, hazard, environmental and use annotations.

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBINo exact record2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 19098-16-9
CAS 19098-16-9PubChem CID 167787

Verified chemistry for CAS 19098-16-9

Hydroxylamine, phosphate (1:1)

IUPAC name
hydroxylamine;phosphoric acid
Molecular formula
H6NO5P
Molecular weight
131.03 g/mol
Exact mass
130.99835929 Da
Monoisotopic mass
130.99835929 Da
Topological polar surface area
124.0 Ų
Molecular complexity
51.0
Formal charge
0
Hydrogen-bond donors
5
Hydrogen-bond acceptors
6
Rotatable bonds
0
Heavy atoms
7
Covalent units
2

Names and synonyms reported to PubChem

RefChem:1087073242-818-2Hydroxylamine phosphateHydroxylamine acid phosphateHydroxylamine, phosphate (salt)Hydroxylamine, phosphate (1:?)EINECS 242-818-2Hydroxylammonium dihydrogen phosphate
3 more reported names
Hydroxylamine, phosphate (1:1) (salt)Hydroxylamine dihydrogen phosphatePhosphoric acid--hydroxylamine (1/1)
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
NO.OP(=O)(O)O
InChI
InChI=1S/H3NO.H3O4P/c1-2;1-5(2,3)4/h2H,1H2;(H3,1,2,3,4)
InChIKey
HYYHQASRTSDPOD-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 20845-01-6
CAS 20845-01-6PubChem CID 11252585

Verified chemistry for CAS 20845-01-6

Hydroxylamine, phosphate (3:1) (salt) (8CI,9CI)

IUPAC name
hydroxylamine;phosphoric acid
Molecular formula
H12N3O7P
Molecular weight
197.09 g/mol
Exact mass
197.04128673 Da
Monoisotopic mass
197.04128673 Da
Topological polar surface area
217.0 Ų
Molecular complexity
51.0
Formal charge
0
Hydrogen-bond donors
9
Hydrogen-bond acceptors
10
Rotatable bonds
0
Heavy atoms
11
Covalent units
4

Names and synonyms reported to PubChem

Hydroxylamine, phosphate (3:1) (salt)Hydroxylammonium hydrogensulfateXBUFCZMOAHHGMX-UHFFFAOYSA-NHydroxylamine phosphate, >=95.0% (RT)Hydroxylamine phosphate salt (3:1), 97%
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
NO.NO.NO.OP(=O)(O)O
InChI
InChI=1S/3H3NO.H3O4P/c3*1-2;1-5(2,3)4/h3*2H,1H2;(H3,1,2,3,4)
InChIKey
XBUFCZMOAHHGMX-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 3327-22-8
CAS 3327-22-8PubChem CID 18732

Verified chemistry for CAS 3327-22-8

(3-Chloro-2-hydroxypropyl)trimethylammonium chloride

IUPAC name
(3-chloro-2-hydroxypropyl)-trimethylazanium chloride
Molecular formula
C6H15Cl2NO
Molecular weight
188.09 g/mol
Exact mass
187.0530695 Da
Monoisotopic mass
187.0530695 Da
Topological polar surface area
20.2 Ų
Molecular complexity
79.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Rotatable bonds
3
Heavy atoms
10
Covalent units
2

Names and synonyms reported to PubChem

Dextrosil1-Propanaminium, 3-chloro-2-hydroxy-N,N,N-trimethyl-, chloride3-Chloro-2-hydroxypropylammonium chlorideAPK4X6ZD793-Chloro-2-hydroxypropyltrimethylammonium chlorideNSC-51216AMMONIUM, (3-CHLORO-2-HYDROXYPROPYL)TRIMETHYL-, CHLORIDE1-Propanaminium, 3-chloro-2-hydroxy-N,N,N-trimethyl-, chloride (1:1)
16 more reported names
CHPTAC cpdRefChem:691063-Cl-2-HP-TACl222-048-33-Chloro-2-hydroxypropyltrimethyl ammonium chlorideDextrosil KA(3-Chloro-2-hydroxypropyl)-N,N,N-trimethylammonium chloride3-Chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride(65% in water)(3-chloro-2-hydroxypropyl)-trimethylazanium;chlorideLevocarnitine Impurity 83-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride2-Hydroxy-3-chloropropyltrimethylammonium chlorideTrimethyl(2-hydroxy-3-chloropropyl)ammonium chlorideCatiomaster CC6H15Cl2NOVerolan KAF
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C[N+](C)(C)CC(CCl)O.[Cl-]
InChI
InChI=1S/C6H15ClNO.ClH/c1-8(2,3)5-6(9)4-7;/h6,9H,4-5H2,1-3H3;1H/q+1;/p-1
InChIKey
CSPHGSFZFWKVDL-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 53933-48-5
CAS 53933-48-5PubChem CID 6452918

Verified chemistry for CAS 53933-48-5

Hydroxylammonium 4-methylbenzenesulphonate

IUPAC name
hydroxyazanium;4-methylbenzenesulfonate
Molecular formula
C7H11NO4S
Molecular weight
205.23 g/mol
Exact mass
205.04087901 Da
Monoisotopic mass
205.04087901 Da
Topological polar surface area
113.0 Ų
Molecular complexity
195.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Rotatable bonds
0
Heavy atoms
13
Covalent units
2

Names and synonyms reported to PubChem

EINECS 258-872-5RefChem:147205258-872-5hydroxylammonium tosylatePEHQDJBIJOXLEI-UHFFFAOYSA-MHydroxyammonium 4-methylbenzenesulphonateDB-243595Hydroxyammonium 4-methylbenzene-1-sulfonate
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
CC1=CC=C(C=C1)S(=O)(=O)[O-].[NH3+]O
InChI
InChI=1S/C7H8O3S.H4NO/c1-6-2-4-7(5-3-6)11(8,9)10;1-2/h2-5H,1H3,(H,8,9,10);2H,1H3/q;+1/p-1
InChIKey
PEHQDJBIJOXLEI-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
India BIS IS 4707 cosmetic ingredient standards
Source reference
IS 4707 (Part 2):2025 Annex A, entry 1513
Source record ID
annex-a:1513
Source version
IS 4707 (Part 2):2025, fifth revision
Source language
English
Translation status
Original is English
Effective date
2025-08-09
Source updated
2025-08-09
Snapshot checked
2026-08-31 15:30 UTC
Validation method
206 text layers; Annex A 1-1614 and Annex B 1-313 with seven lettered source rows
SHA-256
905dd0326361c53da8a354b948331946951ac3ae27d60d8e2474efb051239603

Registered dataset notes

Dataset coverage
Complete current Part 2:2025 Annex A prohibited and Annex B restricted rows; Parts 1, 3 and 4 remain linked official checks
Authority note
Indian Standards referenced by the cosmetics regulatory framework; use the controlled current editions
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1931
current India records
1614
records marked Prohibited
1931
records from this source version
1836
market records with CAS identity

Status distribution

Prohibited: 1614Restricted: 317

Condition text is present on 1931 of 1931 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

India market context

Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4

Coverage version: Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

All 1,614 prohibited Annex A rows and 317 numbered/lettered restricted Annex B rows from IS 4707 Part 2:2025; official checks remain for colourants, preservatives and UV filters in Parts 1, 3 and 4.

Verification checklist

  1. Confirm product class and current Cosmetics Rules/gazette amendments.
  2. Check all applicable parts of IS 4707 by exact identity.
  3. Apply Schedule S/other finished-product standards where relevant.
  4. Verify licence/import registration, labelling and testing requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “10046-00-1 [1], 20845-01-6 [2], 19098-16-9 [3], 53933-48-5 [4]) (3-Chloro-2-hydroxypropyl) trimethylammonium chloride (CAS No. 3327-22-8)” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm product class and current Cosmetics Rules/gazette amendments.
  3. Check all applicable parts of IS 4707 by exact identity.
  4. Apply Schedule S/other finished-product standards where relevant.
  5. Verify licence/import registration, labelling and testing requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

The record cites IS 4707 (Part 2):2025 Annex A, entry 1513, source version IS 4707 (Part 2):2025, fifth revision. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

10046-00-1 [1], 20845-01-6 [2], 19098-16-9 [3], 53933-48-5 [4]) (3-Chloro-2-hydroxypropyl) trimethylammonium chloride (CAS No. 3327-22-8). IS 4707 (Part 2):2025 Annex A, entry 1513. India. Source version IS 4707 (Part 2):2025, fifth revision. CosIng Checker regulatory record: https://cosingchecker.com/regulations/in/records/16107/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for India

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: IS 4707 (Part 2):2025, fifth revision
  • Effective date: 2025-08-09

What it does not prove

The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source