What does the restriction note for RH-POLYPEPTIDE-12 mean?

The restriction field for RH-POLYPEPTIDE-12 reads: II/416. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 453656-85-4?

CAS 453656-85-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains RH-POLYPEPTIDE-12?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8518415/10/2010

RH-POLYPEPTIDE-12

RH-POLYPEPTIDE-12 is linked to 1 EU annex record on this page. Inventory note: II/416.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

What the official INCI name states

The official label identifies a peptide- or protein-related cosmetic material.

Identity type from wording: peptide_or_protein

This structure is derived only from the official label wording. It does not establish composition, concentration, chemical equivalence, safety or regulatory permission.

Inventory details for RH-POLYPEPTIDE-12

INCI name

RH-POLYPEPTIDE-12

Description

rh-Polypeptide-12 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Interleukin-4. It contains a maximum of 153 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids

Record provenance

Inventory reference: 85184
Imported identity: RH-POLYPEPTIDE-12
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for RH-POLYPEPTIDE-12

Annex II Restriction reference

Entry 416

Cells, tissues or products of human origin

Key data

CAS

453656-85-4

—

Restriction

II/416

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#24284 · rh-POLYPEPTIDE-12

Records sharing a CAS or EC identity

RH-POLYPEPTIDE-6

Ingredients with overlapping formulation functions

RH-POLYPEPTIDE-1SKIN CONDITIONING, SKIN PROTECTING

RH-POLYPEPTIDE-10SKIN CONDITIONING

RH-POLYPEPTIDE-11SKIN CONDITIONING

RH-POLYPEPTIDE-11 DIPEPTIDE-19 OLIGOPEPTIDE-91 HEXAPEPTIDE-40HAIR CONDITIONING, SKIN CONDITIONING, SKIN PROTECTING

RH-POLYPEPTIDE-13SKIN CONDITIONING

RH-POLYPEPTIDE-14SKIN CONDITIONING

RH-POLYPEPTIDE-15SKIN CONDITIONING

RH-POLYPEPTIDE-16SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How RH-POLYPEPTIDE-12 appears in the CosIng inventory

The CosIng inventory lists RH-POLYPEPTIDE-12 as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

RH-POLYPEPTIDE-12 is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

RH-POLYPEPTIDE-12 appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for RH-POLYPEPTIDE-12 reads: "II/416". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, RH-POLYPEPTIDE-12 carries the following function designation(s):

SKIN CONDITIONING

CAS 453656-85-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for RH-POLYPEPTIDE-12

This page combines the CosIng inventory entry for RH-POLYPEPTIDE-12 with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research RH-POLYPEPTIDE-12 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Find other inventory ingredients and annex entries related to RH-POLYPEPTIDE-12, its identifiers or nearby name variants.