EU cosmetic ingredients, restrictions and safety

Annex V Entry 46 02/08/2021

DIAZOLIDINYL UREA

N-(Hydroxymethyl)-N-(dihydroxymethyl-1,3-dioxo-2,5-imidazolidinyl-4)-N'-(hydroxymethyl)urea

DIAZOLIDINYL UREA appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: 0.5%.

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Permitted preservative— Annex V, EU Regulation 1223/2009

Max conc.: 0.5%

Entry: 46

Record details

Maximum concentration

0.5%

INCI glossary name

DIAZOLIDINYL UREA

Chemical name

N-(Hydroxymethyl)-N-(dihydroxymethyl-1,3-dioxo-2,5-imidazolidinyl-4)-N'-(hydroxymethyl)urea

Chemical / IUPAC name

N-(Hydroxymethyl)-N-(dihydroxymethyl-1,3-dioxo-2,5-imidazolidinyl-4)-N'-(hydroxymethyl)urea

Regulatory information

Regulation

(EC) 2009/1223

SCCS opinions

Opinion on The Determination of certain Formaldehyde Releasers in Cosmetic Products
SCIENTIFIC ADVICE ON the threshold for the warning ‘contains formaldehyde’ in Annex V, preamble point 2 for formaldehyde-releasing substances

Identified ingredients

DIAZOLIDINYL UREA

Key data

CAS

EC

Annex

Entry number

46

Inventory links for DIAZOLIDINYL UREA

Inventory Restriction reference

Ref 33218

DIAZOLIDINYL UREA

CAS: 78491-02-8

EC: 278-928-2

Direct matches are limited for this record, so nearby entries from Annex V are shown as well.

Annex V 45

Nearby record in the same annex

DIMETHYL OXAZOLIDINE

CAS: 51200-87-4

EC: 257-048-2

Annex V 47

Nearby record in the same annex

HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN

CAS: 3811-75-4 / 659-40-5 / 93841-83-9 / -

EC: - / 211-533-5 / 299-055-3 / -

Annex V 44

Nearby record in the same annex

BEHENTRIMONIUM CHLORIDE (1) / CETRIMONIUM BROMIDE / CETRIMONIUM CHLORIDE (2)/ LAURTRIMONIUM BROMIDE…

CAS: 17301-53-0 / 57-09-0 / 112-02-7 / 1119-94-4 / 112-00-5 / 1120-02-1 / 112-03-8

EC: 241-327-0 / 200-311-3 / 203-928-6 / 214-290-3 / 203-927-0 / 214-294-5 / 203-929-1

Annex V 48

Nearby record in the same annex

GLUTARAL

CAS: 111-30-8

EC: 203-856-5

Annex V 43

Nearby record in the same annex

PHENOXYISOPROPANOL

CAS: 770-35-4

EC: 212-222-7

Annex V 49

Nearby record in the same annex

7-ETHYLBICYCLOOXAZOLIDINE

CAS: 7747-35-5

EC: 231-810-4

Annex V 42

Nearby record in the same annex

CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE

CAS: 55-56-1 / 56-95-1 / 18472-51-0 / 3697-42-5

EC: 200-238-7 / 200-302-4 / 242-354-0 / 223-026-6

Annex V 50

Nearby record in the same annex

chlorphenesin

CAS: 104-29-0

EC: 203-192-6

Annex V 39

Nearby record in the same annex

METHYLCHLOROISOTHIAZOLINONE AND METHYLISOTHIAZOLINONE

CAS: 26172-55-4, 2682-20-4, 55965-84-9

EC: 247-500-7, 220-239-6

Annex V 51

Nearby record in the same annex

SODIUM HYDROXYMETHYLGLYCINATE

CAS: 70161-44-3

EC: 274-357-8

Annex V 38

Nearby record in the same annex

O-CYMEN-5-OL

CAS: 3228-02-2

EC: 221-761-7

Annex V 52

Nearby record in the same annex

SILVER CHLORIDE

CAS: 7783-90-6

EC: 232-033-3

What Annex V means for DIAZOLIDINYL UREA

DIAZOLIDINYL UREA is an approved preservative listed in Annex V of EU Cosmetics Regulation 1223/2009. Only substances on this positive list may be used as cosmetic preservatives in the EU.

Each preservative entry specifies maximum permitted concentrations and applicable product scope. Concentrations must not exceed the listed maximum. Some preservatives require warning statements on the product label.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

Use concentration must not exceed: 0.5%
Verify the preservative is effective at the permitted concentration for your matrix.

Frequently asked questions

Yes. DIAZOLIDINYL UREA is listed in Annex V of EU Cosmetics Regulation 1223/2009 as a permitted preservative. It may be used in cosmetics up to the maximum concentration specified above, within the permitted product scope.

CAS 78491-02-8 is the unique numerical identifier assigned to DIAZOLIDINYL UREA by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 0.5% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

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Source note for Annex V record DIAZOLIDINYL UREA

This page summarizes one Annex V record for DIAZOLIDINYL UREA from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex V conditions for DIAZOLIDINYL UREA, but confirm any final regulatory decision against the current official annex wording and source files.

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