CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
ProhibitedBinding ruleCNOfficial English translationOfficial-source import checked

抗感染类药物，包括但不限于三溴沙 仑、抗生素类、二氢速甾醇、乙硫异烟 胺、呋喃唑酮、酮康唑、甲硝唑、呋喃 妥因、磺胺类药物（磺胺和其氨基的一 个或多个氢原子被取代的衍生物）及其 盐类、甲巯咪唑、短杆菌素等 — Anti-infectives, including but not limited to 3,4',5-Tribromosalicylanilide （Tribromsalan （INN） ）（CAS No. 87-10-5）, Antibiotics, Dihydrotachysterol （INN） （CAS No. 67-96-9）, Ethionamide （INN） （CAS No. 536-33-4）, Furazolidone （INN） （CAS No. 67-45-8）, Ketoconazole （CAS No. 65277-42-1）, Metronidazole （CAS No. 443-48-1）, Nitrofurantoin （INN） （CAS No. 67-20-9）, Sulphonamides （sulphanilamide and its derivatives obtained by substitution of one or more H-atoms of the -NH2 groups） and their salts, Thiamazole （INN） （CAS No. 60-56-0）, Thyrothricine （CAS No. 1404-88-2）

Anti-infectives, including but not limited to 3,4',5-Tribromosalicylanilide （Tribromsalan （INN） ）（CAS No. 87-10-5）, Antibiotics, Dihydrotachysterol （INN） （CAS No. 67-96-9）, Ethionamide （INN） （CAS No. 536-33-4）, Furazolidone （INN） （CAS No. 67-45-8）, Ketoco

The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.

All China recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.
Conditions and restrictions
Prohibited in cosmetic product formulas. Verify the cited Chinese source identity and any later NMPA amendment before use.

Substance identity

Official source name
抗感染类药物，包括但不限于三溴沙 仑、抗生素类、二氢速甾醇、乙硫异烟 胺、呋喃唑酮、酮康唑、甲硝唑、呋喃 妥因、磺胺类药物（磺胺和其氨基的一 个或多个氢原子被取代的衍生物）及其 盐类、甲巯咪唑、短杆菌素等 — Anti-infectives, including but not limited to 3,4',5-Tribromosalicylanilide （Tribromsalan （INN） ）（CAS No. 87-10-5）, Antibiotics, Dihydrotachysterol （INN） （CAS No. 67-96-9）, Ethionamide （INN） （CAS No. 536-33-4）, Furazolidone （INN） （CAS No. 67-45-8）, Ketoconazole （CAS No. 65277-42-1）, Metronidazole （CAS No. 443-48-1）, Nitrofurantoin （INN） （CAS No. 67-20-9）, Sulphonamides （sulphanilamide and its derivatives obtained by substitution of one or more H-atoms of the -NH2 groups） and their salts, Thiamazole （INN） （CAS No. 60-56-0）, Thyrothricine （CAS No. 1404-88-2）
CAS
87-10-5; 67-96-9; 536-33-4; 67-45-8; 65277-42-1; 443-48-1; 67-20-9; 60-56-0; 1404-88-2
EC
Not supplied in this source row
Identity mapping
Exact CAS: 65277-42-1
Linked ingredient
KETOCONAZOLE
Search this identity across the siteCAS 87-10-5CAS 67-96-9CAS 536-33-4CAS 67-45-8CAS 65277-42-1CAS 443-48-1CAS 67-20-9CAS 60-56-0CAS 1404-88-2

Linked CosIng identity data

Names and aliases

KETOCONAZOLE

CosIng description: Ketoconazole is the heterocyclic compound that conforms to the formula

EU inventory restriction note: II/1528

Recorded cosmetic function: NOT REPORTED

Function pages:NOT REPORTED

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 1404-88-2
CAS 1404-88-2PubChem CID 452550

Verified chemistry for CAS 1404-88-2

Tyrothricin

IUPAC name
3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-amino-2-oxoethyl)-9-(3-aminopropyl)-3,22,25-tribenzyl-15-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)-2,5,8,11,14,18,21,24,27-nonaoxo-12-propan-2-yl-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propanoic acid
Molecular formula
C65H85N11O13
Molecular weight
1228.4 g/mol
Exact mass
1227.63283181 Da
Monoisotopic mass
1227.63283181 Da
XLogP3
1.9
Topological polar surface area
380.0 Ų
Molecular complexity
2390.0
Formal charge
0
Hydrogen-bond donors
12
Hydrogen-bond acceptors
15
Rotatable bonds
19
Heavy atoms
89
Covalent units
1

Names and synonyms reported to PubChem

BactratycinColtirotDermotricineHydrotricineMartricinTirotricinaTyrothricineSolutricine
16 more reported names
TyrothricinumTyrodermTyrosurDubos crude crystalsTyri 10NSC-757363RefChem:192767D06AX08R02AB02S01AA05215-771-0PharothricettenBiothricinGinotricinaRinotricinaTriciderm
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
10
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](C(=O)[C@@H](NC(=O)[C@@H](N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN)C(C)C)CC3=CC=C(C=C3)O)CCC(=O)O)CC(=O)N)CC4=CC=CC=C4)CC5=CC=CC=C5)CC6=CC=CC=C6
InChI
InChI=1S/C65H85N11O13/c1-38(2)32-49-60(84)74-52(36-42-20-12-7-13-21-42)65(89)76-31-15-23-53(76)63(87)73-51(34-41-18-10-6-11-19-41)61(85)70-47(33-40-16-8-5-9-17-40)57(81)48(37-54(67)78)71-59(83)46(28-29-55(79)80)68-50(35-43-24-26-44(77)27-25-43)62(86)75-56(39(3)4)64(88)69-45(22-14-30-66)58(82)72-49/h5-13,16-21,24-27,38-39,45-53,56,68,77H,14-15,22-23,28-37,66H2,1-4H3,(H2,67,78)(H,69,88)(H,70,85)(H,71,83)(H,72,82)(H,73,87)(H,74,84)(H,75,86)(H,79,80)/t45-,46-,47+,48-,49-,50-,51-,52+,53-,56-/m0/s1
InChIKey
NLJVXZFCYKWXLH-DXTIXLATSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 443-48-1
CAS 443-48-1PubChem CID 4173

Verified chemistry for CAS 443-48-1

Metronidazole

IUPAC name
2-(2-methyl-5-nitroimidazol-1-yl)ethanol
Molecular formula
C6H9N3O3
Molecular weight
171.15 g/mol
Exact mass
171.06439116 Da
Monoisotopic mass
171.06439116 Da
XLogP3
0.0
Topological polar surface area
83.9 Ų
Molecular complexity
170.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
4
Rotatable bonds
2
Heavy atoms
12
Covalent units
1

Names and synonyms reported to PubChem

MetronidazolGineflavir2-Methyl-5-nitroimidazole-1-ethanolDeflamonOrvagilTrichazolMetroGelSanatrichom
16 more reported names
AnagiardilDanizolMeronidalMetronidazMexibolTrichocideTricocetTrivazolVagilenVagimidArilinClontKlionBayer 5360MetronidazoloAcromona
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
7
3D rings
1
3D hydrophobes
0
3D acceptor features
3
3D donor features
1
3D anionic centres
1
3D cationic centres
1
3D conformers
2
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
CC1=NC=C(N1CCO)[N+](=O)[O-]
InChI
InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
InChIKey
VAOCPAMSLUNLGC-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 536-33-4
CAS 536-33-4PubChem CID 2761171

Verified chemistry for CAS 536-33-4

Ethionamide

Ethionamide is a thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide. It has a role as an antitubercular agent, an antilipemic drug, a leprostatic drug, a fatty acid synthesis inhibitor and a prodrug. It is a member of pyridines and a thiocarboxamide. — ChEBI

IUPAC name
2-ethylpyridine-4-carbothioamide
Molecular formula
C8H10N2S
Molecular weight
166.25 g/mol
Exact mass
166.05646950 Da
Monoisotopic mass
166.05646950 Da
XLogP3
1.1
Topological polar surface area
71.0 Ų
Molecular complexity
147.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Rotatable bonds
2
Heavy atoms
11
Covalent units
1

Names and synonyms reported to PubChem

TrecatorEthioniamideAmidazineEthinamideEthyonomideEtionamidEtioniamid2-Ethylthioisonicotinamide
16 more reported names
NizotinEthylisothiamideTeberusTrecator-SCAmidazinBayer 5312IridocinIridozinSertinonThianideTrescatylEtionid4-Pyridinecarbothioamide, 2-ethyl-EtionizinEtionizineEthimide
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
1
3D hydrophobes
1
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
2.0
Machine-readable structure identifiers
SMILES
CCC1=NC=CC(=C1)C(=S)N
InChI
InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)
InChIKey
AEOCXXJPGCBFJA-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 60-56-0
CAS 60-56-0PubChem CID 1349907

Verified chemistry for CAS 60-56-0

Methimazole

Methimazole is a member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen. It has a role as an antithyroid drug. — ChEBI

IUPAC name
3-methyl-1H-imidazole-2-thione
Molecular formula
C4H6N2S
Molecular weight
114.17 g/mol
Exact mass
114.02516937 Da
Monoisotopic mass
114.02516937 Da
XLogP3
-0.3
Topological polar surface area
47.4 Ų
Molecular complexity
119.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Rotatable bonds
0
Heavy atoms
7
Covalent units
1

Names and synonyms reported to PubChem

thiamazoleTapazole1-Methyl-1H-imidazole-2-thiolMethimazol1-Methylimidazole-2-thiolMercazolylThiamazolMercazole
16 more reported names
ThymidazolThymidazoleFavistanMercaptazoleMetothyrineMetazoloMetothyrinStrumazolThycapzolDanantizolFrentiroxMerkazolilMetotirinThacapzolBasolanMercasolyl
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
1
3D hydrophobes
0
3D acceptor features
1
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
0.0
Machine-readable structure identifiers
SMILES
CN1C=CNC1=S
InChI
InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
InChIKey
PMRYVIKBURPHAH-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 65277-42-1
CAS 65277-42-1PubChem CID 47576

Verified chemistry for CAS 65277-42-1

Ketoconazole

(2S,4R)-ketoconazole is a cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2S,4R)-configuration. It is an enantiomer of a (2R,4S)-ketoconazole. — ChEBI

IUPAC name
1-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
Molecular formula
C26H28Cl2N4O4
Molecular weight
531.4 g/mol
Exact mass
530.1487608 Da
Monoisotopic mass
530.1487608 Da
XLogP3
4.3
Topological polar surface area
69.1 Ų
Molecular complexity
735.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
6
Rotatable bonds
7
Heavy atoms
36
Covalent units
1

Names and synonyms reported to PubChem

NizoralPanfungolKetodermFungarestFungoralKetoisdinKetozoleExtina
16 more reported names
Orifungal MNizoral a-DKetoconazolXolegelKetoconazolumPiperazine, 1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, cis-R 41400R9400W927ICHEBI:47519Piperazine, 1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-, cis-R-41400DandrazolDandridKetopineNizorelle(+-)-cis-1-Acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
2
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
11
3D rings
5
3D hydrophobes
0
3D acceptor features
4
3D donor features
0
3D anionic centres
0
3D cationic centres
2
3D conformers
10
Effective 3D rotors
10.2
Machine-readable structure identifiers
SMILES
CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@@H]3CO[C@@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
InChI
InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
InChIKey
XMAYWYJOQHXEEK-ZEQKJWHPSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 67-20-9
CAS 67-20-9PubChem CID 6604200

Verified chemistry for CAS 67-20-9

Nitrofurantoin

Nitrofurantoin is an imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA. It has a role as an antiinfective agent, an antibacterial drug and a hepatotoxic agent. It is an imidazolidine-2,4-dione, an organonitrogen heterocyclic antibiotic, an organooxygen heterocyclic antibiotic and a nitrofuran antibiotic. It is functionally related to a semicarbazide. — ChEBI

IUPAC name
1-[(E)-(5-nitrofuran-2-yl)methylideneamino]imidazolidine-2,4-dione
Molecular formula
C8H6N4O5
Molecular weight
238.16 g/mol
Exact mass
238.03381930 Da
Monoisotopic mass
238.03381930 Da
XLogP3
-0.5
Topological polar surface area
121.0 Ų
Molecular complexity
390.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
6
Rotatable bonds
2
Heavy atoms
17
Covalent units
1

Names and synonyms reported to PubChem

FuradantinMacrodantin5-NitrofurantoinFuradantoinFuradoninFuradontinNifurantinFuralan
16 more reported names
MacrobidOrafuranParfuranUrantoinIturanNitrofurantoinaNitrofurantoineBerkfurinChemiofuranFurachelFuradoineFuradonineFuratoinFurobactinaNovofuranTrantoin
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
1
Undefined bond stereocentres
0
3D pharmacophore features
10
3D rings
2
3D hydrophobes
0
3D acceptor features
6
3D donor features
1
3D anionic centres
1
3D cationic centres
0
3D conformers
10
Effective 3D rotors
3.6
Machine-readable structure identifiers
SMILES
C1C(=O)NC(=O)N1/N=C/C2=CC=C(O2)[N+](=O)[O-]
InChI
InChI=1S/C8H6N4O5/c13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16/h1-3H,4H2,(H,10,13,14)/b9-3+
InChIKey
NXFQHRVNIOXGAQ-YCRREMRBSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 67-45-8
CAS 67-45-8PubChem CID 5323714

Verified chemistry for CAS 67-45-8

Furazolidone

Furazolidone is a member of the class of oxazolidines that is 1,3-oxazolidin-2-one in which the hydrogen attached to the nitrogen is replaced by an N-{[(5-nitro-2-furyl)methylene]amino} group. It has antibacterial and antiprotozoal properties, and is used in the treatment of giardiasis and cholera. It has a role as an antiinfective agent, an antibacterial drug, an EC 1.4.3.4 (monoamine oxidase) inhibitor and an antitrichomonal drug. It is a member of oxazolidines and a nitrofuran antibiotic. — ChEBI

IUPAC name
3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one
Molecular formula
C8H7N3O5
Molecular weight
225.16 g/mol
Exact mass
225.03857033 Da
Monoisotopic mass
225.03857033 Da
XLogP3
-0.1
Topological polar surface area
101.0 Ų
Molecular complexity
326.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
6
Rotatable bonds
2
Heavy atoms
16
Covalent units
1

Names and synonyms reported to PubChem

FuroxoneNitrofurazolidoneFurazolidineNitrofuroxonDiafuronFurazolFuridonNeftin
16 more reported names
FuraxoneFurazolidonFuroxaneNifulidoneFurazonFuroxonGiarlamNitrofurazolidonumFurozolidineNifurazolidoneTikofuranTrichofuronTricofuronCoryziumFuraxonFuroxal
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
1
Undefined bond stereocentres
0
3D pharmacophore features
8
3D rings
2
3D hydrophobes
0
3D acceptor features
5
3D donor features
0
3D anionic centres
1
3D cationic centres
0
3D conformers
6
Effective 3D rotors
3.8
Machine-readable structure identifiers
SMILES
C1COC(=O)N1/N=C/C2=CC=C(O2)[N+](=O)[O-]
InChI
InChI=1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+
InChIKey
PLHJDBGFXBMTGZ-WEVVVXLNSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 67-96-9
CAS 67-96-9PubChem CID 5311071

Verified chemistry for CAS 67-96-9

Dihydrotachysterol

Dihydrotachysterol is a hydroxy seco-steroid that is 9,10-secoergosta-5,7,22-triene substituted by a hydroxy group at position 3. A synthetic analogue of vitamin D that acts a bone density conservation agent. It has a role as a bone density conservation agent. It is a vitamin D, a seco-ergostane and a hydroxy seco-steroid. — ChEBI

IUPAC name
trans-(1S,3E,4S)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylcyclohexan-1-ol
Molecular formula
C28H46O
Molecular weight
398.7 g/mol
Exact mass
398.354866087 Da
Monoisotopic mass
398.354866087 Da
XLogP3
7.7
Topological polar surface area
20.2 Ų
Molecular complexity
639.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Rotatable bonds
5
Heavy atoms
29
Covalent units
1

Names and synonyms reported to PubChem

DichystrolumAntitanilHytakerolTachystinDihidrotaquisterolDihydrotachysterol2DihydralDygratyl
16 more reported names
ParterolTachyrolAnti-tetany substance 10DihydrotachysterolumDHT2DiidrotachisteroloDihydrotachysterol 2AT 10Tachysterol, dihydro-Tachysterol2, dihydro-A.T. 10R5LM3H112RTachysterol dihydro derivativeCHEBI:45919,10-Secoergosta-5,7,22-trien-3beta-ol(1S,3E,4S)-3-{2-[(1R,3aS,4E,7aR)-1-[(2R,3E,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylcyclohexan-1-ol
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
7
Undefined atom stereocentres
0
Defined bond stereocentres
3
Undefined bond stereocentres
0
3D pharmacophore features
8
3D rings
3
3D hydrophobes
3
3D acceptor features
1
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
10
Effective 3D rotors
7.2
Machine-readable structure identifiers
SMILES
C[C@H]\1CC[C@@H](C/C1=C\C=C\2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)/C=C/[C@H](C)C(C)C)C)O
InChI
InChI=1S/C28H46O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-22,25-27,29H,7-8,11,14-18H2,1-6H3/b10-9+,23-12+,24-13+/t20-,21-,22+,25-,26+,27-,28+/m0/s1
InChIKey
ILYCWAKSDCYMBB-OPCMSESCSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 87-10-5
CAS 87-10-5PubChem CID 14868

Verified chemistry for CAS 87-10-5

3,4',5-Tribromosalicylanilide

IUPAC name
3,5-dibromo-N-(4-bromophenyl)-2-hydroxybenzamide
Molecular formula
C13H8Br3NO2
Molecular weight
449.92 g/mol
Exact mass
448.80847 Da
Monoisotopic mass
446.81052 Da
XLogP3
5.0
Topological polar surface area
49.3 Ų
Molecular complexity
321.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Rotatable bonds
2
Heavy atoms
19
Covalent units
1

Names and synonyms reported to PubChem

TribromsalanTemasept IVTrisanilTuasol 100ET-394NSC-205266MCE3VTF0OSalicylanilide, 3,4',5-tribromo-
16 more reported names
BENZAMIDE, 3,5-DIBROMO-N-(4-BROMOPHENYL)-2-HYDROXY-WR-34912CHEBI:127105DiapheneTemaceptRefChem:899088201-723-63,5,4'-TribromosalicylanilideAgramedTRIBROMOSALICYLANILIDETemasept IITrisanylTempasept IISherstat TBSVancide TBSTribromsalanum
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
8
3D rings
2
3D hydrophobes
3
3D acceptor features
1
3D donor features
2
3D anionic centres
0
3D cationic centres
0
3D conformers
5
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1NC(=O)C2=C(C(=CC(=C2)Br)Br)O)Br
InChI
InChI=1S/C13H8Br3NO2/c14-7-1-3-9(4-2-7)17-13(19)10-5-8(15)6-11(16)12(10)18/h1-6,18H,(H,17,19)
InChIKey
KVSKGMLNBAPGKH-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
China NMPA banned raw-material catalogues (2021)
Source reference
NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 299
Source record ID
chemical-299
Source version
NMPA Announcement No. 74 of 2021, effective 2021-05-26
Source language
Chinese with source English/Latin identity
Translation status
Official English translation · English translation
Effective date
2021-05-26
Source updated
2021-05-26
Snapshot checked
2026-08-31 14:13 UTC
Validation method
pdfplumber tables; exact 1,284 + 109 row counts and contiguous source numbering
SHA-256
8848aa3e0c7ac5e74f56fc27927336c4fc2e5bc80137da087c2ca9ba2d2c075e

Registered dataset notes

Dataset coverage
All 1,284 banned raw materials and 109 banned plant/animal raw materials effective from 26 May 2021
Authority note
Binding NMPA catalogues replacing Tables 1 and 2 of the 2015 Technical Specification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1393
current China records
1393
records marked Prohibited
1393
records from this source version
1249
market records with CAS identity

Status distribution

Prohibited: 1393

Condition text is present on 1393 of 1393 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

China market context

Complete prohibited catalogues plus official-source workflow

Coverage version: NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025

All 1,284 banned raw materials and 109 banned plant/animal raw materials, plus the official workflow for the dynamic existing-ingredient inventory, other technical restrictions and new ingredients.

Verification checklist

  1. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  2. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  3. Review technical purpose, use history and any monitoring period.
  4. Confirm Chinese labelling, safety assessment and filing/registration duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “抗感染类药物，包括但不限于三溴沙 仑、抗生素类、二氢速甾醇、乙硫异烟 胺、呋喃唑酮、酮康唑、甲硝唑、呋喃 妥因、磺胺类药物（磺胺和其氨基的一 个或多个氢原子被取代的衍生物）及其 盐类、甲巯咪唑、短杆菌素等 — Anti-infectives, including but not limited to 3,4',5-Tribromosalicylanilide （Tribromsalan （INN） ）（CAS No. 87-10-5）, Antibiotics, Dihydrotachysterol （INN） （CAS No. 67-96-9）, Ethionamide （INN） （CAS No. 536-33-4）, Furazolidone （INN） （CAS No. 67-45-8）, Ketoconazole （CAS No. 65277-42-1）, Metronidazole （CAS No. 443-48-1）, Nitrofurantoin （INN） （CAS No. 67-20-9）, Sulphonamides （sulphanilamide and its derivatives obtained by substitution of one or more H-atoms of the -NH2 groups） and their salts, Thiamazole （INN） （CAS No. 60-56-0）, Thyrothricine （CAS No. 1404-88-2）” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  3. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  4. Review technical purpose, use history and any monitoring period.
  5. Confirm Chinese labelling, safety assessment and filing/registration duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

The record cites NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 299, source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

抗感染类药物，包括但不限于三溴沙 仑、抗生素类、二氢速甾醇、乙硫异烟 胺、呋喃唑酮、酮康唑、甲硝唑、呋喃 妥因、磺胺类药物（磺胺和其氨基的一 个或多个氢原子被取代的衍生物）及其 盐类、甲巯咪唑、短杆菌素等 — Anti-infectives, including but not limited to 3,4',5-Tribromosalicylanilide （Tribromsalan （INN） ）（CAS No. 87-10-5）, Antibiotics, Dihydrotachysterol （INN） （CAS No. 67-96-9）, Ethionamide （INN） （CAS No. 536-33-4）, Furazolidone （INN） （CAS No. 67-45-8）, Ketoconazole （CAS No. 65277-42-1）, Metronidazole （CAS No. 443-48-1）, Nitrofurantoin （INN） （CAS No. 67-20-9）, Sulphonamides （sulphanilamide and its derivatives obtained by substitution of one or more H-atoms of the -NH2 groups） and their salts, Thiamazole （INN） （CAS No. 60-56-0）, Thyrothricine （CAS No. 1404-88-2）. NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 299. China. Source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. CosIng Checker regulatory record: https://cosingchecker.com/regulations/cn/records/11988/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for China

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: NMPA Announcement No. 74 of 2021, effective 2021-05-26
  • Effective date: 2021-05-26

What it does not prove

IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source