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Annex V Entry 50 16/10/2010

chlorphenesin

3-(p-Chlorophenoxy)-propane-1,2-diol

chlorphenesin appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: 0.3%.

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Permitted preservative— Annex V, EU Regulation 1223/2009
Max conc.: 0.3%
Entry: 50

Chemical identity and properties

PubChem 2D chemical structure for CAS 104-29-0
CAS 104-29-0PubChem CID 7697

Chlorphenesin

Chlorphenesin is glycerol in which the hydrogen of one of the primary hydroxy groups is substituted by a 4-chlorophenyl group. It has antifungal and antibacterial properties, and is used for treatment of cutaneous and vaginal infections. Its 1-carbamate is used as a skeletal muscle relaxant for the treatment of painful muscle spasm. It has a role as an antibacterial drug, a muscle relaxant and an antifungal drug. It is a glycol, a member of propane-1,2-diols and a member of monochlorobenzenes. — ChEBI

IUPAC name
3-(4-chlorophenoxy)propane-1,2-diol
Molecular formula
C9H11ClO3
Molecular weight
202.63 g/mol
Exact mass
202.0396719 Da
XLogP3
1.2
Topological polar surface area
49.7 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

3-(4-Chlorophenoxy)-1,2-propanediolChlorphenesinumChlorphenesineClorfenesina1,2-Propanediol, 3-(4-chlorophenoxy)-3-(p-Chlorophenoxy)-1,2-propanediolGlycerol alpha-p-chlorophenyl etherp-Chlorophenyl-alpha-glyceryl ether
16 more reported names
3-(p-Chlorophenoxy)propane-1,2-diolI670DAL4SZCHEBI:3642RefChem:57031203-192-6ChlorophenesinGecophenDemykonp-Chlorophenyl glyceryl etherC9H11ClO3Clorfenesina [INN-Spanish]Chlorphenesine [INN-French]Chlorphenesinum [INN-Latin]NSC 6401Maybridge1_0001701,2-PROPANEDIOL, 3-(p-CHLOROPHENOXY)-
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:3642

chlorphenesin

Glycerol in which the hydrogen of one of the primary hydroxy groups is substituted by a 4-chlorophenyl group. It has antifungal and antibacterial properties, and is used for treatment of cutaneous and vaginal infections. Its 1-carbamate is used as a skeletal muscle relaxant for the treatment of painful muscle spasm.

Formula
C9H11ClO3
Average mass
202.637 g/mol
Monoisotopic mass
202.03967 Da
Formal charge
0
  • monochlorobenzenes — is a (CHEBI:83403)
  • glycol — is a (CHEBI:13643)
  • propane-1,2-diols — is a (CHEBI:26284)
  • antifungal drug — has role (CHEBI:86327)
  • muscle relaxant — has role (CHEBI:51371)
  • antibacterial drug — has role (CHEBI:36047)
  • antifungal drug — has role (CHEBI:86327)
  • muscle relaxant — has role (CHEBI:51371)
  • antibacterial drug — has role (CHEBI:36047)
  • monochlorobenzenes — is a (CHEBI:83403)
  • glycol — is a (CHEBI:13643)
  • propane-1,2-diols — is a (CHEBI:26284)
Additional curated names
3-(4-chlorophenoxy)propane-1,2-diol3-(4-chlorophenoxy)-1,2-propanediol3-(p-chlorophenoxy)-1,2-propanediol3-(p-chlorophenoxy)propane-1,2-diolchlorphenesinChlorphenesinp-chlorophenyl-alpha-glyceryl etherglycerol alpha-p-chlorophenyl ether
Cross-references from this source
  • CAS: 104-29-0 — ChemIDplus
  • CAS: 104-29-0 — KEGG COMPOUND
  • REGISTRY_NUMBER: 2210845 — Reaxys
  • MANUAL_X_REF: C07928 — KEGG COMPOUND
  • MANUAL_X_REF: Chlorphenesin — Wikipedia
  • MANUAL_X_REF: DB00856 — DrugBank
  • MANUAL_X_REF: GB628497 — Patent
  • MANUAL_X_REF: US2468423 — Patent

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2015-07-09. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7697

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (30.6%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (84.1%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (13.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (69.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (10.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (35.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 353 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

0.3%

INCI glossary name

chlorphenesin

Chemical name

3-(p-Chlorophenoxy)-propane-1,2-diol

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

Key data

CAS
104-29-0
EC
203-192-6
Annex
V
Entry number
50

Inventory links for chlorphenesin

Inventory Restriction reference
Ref 32667

CHLORPHENESIN

CAS: 104-29-0
EC: 203-192-6

Direct matches are limited for this record, so nearby entries from Annex V are shown as well.

Annex V 48
Nearby record in the same annex

GLUTARAL

CAS: 111-30-8
EC: 203-856-5
Annex V 52
Nearby record in the same annex

SILVER CHLORIDE

CAS: 7783-90-6
EC: 232-033-3

What Annex V means for chlorphenesin

chlorphenesin is an approved preservative listed in Annex V of EU Cosmetics Regulation 1223/2009. Only substances on this positive list may be used as cosmetic preservatives in the EU.

Each preservative entry specifies maximum permitted concentrations and applicable product scope. Concentrations must not exceed the listed maximum. Some preservatives require warning statements on the product label.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Use concentration must not exceed: 0.3%
  • Verify the preservative is effective at the permitted concentration for your matrix.

Frequently asked questions

Yes. chlorphenesin is listed in Annex V of EU Cosmetics Regulation 1223/2009 as a permitted preservative. It may be used in cosmetics up to the maximum concentration specified above, within the permitted product scope.

CAS 104-29-0 is the unique numerical identifier assigned to chlorphenesin by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 0.3% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex V record chlorphenesin

This page summarizes one Annex V record for chlorphenesin from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex V conditions for chlorphenesin, but confirm any final regulatory decision against the current official annex wording and source files.

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