Tyrothricin
Tyrothricin is an antibiotic peptide complex produced and extracted from the aerobic Gram-positive bacillus Brevibacillus parabrevis which was previously categorized as Bacillus brevis and Bacillus aneurinolyticus. This complex is a mixture comprised of 60% tyrocidine cationic cyclic decapeptides (consisting largely of the six predominant tyrocidines, TrcA/A1, TrcB/B1, TrcC/C1, and other more minor contributors) and 40% neutral linear gramicidins (where valine-gramicidin A is often the major gramicidin present, although the mixture composition can vary). Moreover, tyrothricin possesses broad spectrum Gram-positive antibacterial and antifungal activity that has not seen many - if any - significant reportings of microbial resistance during the over 60 years of therapeutic use the complex has provided. Nevertheless, as tyrothricin is both cytolytic and hemolytic, it does demonstrate systemic toxicity, although certain formulations that are safe for human use like throat lozenges do exist. — DrugBank
- IUPAC name
- 3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-amino-2-oxoethyl)-9-(3-aminopropyl)-3,22,25-tribenzyl-15-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)-2,5,8,11,14,18,21,24,27-nonaoxo-12-propan-2-yl-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propanoic acid
- Molecular formula
- C65H85N11O13
- Molecular weight
- 1228.4 g/mol
- Exact mass
- 1227.63283181 Da
- XLogP3
- 1.9
- Topological polar surface area
- 380.0 Ų
- Hydrogen-bond donors
- 12
- Hydrogen-bond acceptors
- 15
- Covalent units
- 1
- Defined stereocentres
- 10
Also known as
16 more reported names
External database identifiers
- ChEMBL:CHEMBL577736
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.