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Annex II Entry 421 15/10/2010

1,1,3,3,5-Pentamethyl-4,6-dinitroindane (Moskene)

1,1,3,3,5-Pentamethyl-4,6-dinitroindane (Moskene) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 421

Chemical identity and properties

PubChem 2D chemical structure for CAS 116-66-5
CAS 116-66-5PubChem CID 67005

Moskene

IUPAC name
1,1,3,3,5-pentamethyl-4,6-dinitro-2H-indene
Molecular formula
C14H18N2O4
Molecular weight
278.30 g/mol
Exact mass
278.12665706 Da
XLogP3
4.5
Topological polar surface area
91.6 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

Musk moskene1H-Indene, 2,3-dihydro-1,1,3,3,5-pentamethyl-4,6-dinitro-1,1,3,3,5-Pentamethyl-4,6-dinitroindan1Q49IC9FAW1,1,3,3,5-Pentamethyl-4,6-dinitro-2,3-dihydro-1H-indeneNSC-60035RefChem:159824204-149-4
16 more reported names
1,1,3,3,5-Pentamethyl-4,6-dinitroindaneMusk moskine4,6-Dinitro-1,1,3,3,5-pentamethylindane1,1,3,3,5-Pentamethyl-4,6-dinitrolindanIndan, 1,1,3,3,5-pentamethyl-4,6-dinitro-Indan, 4,6-dinitro-1,1,3,3,5-pentamethyl-2,3-Dihydro-1,1,3,3,5-Pentamethyl-4,6-Dinitro-1H-IndeneCCRIS 7622EINECS 204-149-4NSC 60035UNII-1Q49IC9FAWBRN 2163411AI3-280254,6-Dinitro-1,1,3,3,5-pentamethylindanMaybridge1_007103Oprea1_114805
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match67005

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 92.6% (138 of 149) of all reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 138 of 149 companies (only 7.4% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 149 reports by companies from 3 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 138 of 149 reports by companies.; There is 1 notification provided by 11 of 149 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

1,1,3,3,5-Pentamethyl-4,6-dinitroindane (Moskene)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Key data

CAS
116-66-5
EC
204-149-4
Annex
II
Entry number
421

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 1,1,3,3,5-Pentamethyl-4,6-dinitroindane (Moskene)

1,1,3,3,5-Pentamethyl-4,6-dinitroindane (Moskene) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 1,1,3,3,5-Pentamethyl-4,6-dinitroindane (Moskene) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 116-66-5 is the unique numerical identifier assigned to 1,1,3,3,5-Pentamethyl-4,6-dinitroindane (Moskene) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 1,1,3,3,5-Pentamethyl-4,6-dinitroindane (Moskene)

This page summarizes one Annex II record for 1,1,3,3,5-Pentamethyl-4,6-dinitroindane (Moskene) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 1,1,3,3,5-Pentamethyl-4,6-dinitroindane (Moskene), but confirm any final regulatory decision against the current official annex wording and source files.

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