ASEAN cosmetic ingredient regulations

4-tert-Butylbenzoic acid

CAS 98-73-7 · EC 202-696-3

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1549 · version 2026-1 · source checked 2026-08-30

4-tert-Butylphenol

CAS 98-54-4

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 340 · version 2026-1 · source checked 2026-08-30

4-tert-Butylpyrocatechol

CAS 98-29-3

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 341 · version 2026-1 · source checked 2026-08-30

4’-tert-Butyl-2’,6’-dimethyl-3’,5’- dinitroacetophenone Musk ketone CAS No 81-14-1

CAS 81-14-1 · EC 201-328-9

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: All cosmetic products, with the exception of oral care products · (a) 1.4 % in fine fragrance (b) 0.56 % in eau de toilette (c) 0.042 % in other products

Source:ASEAN Annex III, reference 97 · version 2026-1 · source checked 2026-08-30

5,12-Dihydroquino[2,3-b]acridine-7,14-dione (Pigment Violet 19;

CAS 1047-16-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1366 · version 2026-1 · source checked 2026-08-30

5,5'-Di-isopropyl-2,2'-dimethylbiphenyl-4,4'-diyl dihypoiodate

CAS 552-22-7

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 361 · version 2026-1 · source checked 2026-08-30

5,5-Diphenyl-4-imidazolidone

CAS 3254-93-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 160 · version 2026-1 · source checked 2026-08-30

5,6,12,13-Tetrachloroanthra(2,1,9-def:6,5,10-

CAS 115662-06-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1003 · version 2026-1 · source checked 2026-08-30

5-((4-(Dimethylamino)phenyl)azo)-1,4-dimethyl-1H-1,2,4-

CAS 12221-52-2

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1292 · version 2026-1 · source checked 2026-08-30

5-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidine)-3-fluoro-2-

CAS 41107-56-6

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1064 · version 2026-1 · source checked 2026-08-30

5-(3-Butyryl-2,4,6-trimethylphenyl)-2-[1-(ethoxyimino)propyl]-3-

CAS 138164-12-2

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1190 · version 2026-1 · source checked 2026-08-30

5-(alpha, beta-Dibromophenethyl)-5-methylhydantoin

CAS 511-75-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 119 · version 2026-1 · source checked 2026-08-30

5-Amino-2,6-dimethoxy-3-hydroxypyridine and its salts, when

CAS 104333-03-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1308 · version 2026-1 · source checked 2026-08-30

5-Amino-4-chloro-2-methylphenol hydrochloride 5-Amino-4-Chloro-o-Cresol HCl CAS No 110102-85-7

CAS 110102-85-7

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5% (calculated as hydrochloride) The direction for use “wear suitable gloves” must be included in label or leaflet text. · The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 258 · version 2026-1 · source checked 2026-08-30

5-Amino-4-fluoro-2-methylphenol sulfate, when used as a

CAS 163183-01-5

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1222 · version 2026-1 · source checked 2026-08-30

5-Amino-o-cresol 4-Amino-2-hydroxytoluene CAS No 2835-95-2

CAS 2835-95-2 · EC 220-618-6

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5 % The direction for use “wear suitable gloves” must be included in label or leaflet text. · The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 243 · version 2026-1 · source checked 2026-08-30

5-Bromo-5-nitro-1,3 dioxane CAS No. 30007-47-7

CAS 30007-47-7 · EC 250-001-7

ASEAN Annex VI lists this record among preservatives allowed for cosmetic use. Member-state transition rules and deviations still require local verification.

Conditions: 0.1% · Rinse-off products only Avoid formation of nitrosamines

Source:ASEAN Annex VI, reference 20 · version 2026-1 · source checked 2026-08-30

5-Chloro-1,3-dihydro-2H-indol-2-one

CAS 17630-75-0

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1034 · version 2026-1 · source checked 2026-08-30

5-Chloro-2- (2,4- dichlorophenoxy) phenol (INCI) Triclosan (INN) CAS No. 3380-34-5

CAS 3380-34-5 · EC 222-182-2

ASEAN Annex VI lists this record among preservatives allowed for cosmetic use. Member-state transition rules and deviations still require local verification.

Conditions: (a) 0.3% (b) 0.2% · (a) Toothpastes Hand soaps Body soaps/Shower gels Deodorants (non- spray) Face powders and blemish concealers Nail products for cleaning the fingernails and toenails before the application of artificial nail systems Shampoo Hair conditioner Facial cleanser (b) Mouthwashes

Source:ASEAN Annex VI, reference 25 · version 2026-1 · source checked 2026-08-30

5-Chloro-2- (2,4- dichlorophenoxy) phenol Triclosan CAS No 3380-34-5 Singapore: Not permitted for non- preservative use.

CAS 3380-34-5 · EC 222-182-2

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: (a) Toothpastes Hand soaps Body soaps/Shower gels Deodorants (non-spray) Face powders and blemish concealers Nail products for cleaning the fingernails and toenails before the application of artificial nail systems Shampoos Hair Conditioners Facial Cleansers (b) Mouthwashes · (a) 0.3 % (b) 0.2 %

Source:ASEAN Annex III, reference 288 · version 2026-1 · source checked 2026-08-30

5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole

CAS 2593-15-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1054 · version 2026-1 · source checked 2026-08-30

5-Ethyl-3,7-dioxa-1-azabicyclo [3.3.0] octane CAS No. 7747-35-5

CAS 7747-35-5 · EC 231-810-4

ASEAN Annex VI lists this record among preservatives allowed for cosmetic use. Member-state transition rules and deviations still require local verification.

Conditions: 0.3% · Prohibited in oral hygiene products and in products intended to come into contact with mucous membranes

Source:ASEAN Annex VI, reference 49 · version 2026-1 · source checked 2026-08-30

5-Hydroxy-1,4-benzodioxane and its salts, when used as a

CAS 10288-36-5

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1246 · version 2026-1 · source checked 2026-08-30

5-Methyl-2,3-hexanedione, when used as a fragrance ingredient.

CAS 13706-86-0

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 447 · version 2026-1 · source checked 2026-08-30

5-Nitro-o-toluidine [1] 5-Nitro-o-toluidine hydrochloride [2]

CAS 99-55-8

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1195 · version 2026-1 · source checked 2026-08-30

5-Nitroacenaphthene

CAS 602-87-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 691 · version 2026-1 · source checked 2026-08-30

5-[(2-Hydroxyethyl)amino]-o-cresol 2-Methyl-5-hydroxyethylaminophenol CAS No 55302-96-0

CAS 55302-96-0 · EC 259-583-7

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5 % • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg(21) • Keep in nitrite-free containers The direction for use “wear suitable gloves” must be included in label or leaflet text. · The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 232 · version 2026-1 · source checked 2026-08-30

5-fluoro-1,3-dimethyl-N-[2-(4- methylpentan-2-yl) phenyl]-1H-

CAS 494793-67-8

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1674 · version 2026-1 · source checked 2026-08-30

5-tert-Butyl-1,2,3-trimethyl-4,6-dinitrobenzene (Musk tibetene)

CAS 145-39-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 422 · version 2026-1 · source checked 2026-08-30

5-tert-Butyl-2,4,6-trinitro-m-xylene Musk xylene CAS No 81-15-2

CAS 81-15-2 · EC 201-329-4

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: All cosmetic products, with the exception of oral care products · (a) 1.0 % in fine fragrance (b) 0.4 % in eau de toilette (c) 0.03 % in other products

Source:ASEAN Annex III, reference 96 · version 2026-1 · source checked 2026-08-30

6,10-Dimethyl-3,5,9-undecatrien-2-one, when used as a

CAS 141-10-6

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 433 · version 2026-1 · source checked 2026-08-30

6,6'-Bis(diazo-5,5',6,6'-tetrahydro-5,5'-dioxo)[methylene-bis(5-

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1497 · version 2026-1 · source checked 2026-08-30

6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol;[DBMC]

CAS 19-47-1

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1682 · version 2026-1 · source checked 2026-08-30

6,6-Dibromo-4,4-dichloro-2,2’-methylene- diphenol (Bromochlorophen) CAS No. 15435-29-7

CAS 15435-29-7 · EC 239-446-8

ASEAN Annex VI lists this record among preservatives allowed for cosmetic use. Member-state transition rules and deviations still require local verification.

Conditions: 0.1%

Source:ASEAN Annex VI, reference 37 · version 2026-1 · source checked 2026-08-30

6-(2-Chloroethyl)-6-(2-methoxyethoxy)-2,5,7,10-tetraoxa-6-

CAS 37894-46-5

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 452 · version 2026-1 · source checked 2026-08-30

6-(Piperidinyl)-2,4-pyrimidinediamine-3-oxide (minoxidil) and its

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 372 · version 2026-1 · source checked 2026-08-30

6-Amino-2-(2,4-dimethylphenyl)-1H-benz[de]isoquinoline-

CAS 2478-20-8 · EC 219-607-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1277 · version 2026-1 · source checked 2026-08-30

6-Amino-o-cresol and its salts, when used as a substance in

CAS 17672-22-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1315 · version 2026-1 · source checked 2026-08-30

6-Chloro-2-(6-chloro-4-methyl-3-oxobenzo[b]thien-2(3H)-

CAS 2379-74-0 · EC 219-163-6

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1365 · version 2026-1 · source checked 2026-08-30

6-Glycidyloxynapht-1-yl oxymethyloxirane

CAS 27610-48-6

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1470 · version 2026-1 · source checked 2026-08-30

6-Hydroxy-1-(3-Isopropoxypropyl)-4-methyl-2-oxo-5-[4-

CAS 85136-74-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 756 · version 2026-1 · source checked 2026-08-30

6-Hydroxy-3,4-dimethyl-2-pyridone 2,6-Dihydroxy-3,4-dimethylpyridine CAS No 84540-47-6

CAS 84540-47-6 · EC 283-141-2

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.0% The direction for use “wear suitable gloves” must be included in label or leaflet text. · The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 218 · version 2026-1 · source checked 2026-08-30

6-Isopropyl-2-decahydronaphthalenol, when used as a

CAS 34131-99-2

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 441 · version 2026-1 · source checked 2026-08-30

6-Methoxy-2,3-pyridinediamine and its HCl salt, when used as a

CAS 94166-62-8 · EC 303-358-9

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1212 · version 2026-1 · source checked 2026-08-30

6-Methoxy-N2- methyl-2,3- pyridinediamine hydrochloride and dihydrochloride salt 6-Methoxy-2-Methylamino-3- Aminopyridine HCl CAS No. 90817-34-8 / 83732-72-3

CAS 90817-34-8; 83732-72-3

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: a) Hair dye substance in oxidative hair dye products b) Hair dye substance in non-oxidative hair Use for dyeing eyelashes and eyebrows is not permitted. · b) 0.68 as free base (1.0% as dihydrochloride) · For (a): After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.68% calculated as free base (1,0 % as dihydrochloride). For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg /kg(21) • Keep in nitrite- free containers The free base and salts of this hair dye ingredient, unless prohibited in Annex II, are permitted for use. The direction for use “wear suitable gloves” must be included in label or leaflet text. · (a) To be printed on the label: The mixing ratio. “Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16 Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.” Do not use to dye eyelashes or eyebrows b) Can cause allergic reaction Do not use to dye eyelashes or eyebrows

Source:ASEAN Annex III, reference 203 · version 2026-1 · source checked 2026-08-30

6-Methoxy-m-toluidine; (p-Cresidine)

CAS 120-71-8

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1162 · version 2026-1 · source checked 2026-08-30

6-Methylcoumarin CAS No 92-48-8

CAS 92-48-8 · EC 202-158-8

ASEAN Annex III lists this record among substances allowed only under restrictions and conditions. Member-state transition rules and deviations still require local verification.

Conditions: Oral hygiene products · 0.003%

Source:ASEAN Annex III, reference 46 · version 2026-1 · source checked 2026-08-30

6-Nitro-2,5-pyridinediamine and its salts, when used as a

CAS 69825-83-8

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1321 · version 2026-1 · source checked 2026-08-30

6-Nitro-o-toluidine

CAS 570-24-1 · EC 209-329-6

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1235 · version 2026-1 · source checked 2026-08-30

6-[(C10-C13)-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-

CAS 2156592-54-8

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

Source:ASEAN Annex II, reference 1708 · version 2026-1 · source checked 2026-08-30