KETOCONAZOLE
Ketoconazole is the heterocyclic compound that conforms to the formula
KETOCONAZOLE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet. Inventory note: II/1528.
Regulatory evidence by market
This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.
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| Market | Evidence status | Records | Source language |
|---|---|---|---|
| European Union | Source mapped Inventory entry; no linked annex rule | 0 | English and EU languages |
| Great Britain | Evidence linked Prohibited Open this evidence | 1 | English |
| Canada | Source mapped Official source mapped; ingredient rule not imported | 0 | English and French |
| New Zealand | Evidence linked Prohibited Open this evidence | 1 | English |
| ASEAN | Evidence linked Prohibited Open this evidence | 1 | English and national languages |
| China | Evidence linked Prohibited Open this evidence | 1 | Chinese with selected English material |
| Japan | Source mapped Official source mapped; ingredient rule not imported | 0 | Japanese; official English translation available |
| South Korea | Evidence linked Prohibited Open this evidence | 1 | Korean with some English names |
| United States | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Australia | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Brazil | Evidence linked Prohibited Open this evidence | 1 | Portuguese with INCI crosswalks |
| India | Evidence linked Prohibited Open this evidence | 1 | English and Hindi |
| Saudi Arabia | Evidence linked Prohibited Open this evidence | 1 | Arabic and English |
Chemical identity and properties
Ketoconazole
(2S,4R)-ketoconazole is a cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2S,4R)-configuration. It is an enantiomer of a (2R,4S)-ketoconazole. — ChEBI
- IUPAC name
- 1-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
- Molecular formula
- C26H28Cl2N4O4
- Molecular weight
- 531.4 g/mol
- Exact mass
- 530.1487608 Da
- XLogP3
- 4.3
- Topological polar surface area
- 69.1 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 6
- Covalent units
- 1
- Defined stereocentres
- 2
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:47518
- ChEMBL:CHEMBL295698
- EPA DTXSID:DTXSID60161949
- PubMed:40976440
- PubMed:38795739
- PubMed:38734219
- PubMed:37788138
- PubMed:37077353
- PubMed:36893891
- PubMed:36653537
- PubMed:36621641
- PubMed:36374910
- PubMed:36332690
- PubMed:35478211
- PubMed:35358606
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for KETOCONAZOLE
INCI name
KETOCONAZOLE
Description
Ketoconazole is the heterocyclic compound that conforms to the formula
Record provenance
- Inventory reference
- cosing-live-105164
- Imported identity
- KETOCONAZOLE
- Source update
- 2024-08-26
Annex records for KETOCONAZOLE
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
An exact glossary-name match supports label identity; it does not by itself mean that an ingredient is permitted, safe for every use, or free from annex restrictions. Check the regulatory evidence above.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
Use identifiers from this page to verify chemical identity, hazard context and market-surveillance evidence. These sources add context; they do not replace the applicable cosmetics law.
ECHA CHEM / Information on chemicals
Use as CAS/EC enrichment for REACH/CLP hazard and regulatory status. Treat as targeted enrichment, not simple bulk import.
Open source sitePubChem PUG REST
Use name/CAS lookup to add CID, molecular formula, molecular weight, InChIKey and canonical SMILES.
Lookup identity: 65277-42-1
Open identifier lookupEU Safety Gate cosmetic product alerts
Published cosmetic product alerts, notifying country, risk, product identifiers and corrective measures
Open source siteECHA CHEM
EU substance information, REACH context and CLP classification where available.
Open source siteCosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Open source siteFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Open source siteILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
Open source siteJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Open source siteNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
Open source siteOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Open source siteHow KETOCONAZOLE appears in the CosIng inventory
The CosIng inventory lists KETOCONAZOLE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
KETOCONAZOLE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for KETOCONAZOLE
This page reproduces the CosIng inventory entry for KETOCONAZOLE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research KETOCONAZOLE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
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