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Annex V Entry 42 16/10/2010

CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE

N,N'-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine and its digluconate, diacetate and dihydrochloride

CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: 0.3% (as chlorhexidine).

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Permitted preservative— Annex V, EU Regulation 1223/2009
Max conc.: 0.3% (as chlorhexidine)
Entry: 42

Chemical identity and properties

PubChem 2D chemical structure for CAS 18472-51-0
CAS 18472-51-0PubChem CID 9552081

Chlorhexidine Gluconate

Chlorhexidine gluconate is a D-gluconate adduct and an organochlorine compound. It has a role as an antibacterial agent. It is functionally related to a chlorhexidine. — ChEBI

IUPAC name
(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid)
Molecular formula
C34H54Cl2N10O14
Molecular weight
897.8 g/mol
Exact mass
896.3198018 Da
Topological polar surface area
454.0 Ų
Hydrogen-bond donors
18
Hydrogen-bond acceptors
16
Covalent units
3
Defined stereocentres
8

Also known as

CHLORHEXIDINE DIGLUCONATEHibiclensDyna-hexBioscrubHibistatMicrodermPeriochipPeriogard
16 more reported names
ExidineChlorhexidine D-digluconateBrian CareSteri-StatCida-StatBacticlensCorsodylHibidilKleersightPrevacarePharmaseal Scrub CareCHG SCRUBFight bacPrevacare RChlorhexidine di-D-gluconateMOR84MUD8E
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 3697-42-5
CAS 3697-42-5PubChem CID 9571016

Chlorhexidine Hydrochloride

Chlorhexidine hydrochloride is a member of guanidines. — ChEBI

IUPAC name
(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;dihydrochloride
Molecular formula
C22H32Cl4N10
Molecular weight
578.4 g/mol
Exact mass
578.153602 Da
Topological polar surface area
178.0 Ų
Hydrogen-bond donors
8
Hydrogen-bond acceptors
2
Covalent units
3
Defined stereocentres
0

Also known as

Chlorhexidine dihydrochlorideChlorhexidine HClDantroche hibitaneAY-5312E64XL9U38KNSC-7566792,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, dihydrochlorideChlorhex hcl
16 more reported names
1,1'-Hexamethylenebis(5-(4-chlorophenyl)biguanide) dihydrochloride1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] DihydrochlorideNolvasan Cap-TabsNolvasan SuspensionRefChem:54790Hydrochloride, Chlorhexidine223-026-6Chlorhexidine 2HClArlacide HCaswell No. 481FChlorhexidine (dihydrochloride)Chlorhexidinium dichloride1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) dihydrochlorideEINECS 223-026-6EPA Pesticide Chemical Code 481700UNII-E64XL9U38K
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 55-56-1
CAS 55-56-1PubChem CID 9552079

Chlorhexidine

Chlorhexidine is a bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. It has a role as an antibacterial agent and an antiinfective agent. It is a member of biguanides and a member of monochlorobenzenes. It is functionally related to a biguanide. — ChEBI

IUPAC name
(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine
Molecular formula
C22H30Cl2N10
Molecular weight
505.4 g/mol
Exact mass
504.2031964 Da
XLogP3
0.1
Topological polar surface area
178.0 Ų
Hydrogen-bond donors
6
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

HexadolSoretolFimeilSterilonTubulicidChlorhexidinumChlorhexidinClorhexidina
16 more reported names
CloresidinaNolvasanMerfen-incoloreChlorhexadineDentisept1,6-Bis(p-chlorophenyldiguanido)hexane1,6-Di(4'-chlorophenyldiguanido)hexane1,6-Bis(5-(p-chlorophenyl)biguandino)hexane1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide)R4KO0DY52LCHEBI:36141,6-Di(N-p-chlorophenyldiguanido)hexane2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-N,N'-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamideN-(4-chlorophenyl)-1-3-(6-{N-[3-(4-chlorophenyl)carbamimidamidomethanimidoyl]amino}hexyl)carbamimidamidomethanimidamideclorexidina
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 56-95-1
CAS 56-95-1PubChem CID 9562059

Chlorhexidine Acetate

Chlorhexidine acetate is the acetate salt of chlorhexidine. It is a disinfectant used for bacterial control in hospital, agricultural and domestic environments. It has a role as an antibacterial agent, an antiinfective agent, an antifungal agent and an antifouling biocide. It contains a chlorhexidine. — ChEBI

IUPAC name
acetic acid;(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine
Molecular formula
C26H38Cl2N10O4
Molecular weight
625.5 g/mol
Exact mass
624.2454551 Da
Topological polar surface area
252.0 Ų
Hydrogen-bond donors
8
Hydrogen-bond acceptors
6
Covalent units
3
Defined stereocentres
0

Also known as

Chlorhexidine diacetateHibitane diacetateChlorohexidine diacetate10,040 DiacetateChlorhexidini diacetas5908ZUF22YNSC-526936Chlorhexidine acetate (USP)
16 more reported names
Chlorhexidine acetate [USP]1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) diacetateCHEBI:81711SerdaenGout OintmentBacteriostatic gelNail fungus creamanti-bacterial gelAntibacterialTabletsNail Fungus LiquidNail Fungus SolutionAcetate, ChlorhexidineFROST-PROOFNolvasan Surgical ScrubHOQU Nail fungus creamDisinfectant Fabric Wash
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

0.3% (as chlorhexidine)

INCI glossary name

CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE

Chemical name

N,N'-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine and its digluconate, diacetate and dihydrochloride

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
55-56-1 / 56-95-1 / 18472-51-0 / 3697-42-5
EC
200-238-7 / 200-302-4 / 242-354-0 / 223-026-6
Annex
V
Entry number
42

Inventory links for CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE

Inventory Restriction reference
Ref 32657

CHLORHEXIDINE

CAS: 55-56-1
EC: 200-238-7

Direct matches are limited for this record, so nearby entries from Annex V are shown as well.

Annex V 38
Nearby record in the same annex

O-CYMEN-5-OL

CAS: 3228-02-2
EC: 221-761-7
Annex V 34
Nearby record in the same annex

BENZYL ALCOHOL

CAS: 100-51-6
EC: 202-859-9
Annex V 48
Nearby record in the same annex

GLUTARAL

CAS: 111-30-8
EC: 203-856-5
Annex V 33
Nearby record in the same annex

DMDM HYDANTOIN

CAS: 6440-58-0
EC: 229-222-8

What Annex V means for CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE

CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE is an approved preservative listed in Annex V of EU Cosmetics Regulation 1223/2009. Only substances on this positive list may be used as cosmetic preservatives in the EU.

Each preservative entry specifies maximum permitted concentrations and applicable product scope. Concentrations must not exceed the listed maximum. Some preservatives require warning statements on the product label.

This record is linked to 4 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Use concentration must not exceed: 0.3% (as chlorhexidine)
  • Verify the preservative is effective at the permitted concentration for your matrix.

Frequently asked questions

Yes. CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE is listed in Annex V of EU Cosmetics Regulation 1223/2009 as a permitted preservative. It may be used in cosmetics up to the maximum concentration specified above, within the permitted product scope.

CAS 55-56-1 / 56-95-1 / 18472-51-0 / 3697-42-5 is the unique numerical identifier assigned to CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 0.3% (as chlorhexidine) applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

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Source note for Annex V record CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE

This page summarizes one Annex V record for CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex V conditions for CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE, but confirm any final regulatory decision against the current official annex wording and source files.

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