What does the restriction note for CHLORHEXIDINE DIHYDROCHLORIDE mean?

The restriction field for CHLORHEXIDINE DIHYDROCHLORIDE reads: V/42. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 3697-42-5?

CAS 3697-42-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CHLORHEXIDINE DIHYDROCHLORIDE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3266010/08/2020

CHLORHEXIDINE DIHYDROCHLORIDE

N,N'-bis(4-Chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride

CHLORHEXIDINE DIHYDROCHLORIDE is linked to 1 EU annex record on this page. Inventory note: V/42.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Evidence linked Positive-list entry with conditions Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Permitted list with conditions Open this evidence	1	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Evidence linked Restricted Open this evidence	1	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 3697-42-5

CAS 3697-42-5PubChem CID 9571016

Chlorhexidine Hydrochloride

Chlorhexidine hydrochloride is a member of guanidines. — ChEBI

IUPAC name: (1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;dihydrochloride

Molecular formula: C22H32Cl4N10
Molecular weight: 578.4 g/mol
Exact mass: 578.153602 Da
Topological polar surface area: 178.0 Å²
Hydrogen-bond donors: 8
Hydrogen-bond acceptors: 2
Covalent units: 3
Defined stereocentres: 0

Also known as

Chlorhexidine dihydrochlorideChlorhexidine HClDantroche hibitaneAY-5312E64XL9U38KNSC-7566792,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, dihydrochlorideChlorhex hcl

16 more reported names

1,1'-Hexamethylenebis(5-(4-chlorophenyl)biguanide) dihydrochloride1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] DihydrochlorideNolvasan Cap-TabsNolvasan SuspensionRefChem:54790Hydrochloride, Chlorhexidine223-026-6Chlorhexidine 2HClArlacide HCaswell No. 481FChlorhexidine (dihydrochloride)Chlorhexidinium dichloride1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) dihydrochlorideEINECS 223-026-6EPA Pesticide Chemical Code 481700UNII-E64XL9U38K

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:31393
ChEMBL:CHEMBL1484251
EPA DTXSID:DTXSID7047144

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CHLORHEXIDINE DIHYDROCHLORIDE

INCI name

CHLORHEXIDINE DIHYDROCHLORIDE

INN name

chlorhexidine hydrochloride

Ph. Eur. name

chlorhexidini hydrochloridum

Description

N,N'-bis(4-Chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride

Record provenance

Inventory reference: 32660
Imported identity: CHLORHEXIDINE DIHYDROCHLORIDE
Source update: 10/08/2020

European Commission CosIng source notes

Annex records for CHLORHEXIDINE DIHYDROCHLORIDE

Annex V Restriction reference

Entry 42

CHLORHEXIDINE / CHLORHEXIDINE DIACETATE / CHLORHEXIDINE DIGLUCONATE / CHLORHEXIDINE DIHYDROCHLORIDE

CAS: 55-56-1 / 56-95-1 / 18472-51-0 / 3697-42-5

EC: 200-238-7 / 200-302-4 / 242-354-0 / 223-026-6

Key data

CAS

3697-42-5

223-026-6

Restriction

V/42

Function

ANTIMICROBIAL: Preventing and/or slowing down microbial growth.
ORAL CARE: Providing cosmetic effects to the oral cavity, e.g. cleansing, deodorising, protecting.
PRESERVATIVE: Exclusively or mainly intended to inhibit the development of micro-organisms in the cosmetic product. All authorised preservatives are substances in the positive list of Annex V to the Cosmetics Regulation 1223/2009.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#6214 · CHLORHEXIDINE DIHYDROCHLORIDE

The 3 markets that hold a rule for this substance do not classify it the same way.

restricted: Japan
permitted on a positive list: European Union New Zealand

See every substance the markets disagree about

Ingredients with overlapping formulation functions

CETRIMONIUM CHLORIDEANTIMICROBIAL, ANTISTATIC, PRESERVATIVE, SURFACTANT - EMULSIFYING

CHLORHEXIDINEANTIMICROBIAL, ORAL CARE, PRESERVATIVE

CHLORHEXIDINE DIACETATEANTIMICROBIAL, ORAL CARE, PRESERVATIVE

CHLORHEXIDINE DIGLUCONATEANTIMICROBIAL, ORAL CARE, PRESERVATIVE

CHLOROACETAMIDEPRESERVATIVE

CHLOROBUTANOLPRESERVATIVE

CHLOROPHENEANTIMICROBIAL, PRESERVATIVE

CHLOROXYLENOLANTIMICROBIAL, DEODORANT, PRESERVATIVE

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CHLORHEXIDINE DIHYDROCHLORIDE appears in the CosIng inventory

The CosIng inventory lists CHLORHEXIDINE DIHYDROCHLORIDE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CHLORHEXIDINE DIHYDROCHLORIDE is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CHLORHEXIDINE DIHYDROCHLORIDE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for CHLORHEXIDINE DIHYDROCHLORIDE reads: "V/42". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, CHLORHEXIDINE DIHYDROCHLORIDE carries the following function designation(s):

CAS 3697-42-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CHLORHEXIDINE DIHYDROCHLORIDE

This page combines the CosIng inventory entry for CHLORHEXIDINE DIHYDROCHLORIDE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research CHLORHEXIDINE DIHYDROCHLORIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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