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Annex II Entry 416 20/01/2023

Cells, tissues or products of human origin

Cells, tissues or products of human origin is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 416

Record details

Chemical name

Cells, tissues or products of human origin

Chemical / IUPAC name

Cells, tissues or products of human origin

Regulatory information

Regulation

(EC) 2009/1223

Identified ingredients

Key data

CAS
—
EC
—
Annex
II
Entry number
416

Inventory links for Cells, tissues or products of human origin

Inventory Restriction reference
Ref 86073

RH-POLYPEPTIDE-19

CAS: 93585-89-8 / 105186-99-0
EC: - / -
Inventory Restriction reference
Ref 86075

RH-POLYPEPTIDE-25

CAS: 90804-20-9 / 102524-44-7 / 453656-85-4
EC: - / - / -

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 409
Nearby record in the same annex

Pyrogallol

CAS: 87-66-1
EC: 201-762-9

What Annex II means for Cells, tissues or products of human origin

Cells, tissues or products of human origin is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009. No concentration limit applies — the presence of this substance in any cosmetic product placed on the EU market is not permitted regardless of use level.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 192 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Cells, tissues or products of human origin is listed in Annex II of EU Cosmetics Regulation 1223/2009 as a prohibited substance. It must not be present in any cosmetic product placed on the EU market at any concentration.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Cells, tissues or products of human origin

This page summarizes one Annex II record for Cells, tissues or products of human origin from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Cells, tissues or products of human origin, but confirm any final regulatory decision against the current official annex wording and source files.

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