Why does CAS 67-20-9 appear in more than one EU cosmetic annex?

A substance identified by CAS 67-20-9 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 67-20-9?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 67-20-9 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 67-20-9

Q: How do I use CAS 67-20-9 for compliance screening?

Cross-reference CAS 67-20-9 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 67-20-9 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 67-20-9

CAS 67-20-9PubChem CID 6604200

Nitrofurantoin

Nitrofurantoin is an imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA. It has a role as an antiinfective agent, an antibacterial drug and a hepatotoxic agent. It is an imidazolidine-2,4-dione, an organonitrogen heterocyclic antibiotic, an organooxygen heterocyclic antibiotic and a nitrofuran antibiotic. It is functionally related to a semicarbazide. — ChEBI

IUPAC name: 1-[(E)-(5-nitrofuran-2-yl)methylideneamino]imidazolidine-2,4-dione

Molecular formula: C8H6N4O5
Molecular weight: 238.16 g/mol
Exact mass: 238.03381930 Da
XLogP3: -0.5
Topological polar surface area: 121.0 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 0

Also known as

FuradantinMacrodantin5-NitrofurantoinFuradantoinFuradoninFuradontinNifurantinFuralan

16 more reported names

MacrobidOrafuranParfuranUrantoinIturanNitrofurantoinaNitrofurantoineBerkfurinChemiofuranFurachelFuradoineFuradonineFuratoinFurobactinaNovofuranTrantoin

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:71415
ChEBI:CHEBI:95222
ChEMBL:CHEMBL572
PubMed:35278701
PubMed:29271734
PubMed:28600080
PubMed:19525487
PubMed:15962942
PubMed:11434731
PubMed:11102410
PubMed:10464017
PubMed:7928834
PubMed:7226713
PubMed:7085535
PubMed:6626697

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 67-20-9

1 total

Annex

Entry

251

Nitrofurantoin (INN)

200-646-5

How CAS 67-20-9 is used on this site

CAS 67-20-9 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 67-20-9 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 67-20-9 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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