Canada cosmetic ingredient regulations

Mephenesin and its esters

Canada Hotlist: Mephenesin and its esters

CAS 59-47-2

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 301 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Meprobamate

Canada Hotlist: Meprobamate

CAS 57-53-4

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 302 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Mercury and its compounds

Canada Hotlist: Mercury and its compounds

CAS 7439-97-6; 21908-53-2; 62-38-4; 94-43-9; 102-98-7; 6273-99-0; 54-64-8

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Conditions: Synonyms or related compounds: Mercuric oxide; Phenyl mercuric acetate; Phenyl mercuric benzoate; Phenyl mercuric borate; Thimerosal

Source:Hotlist prohibited entry 303 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Mescaline and its salts

Canada Hotlist: Mescaline and its salts

CAS 54-04-6

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Conditions: Synonyms or related compounds: 3,4,5-trimethoxyphenethylamine

Source:Hotlist prohibited entry 304 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Metaldehyde

Canada Hotlist: Metaldehyde

CAS 9002-91-9

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 305 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Metamfepramone and its salts

Canada Hotlist: Metamfepramone and its salts

CAS 15351-09-4

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 306 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Metethoheptazine and its salts

Canada Hotlist: Metethoheptazine and its salts

CAS 509-84-2

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 307 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Metformin and its salts

Canada Hotlist: Metformin and its salts

CAS 657-24-9

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 308 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Methapyrilene and its salts

Canada Hotlist: Methapyrilene and its salts

CAS 91-80-5

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 309 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Metheptazine and its salts

Canada Hotlist: Metheptazine and its salts

CAS 469-78-3

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 310 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Methocarbamol

Canada Hotlist: Methocarbamol

CAS 532-03-6

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 311 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Methotrexate

Canada Hotlist: Methotrexate

CAS 59-05-2 · EC 200-413-8 (I)

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 312 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Methoxydiglycol

Canada Hotlist: Methoxydiglycol

CAS 111-77-3 · EC 203-906-6

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Conditions: Synonyms or related compounds: Diethylene glycol monomethyl ether; DEGME

Source:Hotlist prohibited entry 313 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Methoxyethanol

Canada Hotlist: Methoxyethanol

CAS 109-86-4

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 314 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Methoxyethanol acetate

Canada Hotlist: Methoxyethanol acetate

CAS 110-49-6 · EC 203-772-9

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 315 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Methyl methacrylate monomer

Canada Hotlist: Methyl methacrylate monomer

CAS 80-62-6 · EC 201-297-1

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 316 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Methyl-trans-2-butenoate

Canada Hotlist: Methyl-trans-2-butenoate

CAS 623-43-8

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 319 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Methyloxirane monomer

Canada Hotlist: Methyloxirane monomer

CAS 75-56-9

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Conditions: Synonyms or related compounds: Propylene oxide

Source:Hotlist prohibited entry 317 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Methylphenidate and its salts

Canada Hotlist: Methylphenidate and its salts

CAS 113-45-1

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 318 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Methyprylon and its salts

Canada Hotlist: Methyprylon and its salts

CAS 125-64-4

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 320 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Metyrapone

Canada Hotlist: Metyrapone

CAS 54-36-4

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 321 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Minoxidil, its salts and derivatives

Canada Hotlist: Minoxidil, its salts and derivatives

CAS 38304-91-5 · EC 253-874-2

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 322 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Mofebutazone

Canada Hotlist: Mofebutazone

CAS 2210-63-1

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 323 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Morpholine and its salts

Canada Hotlist: Morpholine and its salts

CAS 110-91-8 · EC 203-815-1

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 324 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Musk ambrette

Canada Hotlist: Musk ambrette

CAS 83-66-9

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Conditions: Synonyms or related compounds: 4- tert -butyl-3-methoxy-2,6-dinitrotoluene

Source:Hotlist prohibited entry 325 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Musk tibetene

Canada Hotlist: Musk tibetene

CAS 145-39-1

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Conditions: Synonyms or related compounds: 1- tert -butyl-3,4,5-trimethyl-2,6-dinitrobenzene

Source:Hotlist prohibited entry 326 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts

Canada Hotlist: N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts

CAS 126-85-2

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Conditions: Synonyms or related compounds: Nitrogen mustard N-oxide

Source:Hotlist prohibited entry 327 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

N-5-Chlorobenzoxazol-2-ylacetamide and its salts

Canada Hotlist: N-5-Chlorobenzoxazol-2-ylacetamide and its salts

CAS 35783-57-4

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 328 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Nalorphine, its salts and ethers

Canada Hotlist: Nalorphine, its salts and ethers

CAS 62-67-9

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 329 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Naphazoline and its salts

Canada Hotlist: Naphazoline and its salts

CAS 835-31-4

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 330 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Naphthalene

Canada Hotlist: Naphthalene

CAS 91-20-3

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 331 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Narcotics, natural and synthetic

Canada Hotlist: Narcotics, natural and synthetic

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 332 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Neodymium and its salts

Canada Hotlist: Neodymium and its salts

CAS 7440-00-8

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 333 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Neostigmine and its salts

Canada Hotlist: Neostigmine and its salts

CAS 59-99-4

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 334 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Nerium oleander , its extracts and its glycosides

Canada Hotlist: Nerium oleander , its extracts and its glycosides

CAS 465-16-7; 84929-39-5 · EC 284-522-6

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Conditions: Synonyms or related compounds: Oleandrin; Digitoxigenin; Neriin; Folinerin; Rosagenin

Source:Hotlist prohibited entry 335 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Nicotine and its salts

Canada Hotlist: Nicotine and its salts

CAS 54-11-5

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 336 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Nitrites, amyl

Canada Hotlist: Nitrites, amyl

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 337 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Nitrites, inorganic, except sodium nitrite

Canada Hotlist: Nitrites, inorganic, except sodium nitrite

CAS 14797-65-0

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 338 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Nitrobenzene

Canada Hotlist: Nitrobenzene

CAS 98-95-3

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 339 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Nitrocresols and their alkali metal salts

Canada Hotlist: Nitrocresols and their alkali metal salts

CAS 12167-20-3; 119-33-5; 4920-77-8; 2042-14-0; 2581-34-2; 5428-54-6; 700-38-9; 2666-76-4 · EC 218-044-6

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Conditions: Synonyms or related compounds: 2-Nitro-4-cresol; 2-Nitro-m-cresol; 3-Nitro-p-cresol; 4-Nitro-m-cresol; 4-Nitro-o-cresol; 5-Nitro-o-cresol; 6-Nitro-m-cresol; Sodium 4-nitro-m-cresolate

Source:Hotlist prohibited entry 340 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Nitrofurantoin

Canada Hotlist: Nitrofurantoin

CAS 67-20-9

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 341 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Nitroglycerin

Canada Hotlist: Nitroglycerin

CAS 55-63-0

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 342 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Nitrosamines

Canada Hotlist: Nitrosamines

CAS 64091-91-4; 35576-91-1; 930-55-2; 100-75-4; 10595-95-6; 59-89-2; 621-64-7; 924-16-3; 55-18-5; 1116-54-7; 62-75-9

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Conditions: Synonyms or related compounds: N-nitrosodiethanolamine

Source:Hotlist prohibited entry 343 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Nitrostilbenes, their homologues and their derivatives

Canada Hotlist: Nitrostilbenes, their homologues and their derivatives

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 344 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Nitroxoline and its salts

Canada Hotlist: Nitroxoline and its salts

CAS 4008-48-4

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 345 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Noradrenaline and its salts

Canada Hotlist: Noradrenaline and its salts

CAS 51-41-2

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 346 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Noscapine and its salts

Canada Hotlist: Noscapine and its salts

CAS 128-62-1

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 347 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

O , O '-Diacetyl-N-allyl-N-normorphine

Canada Hotlist: O , O '-Diacetyl-N-allyl-N-normorphine

CAS 2748-74-5

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Conditions: Synonyms or related compounds: Diacetylnalorphine

Source:Hotlist prohibited entry 348 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

O -Alkyldithiocarbonic acids, salts of

Canada Hotlist: O -Alkyldithiocarbonic acids, salts of

CAS 140-93-2; 140-92-1; 1000-90-4

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 349 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30

Octamoxin and its salts

Canada Hotlist: Octamoxin and its salts

CAS 4684-87-1

Health Canada lists this ingredient as prohibited for use in cosmetic products.

Source:Hotlist prohibited entry 350 · version Health Canada Hotlist 2025-08-13 · source checked 2026-08-30