Annex V Entry 44 15/01/2015

BEHENTRIMONIUM CHLORIDE (1) / CETRIMONIUM BROMIDE / CETRIMONIUM CHLORIDE (2)/ LAURTRIMONIUM BROMIDE / LAURTRIMONIUM CHLORIDE / STEARTRIMONIUM BROMIDE / STEARTRIMONIUM CHLORIDE (2)

Q: How is the maximum concentration of BEHENTRIMONIUM CHLORIDE (1) / CETRIMONIUM BROMIDE / CETRIMONIUM CHLORIDE (2)/ LAURTRIMONIUM BROMIDE / LAURTRIMONIUM CHLORIDE / STEARTRIMONIUM BROMIDE / STEARTRIMONIUM CHLORIDE (2) calculated in a finished product?

The maximum concentration of 0.1% applies to the substance in the ready-to-use cosmetic product. When supplied as part of a blend or mixture, the calculation must account for contributions from all sources in the formulation.

Q: How do I check if my product formula contains BEHENTRIMONIUM CHLORIDE (1) / CETRIMONIUM BROMIDE / CETRIMONIUM CHLORIDE (2)/ LAURTRIMONIUM BROMIDE / LAURTRIMONIUM CHLORIDE / STEARTRIMONIUM BROMIDE / STEARTRIMONIUM CHLORIDE (2)?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

Alkyl (C12-C22) trimethyl ammonium bromide and chloride

BEHENTRIMONIUM CHLORIDE (1) / CETRIMONIUM BROMIDE / CETRIMONIUM CHLORIDE (2)/ LAURTRIMONIUM BROMIDE / LAURTRIMONIUM CHLORIDE / STEARTRIMONIUM BROMIDE / STEARTRIMONIUM CHLORIDE (2) appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: 0.1%.

Permitted preservative— Annex V, EU Regulation 1223/2009

Max conc.: 0.1%

Entry: 44

Chemical identity and properties

PubChem 2D chemical structure for CAS 1119-94-4

CAS 1119-94-4PubChem CID 14249

Dodecyltrimethylammonium bromide

Dodecyltrimethylammonium bromide is a bromide salt and a quaternary ammonium salt. It has a role as a surfactant. It contains a dodecyltrimethylammonium ion. — ChEBI

IUPAC name: dodecyl(trimethyl)azanium bromide

Molecular formula: C15H34BrN
Molecular weight: 308.34 g/mol
Exact mass: 307.18746 Da
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 2
Defined stereocentres: 0

Also known as

DctabDTABLaurtrimonium bromideLauryltrimethylammonium bromideLTABMorpan DDTAB (surfactant)1-Dodecanaminium, N,N,N-trimethyl-, bromide

16 more reported names

Trimethyllaurylammonium bromideTrimethyldodecylammonium bromideFSM 23N-Lauryl-N,N,N-trimethylammonium bromideN,N,N-Trimethyldodecan-1-ammonium bromideN,N,N-Trimethyl-1-dodecanaminiuim bromideLauryltrimethylaminium bromide6IC8NZ97S2CHEBI:282662ammonium, dodecyltrimethyl-,bromideRefChem:920574214-290-3N,N,N-trimethyldodecan-1-aminium bromideDODECYL TRIMETHYL AMMONIUM BROMIDEdodecyl(trimethyl)azanium;bromideDodecyltrimethylammonium (bromide)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:282662
ChEMBL:CHEMBL109873
EPA DTXSID:DTXSID5044366

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match14249

Attributed physical-property, hazard, environmental and use annotations.

Physical Description: Dry Powder Source: EPA Chemical Data Reporting (CDR)
Physical Description: White to light yellow odorless powder; Hygroscopic; [Acros Organics MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Note: This chemical does not meet GHS hazard criteria for 2.2% (2 of 89) of reports. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H301 (20.2%): Toxic if swallowed [Danger Acute toxicity, oral]; H302 (53.9%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (96.6%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (23.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (96.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (62.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H400 (69.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (66.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 89 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 89 reports by companies.; There are 17 notifications provided by 87 of 89 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: NITE-CMC
GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
Precautionary Statement Codes: P264, P270, P273, P280, P301+P316, P302+P352, P321, P330, P332+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Precautionary Statement Codes: P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concluded the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Laurtrimonium Bromide... Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)

Industry Uses: Defoamer Source: EPA Chemical Data Reporting (CDR)

Cosmetic Ingredient Review Link: CIR ingredient: Laurtrimonium Bromide Source: Cosmetic Ingredient Review (CIR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 112-00-5

CAS 112-00-5PubChem CID 8152

Dodecyltrimethylammonium chloride

The CIR Expert Panel concluded the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Laurtrimonium Chloride... — Cosmetic Ingredient Review (CIR)

IUPAC name: dodecyl(trimethyl)azanium chloride

Molecular formula: C15H34ClN
Molecular weight: 263.89 g/mol
Exact mass: 263.2379778 Da
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 2
Defined stereocentres: 0

Also known as

DODECYL TRIMETHYL AMMONIUM CHLORIDEDTACAlicopLauryltrimethylammonium chlorideLaurtrimonium chlorideCation BBAliquat 4Dehyquart LT

16 more reported names

Cation FBNissan Cation BBn-Dodecyltrimethylammonium chlorideArquad 12Arquad 12DTrimethyllaurylammonium chlorideCatiogen LNissan Cation FBQuartamin 24PQuartamin 24WArquad 12/50Redicote E 5Rewoquat B 18Radiaquat 6465Trimethyldodecylammonium chlorideCatinal LTC 35A

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External database identifiers

ChEMBL:CHEMBL1884887
EPA DTXSID:DTXSID1026900

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match8152

Attributed physical-property, hazard, environmental and use annotations.

Physical Description: CBI; Liquid Source: EPA Chemical Data Reporting (CDR)
Physical Description: Solid; [EPA ChAMP: Initial Risk-Based Prioritization Document] White to light yellow powder and chunks; Hygroscopic; [Acros Organics MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Vapor Pressure: 0.00000001 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Note: This chemical does not meet GHS hazard criteria for 2.5% (12 of 476) of reports. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (87.2%): Harmful if swallowed [Warning Acute toxicity, oral]; H314 (31.1%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H315 (64.1%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (28.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (54%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (30%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H400 (80.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (27.9%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]; H411 (10.1%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 476 reports by companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 12 of 476 reports by companies.; There are 27 notifications provided by 464 of 476 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: NITE-CMC
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: NITE-CMC
Precautionary Statement Codes: P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: NITE-CMC
GHS Hazard Statements: Not Classified Source: NITE-CMC
Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Precautionary Statement Codes: P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concluded the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Laurtrimonium Chloride... Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)

Consumer Uses: Corrosion inhibitor; Surfactant (surface active agent) Source: EPA Chemical Data Reporting (CDR)

Industry Uses: CBI; Surfactant (surface active agent); Corrosion inhibitor; Etching agent Source: EPA Chemical Data Reporting (CDR)

Cosmetic Ingredient Review Link: CIR ingredient: Laurtrimonium Chloride Source: Cosmetic Ingredient Review (CIR)
Sources/Uses: Typical uses of category members include surfactants, intermediates, anti-scaling agents, fabric softeners, multifunctional laundry detergents, antistatic sprays, germicides, deodorizers, emulsifiers, hair-care products, industrial lubricants, and corrosion inhibitors; [EPA ChAMP: Initial Risk-Based Prioritization Document] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Industrial Processes with risk of exposure: Using Disinfectants or Biocides [Category: Clean] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 112-02-7

CAS 112-02-7PubChem CID 8154

Hexadecyltrimethylammonium chloride

Cetyltrimethylammonium chloride is the organic chloride salt of cetyltrimethylammonium. It has a role as a surfactant. It is a quaternary ammonium salt and an organic chloride salt. It contains a cetyltrimethylammonium ion. — ChEBI

IUPAC name: hexadecyl(trimethyl)azanium chloride

Molecular formula: C19H42ClN
Molecular weight: 320.0 g/mol
Exact mass: 319.3005780 Da
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 2
Defined stereocentres: 0

Also known as

Cetrimonium chlorideN-Hexadecyltrimethylammonium chlorideDehyquart AGenamin CTACAliquat 6Cetyl trimethyl ammonium chlorideCETACHTAC

16 more reported names

Adogen 444Surfroyal CTACMorpan CHAQuartamin 60WTrimethylcetylammonium chlorideArquad 16-29Arquad 16-50Ammonyx Cetac 30TRIMETHYLHEXADECYLAMMONIUM CHLORIDEIntexsan CTC 29Intexsan CTC 50Arquad 16Barquat CT 29Intexan CTC 29Palmityltrimethylammonium chlorideVariquat E 228

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:53581
ChEMBL:CHEMBL1895807
EPA DTXSID:DTXSID6026901
PubMed:10124

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match8154

Attributed physical-property, hazard, environmental and use annotations.

Autoignition Temperature: 750 °F (USCG, 1999) Source: CAMEO Chemicals
Autoignition Temperature: 750 °F /ISOPROPYL ALCOHOL SOLN OF CETYLTRIMETHYLAMMONIUM CHLORIDE/ Source: Hazardous Substances Data Bank (HSDB)

Boiling Point: 180 °F at 760 mmHg (isopropyl alcohol) (USCG, 1999) Source: CAMEO Chemicals

Density: 0.9 at 77 °F (approx.) (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals

Flash Point: 69 °F (USCG, 1999) Source: CAMEO Chemicals

LogP: log Kow= 3.23 Source: Hazardous Substances Data Bank (HSDB)

Physical Description: Hexadecyltrimethylammonium chloride appears as colorless to pale yellow liquid with an odor of rubbing alcohol. Floats or sinks in water. (USCG, 1999) Source: CAMEO Chemicals
Physical Description: Liquid; CBI Source: EPA Chemical Data Reporting (CDR)
Physical Description: Solution: Clear to pale yellow liquid; [HSDB] White powder; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Solubility: Water solubility: 440 mg/l at 30 °C Source: Hazardous Substances Data Bank (HSDB)

First Aid: INGESTION: do NOT induce vomiting; drink large quanities of fluid and call a physician immediately.; EYES: flush with water for at least 15 min. and call a physician.; SKIN: flush with water. (USCG, 1999) Source: CAMEO Chemicals

Note: This chemical does not meet GHS hazard criteria for 0.5% (5 of 1105) of reports. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (49%): Harmful if swallowed [Warning Acute toxicity, oral]; H311 (28.6%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H314 (41.5%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H315 (52.3%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (85.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335 (44.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H400 (99.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (40.9%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P361+P364, P362+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 1105 reports by companies from 42 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 5 of 1105 reports by companies.; There are 41 notifications provided by 1100 of 1105 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: NITE-CMC
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
Signal: Warning Source: NITE-CMC
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: NITE-CMC
Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concluded the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Cetrimonium Chloride... Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)

Environmental Bioconcentration: An estimated BCF of 71 was calculated for trimethylhexadecylammonium chloride(SRC), using an estimated log Kow of 3.23(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate. Source: Hazardous Substances Data Bank (HSDB)

Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2.2X10+5(SRC), determined from a structure estimation method(2), indicates that trimethylhexadecylammonium chloride is expected to be immobile in soil(SRC). Volatilization of trimethylhexadecylammonium chloride from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.9X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Trimethylhexadecylammonium chloride is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.8X10-10 mm Hg(SRC), determined from a fragment constant method(4). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2.2X10+5(SRC), determined from an estimation method(2), indicates that trimethylhexadecylammonium chloride is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.9X10-10 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 71(SRC), from its log Kow of 3.23(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is moderate. The MITI, closed bottle, and Sturm tests revealed no degradation after 10 days, microbial growth after 17 days, and 84% degradation after 13 days, respectively(8). 10-20 ppm trimethylhexadecylammonium chloride was degraded with a half-life of 3.1 days in freshwater collected from the Ohio river 1 mile below discharge from a municipal treatment plant at 20 °C and pH 6.9(9). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethylhexadecylammonium chloride, which has an estimated vapor pressure of 2.8X10-10 mm Hg at 25 °C(SRC), using a fragment constant estimation method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase trimethylhexadecylammonium chloride may be removed from the air by wet and dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)

Consumer Uses: Cleaning agent; Corrosion inhibitor; Softener and conditioner; Surface modifier; Surfactant (surface active agent) Source: EPA Chemical Data Reporting (CDR)

Industry Uses: Corrosion inhibitor; Processing aids, specific to petroleum production; Softener and conditioner; Surface modifier; CBI; Processing aids not otherwise specified; Surfactant (surface active agent) Source: EPA Chemical Data Reporting (CDR)

Cosmetic Ingredient Review Link: CIR ingredient: Cetrimonium Chloride Source: Cosmetic Ingredient Review (CIR)
Sources/Uses: Available as a 25% aqueous solution and 50% solution in isopropyl alcohol and water for use in antifungal formulations and hair conditioners; Also used as a disinfectant/germicide, cationic detergent, fermentation aid, dispersant, coagulant for antibiotic production, and antistatic and softening agent for textile finishes; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Industrial Processes with risk of exposure: Using Disinfectants or Biocides [Category: Clean]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: USED IN ANTIFUNGAL FORMULATION; IN HAIR CONDITIONER FORMULATION; DISINFECTANT; CATIONIC DETERGENT Source: Hazardous Substances Data Bank (HSDB)
Uses: SOFTENER IN HAIR TREATMENTS, EG, CREME RINSES Source: Hazardous Substances Data Bank (HSDB)
Uses: FERMENTATION AID Source: Hazardous Substances Data Bank (HSDB)
Uses: GERMICIDE Source: Hazardous Substances Data Bank (HSDB)
Uses: For more Uses (Complete) data for TRIMETHYLHEXADECYLAMMONIUM CHLORIDE (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 112-03-8

CAS 112-03-8PubChem CID 8155

Stearyltrimethylammonium chloride

Stearyltrimethylammonium chloride is an organic molecular entity. — ChEBI

IUPAC name: trimethyl(octadecyl)azanium chloride

Molecular formula: C21H46ClN
Molecular weight: 348.0 g/mol
Exact mass: 347.3318782 Da
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 2
Defined stereocentres: 0

Also known as

Trimethylstearylammonium chlorideStacCation ABAliquat 7Nissan cation ABQuaternium-10Arquad 18Stearyl trimethyl ammonium chloride

16 more reported names

Arquad 18-50Monostearyl trimethyl ammonium chlorideN,N,N-Trimethyl-1-octadecanaminium chlorideRefChem:871332N,N,N-trimethyloctadecan-1-aminium chlorideTrimethyloctadecylammonium chlorideOCTADECYLTRIMETHYLAMMONIUM CHLORIDE1-Octadecanaminium, N,N,N-trimethyl-, chlorideSteartrimonium chlorideStearyl trimethyl ammoium chlorideOctadecy trimethyl ammonium chloridetrimethyl octadecyl ammonium chlorideOctadecyl trimethyl ammonium chloridetrimethyloctadecylamine, chloridetrimethyl(octadecyl)azanium;chlorideEINECS 203-929-1

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External database identifiers

ChEBI:CHEBI:81710
ChEMBL:CHEMBL118745
EPA DTXSID:DTXSID1026902

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match8155

Attributed physical-property, hazard, environmental and use annotations.

Physical Description: CBI; Large Crystals Source: EPA Chemical Data Reporting (CDR)

Carcinogen Classification: Not listed by IARC. Certain nitrosamines are classified by IARC as either probably or possibly carcinogenic to humans (Groups 2A and 2B, respectively). (L135) Source: Toxin and Toxin Target Database (T3DB)

Exposure Routes: Oral (A2880) ; inhalation (A2880) ; dermal (L1889) Source: Toxin and Toxin Target Database (T3DB)

Note: This chemical does not meet GHS hazard criteria for 3.7% (10 of 268) of reports. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (88.1%): Harmful if swallowed [Warning Acute toxicity, oral]; H311 (54.5%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H312 (19.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H314 (79.1%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318 (29.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H400 (71.6%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (78.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P260, P262, P264, P264+P265, P270, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P361+P364, P362+P364, P363, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 268 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 10 of 268 reports by companies.; There are 18 notifications provided by 258 of 268 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: NITE-CMC
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal] Source: NITE-CMC
Precautionary Statement Codes: P264, P270, P280, P301+P317, P302+P352, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement) Source: NITE-CMC
Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Precautionary Statement Codes: P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Health Effects: Quaternium-10 may react to produce nitrosamines, which are believed to be carcinogenic. (L1890) Source: Toxin and Toxin Target Database (T3DB)

Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concluded the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Steartrimonium Chloride... Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)
Toxicity Summary: While quaternium-10 itself is not toxic, it is a nitrosating agent. Nitrosating agents may decompose and/or react to cause nitrosamine contamination. Nitrosamines are produced from secondary amines and amides in the presence of nitrite ions and are believed to be carcinogenic. Once in the body, nitrosamines are activated by cytochrome P-450 enzymes. They are then believed to induce their carcinogenic effects by forming DNA adducts at the N- and O-atoms. (L1889, L1890, A2878, A2879, A2880) Source: Toxin and Toxin Target Database (T3DB)

Cosmetic Ingredient Review Link: CIR ingredient: Steartrimonium Chloride Source: Cosmetic Ingredient Review (CIR)
Uses: Quaternium-10 is a quaternary ammonium salt found in numerous cosmetics. (L1890) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 1120-02-1

CAS 1120-02-1PubChem CID 70708

Octadecyltrimethylammonium bromide

The CIR Expert Panel concluded the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Steartrimonium Bromide... — Cosmetic Ingredient Review (CIR)

IUPAC name: trimethyl(octadecyl)azanium bromide

Molecular formula: C21H46BrN
Molecular weight: 392.5 g/mol
Exact mass: 391.28136 Da
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 2
Defined stereocentres: 0

Also known as

Steartrimonium BromideBPW1DD4IZ8CATINAL STBODTEA Br cpdRefChem:889163214-294-5Trimethyloctadecylammonium bromideOctMAB

16 more reported names

N,N,N-Trimethyloctadecan-1-aminium bromideStearyltrimethylammonium BromideOctadecy trimethyl ammonium bromideTrimethylstearylammonium Bromide1-Octadecanaminium, N,N,N-trimethyl-, bromideOTABTrimethyl-1-octylammonium bromidetrimethyl(octadecyl)azanium;bromideStearyltrimethylammonium bromide (STAB)Trimethyloctadecylammonium (bromide)1-Octadecanaminium, N,N,N-trimethyl-, bromide (1:1)UNII-BPW1DD4IZ8C21H46BrNStearyl Trimethyl Ammoium bromideEINECS 214-294-5Ammonium, trimethyloctadecyl-, bromide

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External database identifiers

ChEMBL:CHEMBL109458
EPA DTXSID:DTXSID40883652

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match70708

Attributed physical-property, hazard, environmental and use annotations.

Physical Description: White hygroscopic powder; [Sigma-Aldrich MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (13%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (10.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (10.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (89.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (87%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 46 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concluded the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Steartrimonium Bromide... Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)

Cosmetic Ingredient Review Link: CIR ingredient: Steartrimonium Bromide Source: Cosmetic Ingredient Review (CIR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 17301-53-0

CAS 17301-53-0PubChem CID 3014969

Behentrimonium Chloride

The CIR Expert Panel concluded the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Behentrimonium Chloride... — Cosmetic Ingredient Review (CIR)

IUPAC name: docosyl(trimethyl)azanium chloride

Molecular formula: C25H54ClN
Molecular weight: 404.2 g/mol
Exact mass: 403.3944784 Da
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 2
Defined stereocentres: 0

Also known as

Docosyltrimethylammonium chlorideX7GNG3S47T1-Docosanaminium, N,N,N-trimethyl-, chlorideEINECS 241-327-0BEHENTRIMONIUMGENAMIN BTLFN,N,N-Trimethyl-1-docosanaminium chloride1-Docosanaminium, N,N,N-trimethyl-, chloride (1:1)

16 more reported names

behenyltrimethylammonium chlorideVARISOFT BT 85 PELLETSINCROQUAT BEHENYL TMC-85RefChem:561201BEHENTRIMONIUM CHLORIDE [INCI]241-327-0926-569-3N,N,N-Trimethyldocosan-1-aminium chloridedocosyl(trimethyl)azanium;chlorideUNII-X7GNG3S47TBehentrimonium Chloride (>80%)docosyl(trimethyl)azanium,chlorideBehenyltrimonium chloridebehenyltrimethylammoniumchloridedocosyltrimethylazanium chlorideTrimethylbehenylammonium chloride

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External database identifiers

EPA DTXSID:DTXSID60884964

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 57-09-0

CAS 57-09-0PubChem CID 5974

Hexadecyltrimethylammonium Bromide

Cetyltrimethylammonium bromide is the organic bromide salt that is the bromide salt of cetyltrimethylammonium; one of the components of the topical antiseptic cetrimide. It has a role as a detergent and a surfactant. It is a quaternary ammonium salt and an organic bromide salt. It contains a cetyltrimethylammonium ion. — ChEBI

IUPAC name: hexadecyl(trimethyl)azanium bromide

Molecular formula: C19H42BrN
Molecular weight: 364.4 g/mol
Exact mass: 363.25006 Da
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 2
Defined stereocentres: 0

Also known as

Cetrimonium bromideCetyltrimethylammonium bromideBromatCETABCentimideCtmabAcetoquat CTABCee dee

16 more reported names

Cetyl trimethyl ammonium bromideTrimethylcetylammonium bromideBromuro de cetrimonioN-Cetyltrimethylammonium bromideBromure de cetrimoniumCetrimonii bromidumTrimethylhexadecylammonium bromideCetrimonio bromuroN-HEXADECYLTRIMETHYLAMMONIUM BROMIDEPalmityltrimethyl ammonium bromideN,N,N-Trimethyl-1-hexadecanaminium bromideN,N,N-Trimethylcetylammonium bromideSumquat 6030N-Hexadecyl-N,N,N-trimethylammonium bromideL64N7M9BWRNSC-32927

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External database identifiers

ChEBI:CHEBI:3567
ChEMBL:CHEMBL307346
EPA DTXSID:DTXSID5037028

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

0.1%

INCI glossary name

BEHENTRIMONIUM CHLORIDE (1) / CETRIMONIUM BROMIDE / CETRIMONIUM CHLORIDE (2)/ LAURTRIMONIUM BROMIDE / LAURTRIMONIUM CHLORIDE / STEARTRIMONIUM BROMIDE / STEARTRIMONIUM CHLORIDE (2)

Chemical name

Alkyl (C12-C22) trimethyl ammonium bromide and chloride

Regulatory information

Regulation

(EU) 2014/866

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS

17301-53-0 / 57-09-0 / 112-02-7 / 1119-94-4 / 112-00-5 / 1120-02-1 / 112-03-8

241-327-0 / 200-311-3 / 203-928-6 / 214-290-3 / 203-927-0 / 214-294-5 / 203-929-1

Annex

Entry number