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Annex V Entry 47 25/10/2010

HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN

Benzenecarboximidamide, 4,4'-(1,6-hexanediylbis(oxy))bis-, and its salts (including isothionate and p-hydroxybenzoate)

HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: 0.1%.

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Permitted preservative— Annex V, EU Regulation 1223/2009
Max conc.: 0.1%
Entry: 47

Chemical identity and properties

PubChem 2D chemical structure for CAS 3811-75-4
CAS 3811-75-4PubChem CID 65130

Hexamidine

Hexamidine is a polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol. It has a role as an antimicrobial agent and an antiseptic drug. It is a member of guanidines, an aromatic ether and a polyether. It is functionally related to a hexane-1,6-diol. — ChEBI

IUPAC name
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide
Molecular formula
C20H26N4O2
Molecular weight
354.4 g/mol
Exact mass
354.20557608 Da
XLogP3
2.9
Topological polar surface area
118.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

HexamidinaHexamidinum4,4'-(1,6-Hexanediylbis(oxy))bis-benzenecarboximidamide3483C2H13HCHEBI:87184Benzenecarboximidamide, 4,4'-(1,6-hexanediylbis(oxy))bis-1,6-di(para-amidinophenoxy)hexane4-{[6-(4-carbamimidoylphenoxy)hexyl]oxy}benzene-1-carboximidamide
16 more reported names
4-((6-(4-carbamimidoylphenoxy)hexyl)oxy)benzene-1-carboximidamide1,6-di-(4-amidinophenoxy)hexaneRefChem:786246D08AC04R01AX07R02AA18S01AX08S03AA054,4'[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE4,4'-[hexane-1,6-diylbis(oxy)]di(benzene-1-carboximidamide)Hexamidinum [INN-Latin]Hexamidina [INN-Spanish]Hexamidine [INN:BAN:DCF]UNII-3483C2H13HHEXAMIDINE [MI]Hexamidine (INN/BAN)
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 659-40-5
CAS 659-40-5PubChem CID 3080571

Hexamidine Diisethionate

Hexamidine and Hexamidine Diisethionate are safe for the use in cosmetic products in the practices and concentrations of use as described in this safety assessment if used at concentrations less than or equal to 0.10%. — Cosmetic Ingredient Review (CIR)

IUPAC name
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;bis(2-hydroxyethanesulfonic acid)
Molecular formula
C24H38N4O10S2
Molecular weight
606.7 g/mol
Exact mass
606.20293577 Da
Topological polar surface area
284.0 Ų
Hydrogen-bond donors
8
Hydrogen-bond acceptors
12
Covalent units
3
Defined stereocentres
0

Also known as

Hexamidine isethionatehexomedinhexamidine isetionate023XA5Z50LNSC-115848RF-2535Laryngomedin NHexomedin N
16 more reported names
RefChem:146090211-533-5DesomedineHexamidine diisetionate4,4'-(Hexane-1,6-diylbis(oxy))dibenzimidamide bis(2-hydroxyethanesulfonate)HexomedineOphtamedineEsomedina2-HYDROXYETHANESULPHONIC ACID, COMPOUND WITH 4,4'-[HEXANE-1,6-DIYLBIS(OXY)]BIS[BENZENECARBOXAMIDINE] (2:1)2535 RPRP 25354-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid2-hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (22535 R. P.DesmedineUNII-023XA5Z50L
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Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 93841-83-9
CAS 93841-83-9PubChem CID 46235485

p-Hydroxybenzoic acid, compound with p,p'-(hexane-1,6-diylbis(oxy))bis(benzamidine) (2:1)

IUPAC name
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;bis(4-hydroxybenzoic acid)
Molecular formula
C34H38N4O8
Molecular weight
630.7 g/mol
Exact mass
630.26896418 Da
Topological polar surface area
233.0 Ų
Hydrogen-bond donors
8
Hydrogen-bond acceptors
10
Covalent units
3
Defined stereocentres
0

Also known as

P-hydroxybenzoic acid, compound with p,p'-[hexane-1,6-diylbis(oxy)]bis(benzamidine) (2:1)RefChem:858083Hexamidine diparabenHEXAMIDINE PARABENUNII-XBD058OZ1MXBD058OZ1MEINECS 299-055-34-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;4-hydroxybenzoic acid
2 more reported names
4,4'-(hexane-1,6-diylbis(oxy))dibenzimidamide bis(4-hydroxybenzoate)BENZENECARBOXIMIDAMIDE, 4,4'-(1,6-HEXANEDIYLBIS(OXY))BIS-, BIS(4-HYDROXYBENZOATE)
Open full PubChem recordPubChem annotations3D structure image

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

0.1%

INCI glossary name

HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN

Chemical name

Benzenecarboximidamide, 4,4'-(1,6-hexanediylbis(oxy))bis-, and its salts (including isothionate and p-hydroxybenzoate)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
3811-75-4 / 659-40-5 / 93841-83-9 / -
EC
- / 211-533-5 / 299-055-3 / -
Annex
V
Entry number
47

Inventory links for HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN

Inventory Restriction reference
Ref 34259

HEXAMIDINE

CAS: 3811-75-4

Direct matches are limited for this record, so nearby entries from Annex V are shown as well.

Annex V 48
Nearby record in the same annex

GLUTARAL

CAS: 111-30-8
EC: 203-856-5
Annex V 50
Nearby record in the same annex

chlorphenesin

CAS: 104-29-0
EC: 203-192-6
Annex V 52
Nearby record in the same annex

SILVER CHLORIDE

CAS: 7783-90-6
EC: 232-033-3

What Annex V means for HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN

HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN is an approved preservative listed in Annex V of EU Cosmetics Regulation 1223/2009. Only substances on this positive list may be used as cosmetic preservatives in the EU.

Each preservative entry specifies maximum permitted concentrations and applicable product scope. Concentrations must not exceed the listed maximum. Some preservatives require warning statements on the product label.

This record is linked to 4 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Use concentration must not exceed: 0.1%
  • Verify the preservative is effective at the permitted concentration for your matrix.

Frequently asked questions

Yes. HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN is listed in Annex V of EU Cosmetics Regulation 1223/2009 as a permitted preservative. It may be used in cosmetics up to the maximum concentration specified above, within the permitted product scope.

CAS 3811-75-4 / 659-40-5 / 93841-83-9 / - is the unique numerical identifier assigned to HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 0.1% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex V record HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN

This page summarizes one Annex V record for HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex V conditions for HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN, but confirm any final regulatory decision against the current official annex wording and source files.

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