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InventoryRef cosing-live-1051642024-08-26

KETOCONAZOLE

Ketoconazole is the heterocyclic compound that conforms to the formula

KETOCONAZOLE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet. Inventory note: II/1528.

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Regulatory evidence by market

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MarketEvidence statusRecordsSource language
European UnionSource mapped
Inventory entry; no linked annex rule
0English and EU languages
Great BritainEvidence linked
Prohibited
Open this evidence		1English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandEvidence linked
Prohibited
Open this evidence		1English
ASEANEvidence linked
Prohibited
Open this evidence		1English and national languages
ChinaEvidence linked
Prohibited
Open this evidence		1Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaEvidence linked
Prohibited
Open this evidence		1Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilEvidence linked
Prohibited
Open this evidence		1Portuguese with INCI crosswalks
IndiaEvidence linked
Prohibited
Open this evidence		1English and Hindi
Saudi ArabiaEvidence linked
Prohibited
Open this evidence		1Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 65277-42-1
CAS 65277-42-1PubChem CID 47576

Ketoconazole

(2S,4R)-ketoconazole is a cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2S,4R)-configuration. It is an enantiomer of a (2R,4S)-ketoconazole. — ChEBI

IUPAC name
1-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
Molecular formula
C26H28Cl2N4O4
Molecular weight
531.4 g/mol
Exact mass
530.1487608 Da
XLogP3
4.3
Topological polar surface area
69.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
2

Also known as

NizoralPanfungolKetodermFungarestFungoralKetoisdinKetozoleExtina
16 more reported names
Orifungal MNizoral a-DKetoconazolXolegelKetoconazolumPiperazine, 1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, cis-R 41400R9400W927ICHEBI:47519Piperazine, 1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-, cis-R-41400DandrazolDandridKetopineNizorelle(+-)-cis-1-Acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID
105164
Entry status
Active
Published in the Official Journal
Yes
Recorded by the Commission
2024-08-26
Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for KETOCONAZOLE

INCI name

KETOCONAZOLE

Description

Ketoconazole is the heterocyclic compound that conforms to the formula

Record provenance

Inventory reference
cosing-live-105164
Imported identity
KETOCONAZOLE
Source update
2024-08-26
European Commission CosIng source notes
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Key data

CAS
65277-42-1
EC
265-667-4
Restriction
II/1528
Function
NOT REPORTED
No function currently reported.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#14153 · KETOCONAZOLE

Ingredients with overlapping formulation functions

ISOPROPYL MALEATENOT REPORTED
ISOPROPYLACRYLAMIDENOT REPORTED
ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHERNOT REPORTED
JAPANESE PUFFERFISH SKIN EXTRACTNOT REPORTED
LACTIC YEASTSNOT REPORTED
LACTOBACILLUS/COFFEA CANEPHORA SEED FERMENT FILTRATENOT REPORTED
LACTOBACILLUS/GLYCERIN/HYDROLYZED CASEIN/LACTOSE/CATHARANTHUS ROSEUS SEED/YEAST…NOT REPORTED
LACTOBACILLUS/LAC/CALCIUM/PHOSPHORUS/MAGNESIUM/ZINC FERMENTNOT REPORTED

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How KETOCONAZOLE appears in the CosIng inventory

The CosIng inventory lists KETOCONAZOLE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

KETOCONAZOLE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

KETOCONAZOLE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

The restriction field for KETOCONAZOLE reads: "II/1528". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, KETOCONAZOLE carries the following function designation(s):

CAS 65277-42-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for KETOCONAZOLE

This page reproduces the CosIng inventory entry for KETOCONAZOLE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research KETOCONAZOLE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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