What does the restriction note for DIHYDROXYINDOLE mean?

The restriction field for DIHYDROXYINDOLE reads: Annex III/207. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 3131-52-0?

CAS 3131-52-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains DIHYDROXYINDOLE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3336506/06/2019

DIHYDROXYINDOLE

1H-Indole-5,6-diol

DIHYDROXYINDOLE is linked to 1 EU annex record on this page. Inventory note: Annex III/207.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Restricted Open this evidence	1	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Restricted Open this evidence	1	English
ASEAN	Evidence linked Restricted Open this evidence	1	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Evidence linked Restricted Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Restricted Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 3131-52-0

CAS 3131-52-0PubChem CID 114683

5,6-Dihydroxyindole

5,6-dihydroxyindole is a dihydroxyindole. It has a role as a mouse metabolite. — ChEBI

IUPAC name: 1H-indole-5,6-diol

Molecular formula: C8H7NO2
Molecular weight: 149.15 g/mol
Exact mass: 149.047678466 Da
XLogP3: 1.3
Topological polar surface area: 56.3 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

Dopamine lutine3H-INDOLE-5,6-DIOLZ3OC8499KGIMEXINE OAYCHEBI:27404RefChem:587786CHEBI:23781412-130-9

16 more reported names

Dihydroxyindoledhi5,6-Dihydroxy-1H-indole5,6-dihydroxy indoleCS-W018811AC-22682D-3560UNII-Z3OC8499KGindole-5,6-diolA5673EC 412-130-9Calcein Red? (sodium salt)Dopamine lutine;Indole-5,6-diolHY-W018025DS-10556DB-008889

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:27404
ChEMBL:CHEMBL92636
EPA DTXSID:DTXSID20185242
PubMed:38163560
PubMed:22651227
PubMed:22611345
PubMed:22523636
PubMed:22428043
PubMed:22383881
PubMed:22282089
PubMed:22017184
PubMed:21976956
PubMed:21941589
PubMed:21923179
PubMed:21806060

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DIHYDROXYINDOLE

INCI name

DIHYDROXYINDOLE

Description

1H-Indole-5,6-diol

Record provenance

Inventory reference: 33365
Imported identity: DIHYDROXYINDOLE
Source update: 06/06/2019

European Commission CosIng source notes

Annex records for DIHYDROXYINDOLE

Annex III Restriction reference

Entry 207

DIHYDROXY-INDOLE

CAS: 3131-52-0

EC: 412-130-9

Key data

CAS

3131-52-0

412-130-9

Restriction

Annex III/207

Function

HAIR DYEING: Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#8734 · DIHYDROXYINDOLE

Ingredients with overlapping formulation functions

COCHINEALCOLORANT, HAIR DYEING

COPPER TETRAPEPTIDE-52 DIMERHAIR CONDITIONING, HAIR DYEING

CURRY REDHAIR DYEING

DIHYDROXYACETONEHAIR DYEING, SKIN CONDITIONING - MISCELLANEOUS, TANNING

DIHYDROXYINDOLINEHAIR DYEING

DIHYDROXYINDOLINE HBRHAIR DYEING

DIMETHYLPIPERAZINIUM AMINOPYRAZOLOPYRIDINE HCLHAIR DYEING

DIRECT BLACK 51HAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How DIHYDROXYINDOLE appears in the CosIng inventory

The CosIng inventory lists DIHYDROXYINDOLE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DIHYDROXYINDOLE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DIHYDROXYINDOLE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for DIHYDROXYINDOLE reads: "Annex III/207". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, DIHYDROXYINDOLE carries the following function designation(s):

HAIR DYEING

CAS 3131-52-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for DIHYDROXYINDOLE

This page combines the CosIng inventory entry for DIHYDROXYINDOLE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research DIHYDROXYINDOLE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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