What does the restriction note for NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1 mean?

The restriction field for NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1 reads: II/416. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

How do I check if my formula contains NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9299321/06/2016

NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1

Nicotiana Benthamiana rh-Oligopeptide-1 is a single chain recombinant human peptide, produced by transgenic Nicotiana benthamiana after the transient expression or stable insertion of a copy of a human gene into its DNA.

NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1 is linked to 1 EU annex record on this page. Inventory note: II/416.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

What the official INCI name states

The official label identifies a peptide- or protein-related cosmetic material.

Identity type from wording: peptide_or_protein

This structure is derived only from the official label wording. It does not establish composition, concentration, chemical equivalence, safety or regulatory permission.

Inventory details for NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1

INCI name

NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1

Description

Record provenance

Inventory reference: 92993
Imported identity: NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1
Source update: 21/06/2016

European Commission CosIng source notes

Annex records for NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1

Annex II Restriction reference

Entry 416

Cells, tissues or products of human origin

Key data

CAS

—

The CosIng inventory records no CAS number for this ingredient. That is the absence of an identifier in the source, not a finding about the substance.

—

Restriction

II/416

Function

SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17414 · NICOTIANA BENTHAMIANA rh-OLIGOPEPTIDE-1

Other ingredients from the same source

Nicotiana benthamiana

24 other ingredients in this inventory name the same organism. Sharing a source is not sharing an identity: a leaf extract, a seed oil and a ferment are different materials with different specifications.

and 12 more

Ingredients with overlapping formulation functions

NICKEL BIS (HYDROXY DIPHENYL METHYL PYRROLIDINO METHYL) PYRIDINEDIYL T-BUTYLISO…ANTIOXIDANT, BLEACHING, SKIN CONDITIONING, SKIN PROTECTING

NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-POLYPEPTIDE-133 TETRAPEPTIDE-78SKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS

NICOTIANA BENTHAMIANA R-(S-SOLITARY BEE OLIGOPEPTIDE-1 PENTAPEPTIDE-75 S-PROPIO…ANTIMICROBIAL; SKIN PROTECTING; LYTIC

NICOTIANA BENTHAMIANA R-(S-SPIDER POLYPEPTIDE-6 TRIPEPTIDE-44 SH-POLYPEPTIDE-12…FILM FORMING; SKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS

NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATESKIN CONDITIONING, SKIN PROTECTING

NICOTINOYL HEXAPEPTIDE-44ANTIOXIDANT, SKIN PROTECTING

NICOTINOYL HEXAPEPTIDE-45ANTIOXIDANT, SKIN PROTECTING, UV FILTER

NICOTINOYL HEXAPEPTIDE-56ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1 appears in the CosIng inventory

The CosIng inventory lists NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1 as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1 is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1 appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1 reads: "II/416". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1 carries the following function designation(s):

SKIN PROTECTING

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Source note for NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1

This page combines the CosIng inventory entry for NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1 with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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