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Annex V Entry 49 02/08/2021

7-ETHYLBICYCLOOXAZOLIDINE

5-Ethyl-3,7-dioxa-1-azabicyclo[3.3.0] octane

7-ETHYLBICYCLOOXAZOLIDINE appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: 0.3%.

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Permitted preservative— Annex V, EU Regulation 1223/2009
Max conc.: 0.3%
Entry: 49

Chemical identity and properties

PubChem 2D chemical structure for CAS 7747-35-5
CAS 7747-35-5PubChem CID 82190

Oxazolidine-E

IUPAC name
7a-ethyl-1,3,5,7-tetrahydro-[1,3]oxazolo[3,4-c][1,3]oxazole
Molecular formula
C7H13NO2
Molecular weight
143.18 g/mol
Exact mass
143.094628657 Da
XLogP3
0.5
Topological polar surface area
21.7 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

Oxazolidine E7-Ethylbicyclooxazolidine5-Ethyl-1-aza-3,7-dioxabicyclo[3.3.0]octaneOxaban E7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazoleCCRIS 90077a-ethyldihydro-1h,3h,5h-oxazolo[3,4-c]oxazoleOXABAN-E
16 more reported names
TRUPTAN OX-EEINECS 231-810-41H,3H,5H-Oxazolo(3,4-c)oxazole, 7a-ethyldihydro-AMINE CS 1246EC 231-810-41-Aza-5-ethyl-3,7-dioxabicyclo(3.3.0)octane1H,3H,5H-Oxazolo[3,4-c]oxazole, 7a-ethyldihydro-5-ethyl-1-aza-3,7-dioxabicyclo(3.3.0)octane1H,3H,5H-Oxazolo(3,4-c)oxazone, 7a-ethyldihydro-RefChem:8570987-ETHYLBICYCLOOXAZOLIDINE [INCI]1H,3H,5H-Oxazolo3,4-coxazole, 7a-ethyldihydro-231-810-47a-Ethyltetrahydro-1H-oxazolo[3,4-c]oxazoleZoldine ZENeosyn TX
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

0.3%

Other restrictions

Not to be used in oral products and in products applied on mucous membranes

INCI glossary name

7-ETHYLBICYCLOOXAZOLIDINE

Chemical name

5-Ethyl-3,7-dioxa-1-azabicyclo[3.3.0] octane

Chemical / IUPAC name

5-Ethyl-3,7-dioxa-1-azabicyclo[3.3.0] octane

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
7747-35-5
EC
231-810-4
Annex
V
Entry number
49

Inventory links for 7-ETHYLBICYCLOOXAZOLIDINE

Direct matches are limited for this record, so nearby entries from Annex V are shown as well.

Annex V 48
Nearby record in the same annex

GLUTARAL

CAS: 111-30-8
EC: 203-856-5
Annex V 50
Nearby record in the same annex

chlorphenesin

CAS: 104-29-0
EC: 203-192-6
Annex V 52
Nearby record in the same annex

SILVER CHLORIDE

CAS: 7783-90-6
EC: 232-033-3

What Annex V means for 7-ETHYLBICYCLOOXAZOLIDINE

7-ETHYLBICYCLOOXAZOLIDINE is an approved preservative listed in Annex V of EU Cosmetics Regulation 1223/2009. Only substances on this positive list may be used as cosmetic preservatives in the EU.

Each preservative entry specifies maximum permitted concentrations and applicable product scope. Concentrations must not exceed the listed maximum. Some preservatives require warning statements on the product label.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Use concentration must not exceed: 0.3%
  • Verify the preservative is effective at the permitted concentration for your matrix.

Frequently asked questions

Yes. 7-ETHYLBICYCLOOXAZOLIDINE is listed in Annex V of EU Cosmetics Regulation 1223/2009 as a permitted preservative. It may be used in cosmetics up to the maximum concentration specified above, within the permitted product scope.

CAS 7747-35-5 is the unique numerical identifier assigned to 7-ETHYLBICYCLOOXAZOLIDINE by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 0.3% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex V record 7-ETHYLBICYCLOOXAZOLIDINE

This page summarizes one Annex V record for 7-ETHYLBICYCLOOXAZOLIDINE from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex V conditions for 7-ETHYLBICYCLOOXAZOLIDINE, but confirm any final regulatory decision against the current official annex wording and source files.

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