Why does CAS 536-33-4 appear in more than one EU cosmetic annex?

A substance identified by CAS 536-33-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 536-33-4?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 536-33-4 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 536-33-4

Q: How do I use CAS 536-33-4 for compliance screening?

Cross-reference CAS 536-33-4 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 536-33-4 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 536-33-4

CAS 536-33-4PubChem CID 2761171

Ethionamide

Ethionamide is a thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide. It has a role as an antitubercular agent, an antilipemic drug, a leprostatic drug, a fatty acid synthesis inhibitor and a prodrug. It is a member of pyridines and a thiocarboxamide. — ChEBI

IUPAC name: 2-ethylpyridine-4-carbothioamide

Molecular formula: C8H10N2S
Molecular weight: 166.25 g/mol
Exact mass: 166.05646950 Da
XLogP3: 1.1
Topological polar surface area: 71.0 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

TrecatorEthioniamideAmidazineEthinamideEthyonomideEtionamidEtioniamid2-Ethylthioisonicotinamide

16 more reported names

NizotinEthylisothiamideTeberusTrecator-SCAmidazinBayer 5312IridocinIridozinSertinonThianideTrescatylEtionid4-Pyridinecarbothioamide, 2-ethyl-EtionizinEtionizineEthimide

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:4885
ChEMBL:CHEMBL1441
EPA DTXSID:DTXSID0020577
PubMed:33814510
PubMed:32808185
PubMed:26708503
PubMed:26062974
PubMed:25051504
PubMed:23112434
PubMed:23107633
PubMed:23106273
PubMed:23020577
PubMed:23019444
PubMed:22952439
PubMed:22904807

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 536-33-4

1 total

Annex

Entry

319

Ethionamide (INN)

208-628-9

How CAS 536-33-4 is used on this site

CAS 536-33-4 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 536-33-4 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 536-33-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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