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Nitrosamines

Canada Hotlist: Nitrosamines

Health Canada lists this ingredient as prohibited for use in cosmetic products.

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Regulatory decision and full conditions

Status
Prohibited
Legal role
Official guidance
Regulatory summary
Health Canada lists this ingredient as prohibited for use in cosmetic products.
Conditions and restrictions
Synonyms or related compounds: N-nitrosodiethanolamine

Substance identity

Official source name
Nitrosamines
CAS
64091-91-4; 35576-91-1; 930-55-2; 100-75-4; 10595-95-6; 59-89-2; 621-64-7; 924-16-3; 55-18-5; 1116-54-7; 62-75-9
EC
Not supplied in this source row
Identity mapping
standalone:cas_number
Search this identity across the siteCAS 64091-91-4CAS 35576-91-1CAS 930-55-2CAS 100-75-4CAS 10595-95-6CAS 59-89-2CAS 621-64-7CAS 924-16-3CAS 55-18-5CAS 1116-54-7CAS 62-75-9

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 100-75-4
CAS 100-75-4PubChem CID 7526

Verified chemistry for CAS 100-75-4

N-Nitrosopiperidine

IUPAC name
1-nitrosopiperidine
Molecular formula
C5H10N2O
Molecular weight
114.15 g/mol
Exact mass
114.079312947 Da
Monoisotopic mass
114.079312947 Da
XLogP3
0.4
Topological polar surface area
32.7 Ų
Molecular complexity
78.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
0
Heavy atoms
8
Covalent units
1

Names and synonyms reported to PubChem

Piperidine, 1-nitroso-NO-PipNPIPNitrosopiperidinN-Nitroso-piperidinnitrosopiperidineN-N-PipN-PIP
16 more reported names
TL 2666N066XUL4LNSC-138NSC138CHEBI:76324N-nitrosopentamethyleneimineRefChem:164027Hexahydro-N-nitroso-pyridine202-886-6RCRA waste number U179Pyridine, hexahydro-N-nitroso-1-Nitroso-piperidineNSC 138Nitrosopiperidin [German]CCRIS 477N-Nitroso-piperidin [German]
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
1
3D rings
1
3D hydrophobes
0
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
2.2
Machine-readable structure identifiers
SMILES
C1CCN(CC1)N=O
InChI
InChI=1S/C5H10N2O/c8-6-7-4-2-1-3-5-7/h1-5H2
InChIKey
UWSDONTXWQOZFN-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:76324

N-nitrosopiperidine

A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite.

Formula
C5H10N2O
Average mass
114.148 g/mol
Monoisotopic mass
114.07931 Da
Formal charge
0
  • nitrosamine — is a (CHEBI:35803)
  • piperidine — is a (CHEBI:18049)
  • carcinogenic agent — has role (CHEBI:50903)
  • apoptosis inducer — has role (CHEBI:68495)
  • mutagen — has role (CHEBI:25435)
  • environmental contaminant — has role (CHEBI:78298)
  • carcinogenic agent — has role (CHEBI:50903)
  • apoptosis inducer — has role (CHEBI:68495)
  • mutagen — has role (CHEBI:25435)
  • environmental contaminant — has role (CHEBI:78298)
  • nitrosamine — is a (CHEBI:35803)
  • piperidine — is a (CHEBI:18049)
Additional curated names
1-nitrosopiperidineN-nitrosohexahydropyridineNO-Pip
Cross-references from this source
  • CAS: 100-75-4 — ChemIDplus
  • CAS: 100-75-4 — NIST Chemistry WebBook
  • CAS: 100-75-4 — KEGG COMPOUND
  • REGISTRY_NUMBER: 110253 — Reaxys
  • MANUAL_X_REF: C19284 — KEGG COMPOUND

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2014-07-28. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7526

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 2% (1 of 51) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301 (98%): Toxic if swallowed [Danger Acute toxicity, oral]; H351 (92.2%): Suspected of causing cancer [Warning Carcinogenicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 51 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 51 reports by companies.; There are 4 notifications provided by 50 of 51 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H351: Suspected of causing cancer [Warning Carcinogenicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for N-nitrosopiperidine(SRC), using a log Kow of 0.36(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a structure estimation method(2), indicates that N-nitrosopiperidine is expected to have moderate mobility in soil(SRC). Volatilization of N-nitrosopiperidine from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 8.44X10-7 atm-cu m/mole(3). N-Nitrosopiperidine is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 9.20X10-2 mm Hg at 20 °C(4). A 33% biodegradation in 30 days(5) suggests that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a structure estimation method(2), indicates that N-nitrosopiperidine is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 8.44X10-7 atm-cu m/mole(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.36(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Under conditions simulating Southern California midsummer, midday sun, N-nitrosopiperidine exhibited an aqueous photolysis half-life of 12 minutes(7). A 33% biodegradation in 30 days(8) suggests that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N-nitrosopiperidine, which has a vapor pressure of 9.20X10-2 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase N-nitrosopiperidine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 hours(SRC), calculated from its rate constant of 2.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). N-Nitrosopiperidine has a UV absorption maximum of 337 nm in water(4), and therefore may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 10595-95-6
CAS 10595-95-6PubChem CID 25418

Verified chemistry for CAS 10595-95-6

N-Nitrosomethylethylamine

IUPAC name
N-ethyl-N-methylnitrous amide
Molecular formula
C3H8N2O
Molecular weight
88.11 g/mol
Exact mass
88.063662883 Da
Monoisotopic mass
88.063662883 Da
XLogP3
0.6
Topological polar surface area
32.7 Ų
Molecular complexity
46.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
1
Heavy atoms
6
Covalent units
1

Names and synonyms reported to PubChem

N-NitrosoethylmethylamineN-Methyl-N-nitrosoethanamineEthylmethylnitrosamineN-Nitroso-N-methylethylamineMethylethylnitrosamineMethylethylnitrosoamineN-Methyl-N-nitrosoethylamineNitrosoethylmethylamine
16 more reported names
Ethanamine, N-methyl-N-nitroso-Ethylamine, N-methyl-N-nitroso-N,N-MethylethylnitrosamineMethylaethylnitrosaminNitrosomethylethylamine00RLM29Y3AethylnitrosomethylamineRefChem:830860NMEAN-Ethyl-N-methylnitrosamineN-ethyl-N-methyl-nitrous amideethyl(methyl)nitrosoamineN-Nitroso-methyl ethylamineN-methyl-N-nitroso-ethanamineN-nitroso-methyl-ethylamineCCRIS 3058
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
0
3D rings
0
3D hydrophobes
0
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
2.0
Machine-readable structure identifiers
SMILES
CCN(C)N=O
InChI
InChI=1S/C3H8N2O/c1-3-5(2)4-6/h3H2,1-2H3
InChIKey
RTDCJKARQCRONF-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:82360

N-Nitrosomethylethylamine

Formula
C3H8N2O
Average mass
88.110 g/mol
Monoisotopic mass
88.06366 Da
Formal charge
0
  • nitroso compound — is a (CHEBI:35800)
  • nitroso compound — is a (CHEBI:35800)
Cross-references from this source
  • CAS: 10595-95-6 — KEGG COMPOUND
  • MANUAL_X_REF: C19281 — KEGG COMPOUND

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match25418

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 5.9% (3 of 51) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301 (94.1%): Toxic if swallowed [Danger Acute toxicity, oral]; H315 (78.4%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (78.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (78.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H351 (94.1%): Suspected of causing cancer [Warning Carcinogenicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 51 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 3 of 51 reports by companies.; There are 6 notifications provided by 48 of 51 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H351: Suspected of causing cancer [Warning Carcinogenicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for N-nitrosomethylethylamine(SRC), using a log Kow of 0.04(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 43(SRC), determined from a structure estimation method(2), indicates that N-nitrosomethylethylamine is expected to have very high mobility in soil(SRC). Volatilization of N-nitrosomethylethylamine from moist soil surfaces may be an important fate process(SRC) given an estimated Henry's Law constant of 1.44X10-6 atm-cu m/mole(SRC), using a fragment constant estimation method(2). N-Nitrosomethylethylamine is expected to volatilize from dry soil surfaces(SRC) based upon a an estimated vapor pressure of 1.1 mm Hg at 20 °C(3). Nitrosamines (such as N-nitrosomethylethylamine) photolyze rapidly in aqueous solution(4,5); therefore, photolysis is expected to occur on soil surfaces exposed to sunlight(SRC). N-Nitrosomethylethylamine has been shown to biodegrade slowly in anaerobic tests using digester sludge inocula(6). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 43(SRC), determined from a structure estimation method(2), indicates that N-nitrosomethylethylamine is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected at occur slowly(3) based upon an estimated Henry's Law constant of 1.44X10-6 atm-cu m/mole at 25 °C(SRC), developed using a fragment constant estimation method(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 24 and 177 days, respectively(SRC). According to a classification scheme(4), an estimated BCF of 3(SRC), from its log Kow of 0.04(5) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Nitrosamines (such as N-nitrosomethylethylamine) photolyze rapidly in aqueous solution(6); at a solar zenith angle of 40 deg N, the photolysis half-life of N-nitrosomethylethylamine and similar nitrosamines at the water's surface (exposed to full sunlight) is about 5.8 min(6). The direct photolysis rate constant for N-nitrosomethylethylamine in aqueous solution exposed to Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N-nitrosomethylethylamine, which has an estimated vapor pressure of 1.1 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase N-nitrosomethylethylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.6 days(SRC), calculated from its rate constant of 1.0X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Vapor-phase N-nitrosomethylethylamine may degrade readily via direct photolysis(SRC) based on rapid degradation in aqueous solution which has estimated half-lives of 5.8 minutes at a solar zenith angle of 40 deg N(4) and 15 minutes under California midsummer, midday sun irradiation(5). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 1116-54-7
CAS 1116-54-7PubChem CID 14223

Verified chemistry for CAS 1116-54-7

N-Nitrosodiethanolamine

IUPAC name
N,N-bis(2-hydroxyethyl)nitrous amide
Molecular formula
C4H10N2O3
Molecular weight
134.13 g/mol
Exact mass
134.06914219 Da
Monoisotopic mass
134.06914219 Da
XLogP3
-1.5
Topological polar surface area
73.1 Ų
Molecular complexity
72.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
5
Rotatable bonds
4
Heavy atoms
9
Covalent units
1

Names and synonyms reported to PubChem

NdelaDiethanolnitrosamineNitrosodiethanolamine2,2'-(Nitrosoimino)bisethanolDiethanolnitrosoamineN,N-DiethanolnitrosamineNitrosoimino diethanolN-Nitrosoaminodiethanol
16 more reported names
NCI-C55583DiaethanolnitrosaminEthanol, N-nitrosoiminodi-N-NitrosodiaethanolaminEthanol, 2,2'-(nitrosoimino)bis-2,2'-Iminodi-N-nitrosoethanolEthanol, 2,2'-nitrosiminodi-N-Nitrosobis(2-hydroxyethyl)amineBis(beta-hydroxyethyl)nitrosamineDiethylamine, 2,2'-dihydroxy-N-nitroso-2,2'-nitrosiminodiethanolBis(beta-hydroxyaethyl)nitrosamin30YI1289VYDI-(2-HYDROXYETHYL)NITROSAMINEN-nitrosoiminodiethanolRefChem:830844
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
0
3D hydrophobes
0
3D acceptor features
2
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
5.0
Machine-readable structure identifiers
SMILES
C(CO)N(CCO)N=O
InChI
InChI=1S/C4H10N2O3/c7-3-1-6(5-9)2-4-8/h7-8H,1-4H2
InChIKey
YFCDLVPYFMHRQZ-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match14223

Attributed physical-property, hazard, environmental and use annotations.

  • Solubility: greater than or equal to 100 mg/mL at 68.9 °F (NTP, 1992) Source: CAMEO Chemicals
  • Solubility: Miscible with water in all proportions; soluble in polar organic solvents; insoluble in non-polar organic solvents Source: Hazardous Substances Data Bank (HSDB)
  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H225 (30.1%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H350 (100%): May cause cancer [Danger Carcinogenicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P318, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 133 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for N-nitrosodiethanolamine(SRC), using an estimated log Kow of -1.28(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that N-nitrosodiethanolamine is expected to have very high mobility in soil(SRC). Volatilization of N-nitrosodiethanolamine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.9X10-12 atm-cu m/mole(SRC), using a fragment constant estimation method(2). N-Nitrosodiethanolamine is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 5.0X10-4 mm Hg at 20 °C(3). N-Nitrosodiethanolamine has a UV absorption max at 345 nm(4) which indicates that the compound may be susceptible to direct photolysis by sunlight(SRC). Biodegradation in soil may be slow(SRC), based upon N-nitrosodiethanolamine's slow biodegradation in two lake waters and sewage(5). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that N-nitrosodiethanolamine is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 4.9X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). According to a classification scheme(4), an estimated BCF of 3(SRC), from an estimated log Kow of -1.28(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low. The direct photolysis rate constant for the analogous compound N-nitrosodiethylamine in aqueous solution exposed to irradiation representing Southern California midsummer, midday sun was observed to be 0.045/min with a half-life of 15 minutes and a quantum yield of 0.43(5); the photolysis rate of N-Nitrosodiethanolamine is expected to be similar(SRC). N-Nitrosodiethanolamine biodegraded slowly in samples of sewage and two lake waters(6). The fastest degradation of N-nitrosodiethanolamine in a lake water sample was in one taken in August; an initia Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N-nitrosodiethanolamine, which has an estimated vapor pressure of 5.0X10-4 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase N-nitrosodiethanolamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 13 hours(SRC), calculated from its rate constant of 3X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). N-Nitrosodiethanolamine has a UV absorption max at 345 nm(4) which indicates that N-Nitrosodiethanolamine may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 35576-91-1
CAS 35576-91-1PubChem CID 37183

Verified chemistry for CAS 35576-91-1

Nitrosamine

IUPAC name
nitrous amide
Molecular formula
H2N2O
Molecular weight
46.029 g/mol
Exact mass
46.016712692 Da
Monoisotopic mass
46.016712692 Da
XLogP3
-0.6
Topological polar surface area
55.5 Ų
Molecular complexity
10.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Rotatable bonds
0
Heavy atoms
3
Covalent units
1

Names and synonyms reported to PubChem

NitrosamideN-NITROSAMINELGB75A6POHNSC-223080RefChem:166119CHEBI:35803hydroxydiazeneHYDROXYDIIMIDE
9 more reported names
NITROXYLAMIDEketohydrazineHydroxydiiminediazene-N-oxideNSC 223080UNII-LGB75A6POHNITROSAMINE-(H2N-N=O)NITROSAMINE (H2N-N=0)XKLJHFLUAHKGGU-UHFFFAOYSA-N
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
0
3D rings
0
3D hydrophobes
0
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
0.0
Machine-readable structure identifiers
SMILES
NN=O
InChI
InChI=1S/H2N2O/c1-2-3/h(H2,1,3)
InChIKey
XKLJHFLUAHKGGU-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 55-18-5
CAS 55-18-5PubChem CID 5921

Verified chemistry for CAS 55-18-5

N-Nitrosodiethylamine

IUPAC name
N,N-diethylnitrous amide
Molecular formula
C4H10N2O
Molecular weight
102.14 g/mol
Exact mass
102.079312947 Da
Monoisotopic mass
102.079312947 Da
XLogP3
0.5
Topological polar surface area
32.7 Ų
Molecular complexity
51.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
2
Heavy atoms
7
Covalent units
1

Names and synonyms reported to PubChem

DiethylnitrosamineNDEADiethylnitrosoamineN-Ethyl-N-nitrosoethanamineN,N-DiethylnitrosoamineNitrosodiethylamineN,N-DiethylnitrosamineDiethylnitrosamide
16 more reported names
DENAEthanamine, N-ethyl-N-nitroso-Diethylamine, N-nitroso-N-Nitroso-N,N-diethylamineDiaethylnitrosaminDEN (mutagen)N-Nitroso-diaethylamineN-Ethyl-N-nitroso-ethanamine3IQ78TTX1ANSC-132NSC132CHEBI:34873nitrous diethylamideN NitrosodiethylamineRefChem:388928200-226-1
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
0
3D rings
0
3D hydrophobes
0
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
CCN(CC)N=O
InChI
InChI=1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
InChIKey
WBNQDOYYEUMPFS-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 59-89-2
CAS 59-89-2PubChem CID 6046

Verified chemistry for CAS 59-89-2

N-Nitrosomorpholine

IUPAC name
4-nitrosomorpholine
Molecular formula
C4H8N2O2
Molecular weight
116.12 g/mol
Exact mass
116.058577502 Da
Monoisotopic mass
116.058577502 Da
XLogP3
-0.4
Topological polar surface area
41.9 Ų
Molecular complexity
80.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
0
Heavy atoms
8
Covalent units
1

Names and synonyms reported to PubChem

NitrosomorpholineMorpholine, 4-nitroso-NMORN-NitrosomorpholinMorpholine, N-nitroso-NCI-C021643L25FO7FN7CHEBI:76326
16 more reported names
NSC-139NSC139RefChem:164021627-564-6N-Nitrosomorfolin4-Nitroso-morpholineBRN 01121394-Nitrosomorpholine 1.0 mg/ml in MethanolN0466EN300-7323775Nitrosomorpholine; 4-Nitrosomorpholine; NSC 139NSC 139N-Nitrosomorfolin [Czech]CAS-59-89-2N-Nitrosomorpholin [German]CCRIS 473
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
2
3D rings
1
3D hydrophobes
0
3D acceptor features
1
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
2.2
Machine-readable structure identifiers
SMILES
C1COCCN1N=O
InChI
InChI=1S/C4H8N2O2/c7-5-6-1-3-8-4-2-6/h1-4H2
InChIKey
ZKXDGKXYMTYWTB-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 62-75-9
CAS 62-75-9PubChem CID 6124

Verified chemistry for CAS 62-75-9

N-Nitrosodimethylamine

N-nitrosodimethylamine is a nitrosamine. It has a role as a geroprotector and a mutagen. — ChEBI

IUPAC name
N,N-dimethylnitrous amide
Molecular formula
C2H6N2O
Molecular weight
74.08 g/mol
Exact mass
74.048012819 Da
Monoisotopic mass
74.048012819 Da
XLogP3
-0.6
Topological polar surface area
32.7 Ų
Molecular complexity
34.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
0
Heavy atoms
5
Covalent units
1

Names and synonyms reported to PubChem

DimethylnitrosamineNDMAN-Methyl-N-nitrosomethanamineDimethylnitrosoamineNitrosodimethylamineN,N-DimethylnitrosamineDMNAMethanamine, N-methyl-N-nitroso-
16 more reported names
Dimethylnitrosamindimethyl(nitroso)amineN-Nitroso-N,N-dimethylamineDimethylamine, N-nitroso-N-NitroaodimethylamineN-Dimethyl-nitrosaminenitrous dimethylamideRCRA waste number P082N-methyl-N-nitroso-methanamineN NitrosodimethylamineNDMA NitrosodimethylamineNitrosodimethylamine, NDMA1,1-Dimethyl-2-oxohydrazineM43H21IO8RNSC-23226CHEBI:35807
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
0
3D rings
0
3D hydrophobes
0
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
3
Effective 3D rotors
1.0
Machine-readable structure identifiers
SMILES
CN(C)N=O
InChI
InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3
InChIKey
UMFJAHHVKNCGLG-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 621-64-7
CAS 621-64-7PubChem CID 12130

Verified chemistry for CAS 621-64-7

N-Nitrosodipropylamine

N-Nitrosodi-n-propylamine is a nitroso compound. — ChEBI

IUPAC name
N,N-dipropylnitrous amide
Molecular formula
C6H14N2O
Molecular weight
130.19 g/mol
Exact mass
130.110613074 Da
Monoisotopic mass
130.110613074 Da
XLogP3
1.4
Topological polar surface area
32.7 Ų
Molecular complexity
69.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
4
Heavy atoms
9
Covalent units
1

Names and synonyms reported to PubChem

N-NITROSODI-N-PROPYLAMINEDipropylnitrosamineN,N-DipropylnitrosamineNitrosodipropylamineDi-n-propylnitrosamine1-Propanamine, N-nitroso-N-propyl-N-Nitroso-N-propyl-1-propanamineDipropylamine, N-nitroso-
16 more reported names
NDPADi-n-propylnitrosoaminePropylamine, N-nitroso-N-di-DPNAPropanamine, N-nitroso-N-propyl-N-Nitroso(di-n-propyl)amineN,N-Di-n-propylnitrosamineN-Nitroso-N-di-n-propylamineNSC-1332920IH58NCNSC133nitrous dipropylamideN-nitroso-N-dipropylamineRefChem:163988210-698-0RCRA waste number U111
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
2
3D rings
0
3D hydrophobes
2
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
5.0
Machine-readable structure identifiers
SMILES
CCCN(CCC)N=O
InChI
InChI=1S/C6H14N2O/c1-3-5-8(7-9)6-4-2/h3-6H2,1-2H3
InChIKey
YLKFDHTUAUWZPQ-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 64091-91-4
CAS 64091-91-4PubChem CID 47289

Verified chemistry for CAS 64091-91-4

4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone

IUPAC name
N-methyl-N-(4-oxo-4-pyridin-3-ylbutyl)nitrous amide
Molecular formula
C10H13N3O2
Molecular weight
207.23 g/mol
Exact mass
207.100776666 Da
Monoisotopic mass
207.100776666 Da
XLogP3
0.8
Topological polar surface area
62.6 Ų
Molecular complexity
221.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Rotatable bonds
5
Heavy atoms
15
Covalent units
1

Names and synonyms reported to PubChem

4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-oneCHEBI:326927S395EDO614-[methyl(nitroso)amino]-1-(pyridin-3-yl)butan-1-one4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanoneNicotine-derived nitrosamine ketone
16 more reported names
4-Methylnitrosamino-1,3-pyridyl-1-butanone4-n-nitrosomethylamino-1-3-pyridyl-1-butanoneNNK cpd4-(methyl(nitroso)amino)-1-(pyridin-3-yl)butan-1-oneRefChem:259414'-(nitrosomethylamino)-1-(3-pyridyl)-1-butanoneNNKNNK (carcinogen)1-Butanone, 4-(methylnitrosoamino)-1-(3-pyridinyl)-4-(N-Nitroso-N-methylamino)-1-(3-pyridyl)-1-butanoneN-methyl-N-(4-oxo-4-(pyridin-3-yl)butyl)nitrous amideN-Methyl-N-[4-oxo-4-(pyridin-3-yl)butyl]nitrous amide4-Methylnitrosoamino-1-(3-pyridinyl)-1-butanoneN-Nitrosonornicotine-ketone4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanoneN-Methyl-N-nitroso-4-oxo-4-(3-pyridyl)butyl amine
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
1
3D hydrophobes
0
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
6.0
Machine-readable structure identifiers
SMILES
CN(CCCC(=O)C1=CN=CC=C1)N=O
InChI
InChI=1S/C10H13N3O2/c1-13(12-15)7-3-5-10(14)9-4-2-6-11-8-9/h2,4,6,8H,3,5,7H2,1H3
InChIKey
FLAQQSHRLBFIEZ-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 924-16-3
CAS 924-16-3PubChem CID 13542

Verified chemistry for CAS 924-16-3

N-Nitrosodibutylamine

IUPAC name
N,N-dibutylnitrous amide
Molecular formula
C8H18N2O
Molecular weight
158.24 g/mol
Exact mass
158.141913202 Da
Monoisotopic mass
158.141913202 Da
XLogP3
2.6
Topological polar surface area
32.7 Ų
Molecular complexity
88.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
6
Heavy atoms
11
Covalent units
1

Names and synonyms reported to PubChem

DibutylnitrosamineNitrosodibutylamineNDBAN-NITROSODI-N-BUTYLAMINEN,N-DibutylnitrosoamineDibutylnitrosoamineN-Butyl-N-nitroso-1-butanamineDBNA
16 more reported names
Dibutylamine, N-nitroso-N,N-Di-n-butylnitrosamineN,N-DibutylnitrosamineButylamine, N-nitrosodi-Di-N-butylnitrosaminDi-n-butylnitrosamineN-Butyl-N-nitroso-1-butamineNSC-68308K8942WN31NSC6830RefChem:163991213-101-1N-Nitroso-di-n-butylamine1-Butanamine, N-butyl-N-nitroso-NSC 6830N-Butyl-N-nitroso-1-butaneamine
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
2
3D rings
0
3D hydrophobes
2
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
7.0
Machine-readable structure identifiers
SMILES
CCCCN(CCCC)N=O
InChI
InChI=1S/C8H18N2O/c1-3-5-7-10(9-11)8-6-4-2/h3-8H2,1-2H3
InChIKey
YGJHZCLPZAZIHH-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 930-55-2
CAS 930-55-2PubChem CID 13591

Verified chemistry for CAS 930-55-2

N-Nitrosopyrrolidine

IUPAC name
1-nitrosopyrrolidine
Molecular formula
C4H8N2O
Molecular weight
100.12 g/mol
Exact mass
100.063662883 Da
Monoisotopic mass
100.063662883 Da
XLogP3
-0.2
Topological polar surface area
32.7 Ų
Molecular complexity
68.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
0
Heavy atoms
7
Covalent units
1

Names and synonyms reported to PubChem

Pyrrolidine, 1-nitroso-NPYRNo-pyrNitrosopyrrolidineN-Nitrosopyrrolidin1-Pyrrolidinamine, N-nitroso-N-PYRPyrrole, tetrahydro-N-nitroso-
16 more reported names
SZ4J5WK201NSC-18797Tetrahydro-N-nitroso-PyrroleN-N-PYRN NitrosopyrrolidineRefChem:389135213-218-8N-Nitroso-pyrrolidine1-nitroso-PyrrolidineNSC 18797N-Nitrosopyrrolidine (NPYR)RCRA waste number U180CAS-930-55-2N-Nitrosopyrrolidin [German]CCRIS 478Pyrrolidine, nitroso-
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
1
3D rings
1
3D hydrophobes
0
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
6
Effective 3D rotors
2.0
Machine-readable structure identifiers
SMILES
C1CCN(C1)N=O
InChI
InChI=1S/C4H8N2O/c7-5-6-3-1-2-4-6/h1-4H2
InChIKey
WNYADZVDBIBLJJ-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Health Canada Cosmetic Ingredient Hotlist
Source reference
Hotlist prohibited entry 343
Source record ID
prohibited:343
Source version
Health Canada Hotlist 2025-08-13
Source language
English
Translation status
Original is English
Source updated
2025-08-13
Snapshot checked
2026-08-30 04:07 UTC
Validation method
strict HTML tables t1=490 and t2=90
SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a

Registered dataset notes

Dataset coverage
Administrative prohibitions, restrictions, conditions and warning requirements
Authority note
Official Health Canada compliance indicator; not a complete safety clearance
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

580
current Canada records
490
records marked Prohibited
580
records from this source version
516
market records with CAS identity

Status distribution

Prohibited: 490Restricted: 90

Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Canada market context

Complete Hotlist snapshot

Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025

All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.

Verification checklist

  1. Search English/French names and CAS identifiers.
  2. Apply every restriction, concentration and label warning.
  3. Check Food and Drugs Act/Cosmetic Regulations requirements.
  4. Recheck the current Hotlist before notification or sale.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Nitrosamines” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search English/French names and CAS identifiers.
  3. Apply every restriction, concentration and label warning.
  4. Check Food and Drugs Act/Cosmetic Regulations requirements.
  5. Recheck the current Hotlist before notification or sale.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

The record cites Hotlist prohibited entry 343, source version Health Canada Hotlist 2025-08-13. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Nitrosamines. Hotlist prohibited entry 343. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/343/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Canada

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The authority uses this source as compliance guidance; the underlying legislation remains controlling.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Official guidance
  • Source version: Health Canada Hotlist 2025-08-13

What it does not prove

The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

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FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

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ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

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Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

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NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

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