What is CAS 119-34-6 for 4-Amino-2-nitrophenol?

CAS 119-34-6 is the unique numerical identifier assigned to 4-Amino-2-nitrophenol by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex II Entry 412 20/10/2010

4-Amino-2-nitrophenol

Q: How do I check if my product formula contains 4-Amino-2-nitrophenol?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

4-Amino-2-nitrophenol is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 412

Chemical identity and properties

PubChem 2D chemical structure for CAS 119-34-6

CAS 119-34-6PubChem CID 3417419

4-Amino-2-Nitrophenol

4-Amino-2-nitrophenol is a member of 2-nitrophenols. — ChEBI

IUPAC name: 4-amino-2-nitrophenol

Molecular formula: C6H6N2O3
Molecular weight: 154.12 g/mol
Exact mass: 154.03784206 Da
XLogP3: 1.0
Topological polar surface area: 92.1 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

4-Hydroxy-3-nitroanilinePhenol, 4-amino-2-nitro-Fourrine 57Fourrine Brown PR2-Nitro-4-aminophenolOxidation Base 253-Nitro-4-hydroxyanilineFourrine Brown Propyl

16 more reported names

o-Nitro-p-aminophenolp-Amino-o-nitrophenolC.I. Oxidation Base 251-Amino-3-nitro-4-hydroxybenzeneNCI-C03963CI Oxidation Base 25C.I. 76555ortho-Nitro-para-aminophenolCI 76555N3499RCQ6BNSC-56809DTXCID4064CI-76555RefChem:97704204-316-14-Amino-2-nitrofenol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:82385
ChEMBL:CHEMBL1516868
EPA DTXSID:DTXSID6020064
PubMed:21962688
PubMed:20086194
PubMed:17389084
PubMed:12498276

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match3417419

Attributed physical-property, hazard, environmental and use annotations.

Boiling Point: 110 °C at 12 mm Hg Source: Hazardous Substances Data Bank (HSDB)

Color/Form: Dark-red plates or needles from water and ethanol Source: Hazardous Substances Data Bank (HSDB)

Dissociation Constants: pKa = 7.81 at 25 °C (phenol) Source: Hazardous Substances Data Bank (HSDB)

LogP: log Kow = 0.96 Source: Hazardous Substances Data Bank (HSDB)

Melting Point: 261 °F (NTP, 1992) Source: CAMEO Chemicals
Melting Point: 131 °C Source: Hazardous Substances Data Bank (HSDB)

Physical Description: 4-amino-2-nitrophenol appears as dark red plates, needles or reddish-purple powder. Melting point 125-127 °C. Source: CAMEO Chemicals
Physical Description: Dark red solid; [HSDB] Red-brown crystalline powder; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Solubility: less than 0.1 mg/mL at 70 °F (NTP, 1992) Source: CAMEO Chemicals
Solubility: Soluble in water, ethanol, diethyl ether; slightly soluble in dimethylsulfoxide Source: Hazardous Substances Data Bank (HSDB)

Vapor Pressure: 0.0000352 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

IARC Carcinogenic Agent: 4-Amino-2-nitrophenol Source: International Agency for Research on Cancer (IARC)
IARC Carcinogenic Classes: Group 3: Not classifiable as to its carcinogenicity to humans Source: International Agency for Research on Cancer (IARC)
IARC Monographs: Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals; Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) Source: International Agency for Research on Cancer (IARC)
Publication Year: 1987 Source: International Agency for Research on Cancer (IARC)
Evaluation Year: 1987 Source: International Agency for Research on Cancer (IARC)
Substance: 4-Amino-2-nitrophenol Source: NTP Technical Reports
NTP Technical Report: TR-094: Bioassay of 4-Amino-2-nitrophenol for Possible Carcinogenicity (CASRN 119-34-6) (1978 ) Source: NTP Technical Reports
Peer Review Date: 04/26/78 Source: NTP Technical Reports
Conclusion for Male Rat: Clear Evidence Source: NTP Technical Reports
Conclusion for Female Rat: Equivocal Evidence Source: NTP Technical Reports
Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
Conclusion for Female Mice: No Evidence Source: NTP Technical Reports

First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals

Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (12.8%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (12.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335 (10.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H341 (10.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P203, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 47 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Cosmetic Ingredient Review Conclusion: Based on the data contained in this report, the CIR Expert Panel concludes that 2-amino-3-nitrophenol, 2-amino-4-nitrophenol,2-amino-4-nitrophenol sulfate, 2-amino-5-nitrophenol, 4-amino-3-nitrophenol, 3-nitro-p-hydroxyethylaminophenol, and 4-hydroxypropylamino-3-nitrophenol are safe as hair dye ingredients in the practices of use and concentration as described in this safety assessment, but the data are insufficient to make a determination of safety for 4-amino-2-nitrophenol. Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Ingredients for which the data are insufficient and their use in cosmetics is not supported Source: Cosmetic Ingredient Review (CIR)

Environmental Bioconcentration: An estimated BCF of 3 was calculated for 4-amino-2-nitrophenol(SRC), using a log Kow of 0.96(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)

Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 79(SRC), determined from a log Kow of 0.96(2) and a regression-derived equation(3), indicates that 4-amino-2-nitrophenol is expected to have high mobility in soil(SRC). Volatilization of 4-amino-2-nitrophenol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.2X10-12 atm-cu m/mole(SRC), using a fragment constant estimation method(4)). 4-Amino-2-nitrophenol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.5X10-5 mm Hg(SRC), determined from a fragment constant method(5). Incomplete data were available regarding the biodegradation potential of 4-amino-2-nitrophenol(SRC, 2008); however, Nocardia v. was able to use this compound as a carbon source for limited growth under aerobic conditions(6). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 79(SRC), determined from a log Kow of 0.96(2) and a regression-derived equation(3), indicates that 4-amino-2-nitrophenol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.3X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(6), suggests bioconcentration in aquatic organisms is low(SRC). Incomplete data were available regarding the biodegradation potential of 4-amino-2-nitrophenol(SRC, 2008); however, Nocardia v. was able to use this compound as a carbon source for limited growth under aerobic conditions(7). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 4-amino-2-nitrophenol, which has an estimated vapor pressure of 3.5X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 4-amino-2-nitrophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.3 days(SRC), calculated from its rate constant of 7.0X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3) Particulate-phase 4-amino-2-nitrophenol may be removed from the air by wet or dry deposition(SRC). 4-Amino-2-nitrophenol contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Cosmetic Ingredient Review Link: CIR ingredient: 4-Amino-2-Nitrophenol Source: Cosmetic Ingredient Review (CIR)
Sources/Uses: Used to dye furs, to dye hair, and to etch copper printing plates; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Industrial Processes with risk of exposure: Fur Dressing and Dyeing [Category: Industry]; Dressing Hair [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: 4-Amino-2-nitrophenol is used in dyeing furs a beige or deep reddish brown. It is also used in hair dyes. /SRP: FORMER/ Source: Hazardous Substances Data Bank (HSDB)
Uses: 4-Amino-2-nitrophenol is used in the etching of copper printing plates. Source: Hazardous Substances Data Bank (HSDB)
Uses: ... Used in hair dyes ... used in textile dye synthesis. /SRP: FORMER/ Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

4-Amino-2-nitrophenol

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

4-AMINO-2-NITROPHENOL

Key data

CAS

119-34-6

204-316-1

Annex

Entry number

412

Inventory links for 4-Amino-2-nitrophenol

Inventory Restriction reference

Ref 54208