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Annex V Entry 26 16/10/2010

CHLOROXYLENOL

Chloroxylenol

CHLOROXYLENOL appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: 0.5%.

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Permitted preservative— Annex V, EU Regulation 1223/2009
Max conc.: 0.5%
Entry: 26

Chemical identity and properties

PubChem 2D chemical structure for CAS 1321-23-9
CAS 1321-23-9PubChem CID 74075

Phenol, chlorodimethyl-

IUPAC name
4-chloro-2,3-dimethylphenol
Molecular formula
C8H9ClO
Molecular weight
156.61 g/mol
Exact mass
156.0341926 Da
XLogP3
2.2
Topological polar surface area
20.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

RefChem:8613211570-76-94-Chloro-2,3-xylenolChlorodimethylhydroxybenzenePhenol, 4-chloro-2,3-dimethyl-2,3-Xylenol, 4-chloro-NSC-60150Xylenol, chloro-
11 more reported names
2,3-dimethyl-4-chlorophenol4-chloro-2,3-dimethyl-phenolEINECS 215-316-6NSC 601503-methyl-4-chlorocresol4-chloro-3-methylcresolCFS3B2E4N4WZG0278DB-153722CS-0191115InChI=1/C8H9ClO/c1-5-6(2)8(10)4-3-7(5)9/h3-4,10H,1-2H
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 88-04-0
CAS 88-04-0PubChem CID 2723

4-Chloro-3,5-dimethylphenol

4-chloro-3,5-dimethylphenol is a member of the class of phenols that is 3,5-xylenol which is substituted at position 4 by chlorine. It is bactericidal against most Gram-positive bacteria but less effective against Staphylococci and Gram-negative bacteria, and often inactive against Pseudomonas species. It is ineffective against bacterial spores. It has a role as a molluscicide, an antiseptic drug and a disinfectant. It is a member of phenols and a member of monochlorobenzenes. It is functionally related to a 3,5-xylenol. — ChEBI

IUPAC name
4-chloro-3,5-dimethylphenol
Molecular formula
C8H9ClO
Molecular weight
156.61 g/mol
Exact mass
156.0341926 Da
XLogP3
2.0
Topological polar surface area
20.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

chloroxylenolPCMX4-Chloro-3,5-xylenolBenzytolp-Chloro-m-xylenolOttaseptparachlorometaxylenol2-Chloro-m-xylenol
16 more reported names
4-Chloro-m-xylenolDessonEspadolChloro-xylenolOttasept ExtraPhenol, 4-chloro-3,5-dimethyl-Husept ExtraWillenol V3,5-Dimethyl-4-chlorophenolp-Chloro-3,5-xylenolCloroxilenolSeptiderm-HydrochlorideChloroxylenolumChlorxylenolumDettol, liquid antiseptic2-Chloro-5-hydroxy-m-xylene
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

0.5%

INCI glossary name

CHLOROXYLENOL

Chemical name

Chloroxylenol

Chemical / IUPAC name

Phenol, 4-chloro-3,5-dimethyl-

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
88-04-0 / 1321-23-9
EC
201-793-8 / 215-316-6
Annex
V
Entry number
26

Inventory links for CHLOROXYLENOL

Inventory Restriction reference
Ref 32666

CHLOROXYLENOL

CAS: 88-04-0 / 1321-23-9
EC: 201-793-8 / 215-316-6

Direct matches are limited for this record, so nearby entries from Annex V are shown as well.

Annex V 25
Nearby record in the same annex

Triclosan

CAS: 3380-34-5
EC: 222-182-2
Annex V 28
Nearby record in the same annex

POLYAMINOPROPYL BIGUANIDE

CAS: 32289-58-0 [1]/ 27083-27-8 [2]/ 28757-47-3 [3]/ 133029-32-0 [4]
EC: 608-723-9 [1]/ 608-042-7 [2]
Annex V 23
Nearby record in the same annex

Triclocarban

CAS: 101-20-2
EC: 202-924-1
Annex V 29
Nearby record in the same annex

PHENOXYETHANOL

CAS: 122-99-6
EC: 204-589-7
Annex V 30
Nearby record in the same annex

METHENAMINE

CAS: 100-97-0
EC: 202-905-8
Annex V 32
Nearby record in the same annex

CLIMBAZOLE

CAS: 38083-17-9
EC: 253-775-4
Annex V 33
Nearby record in the same annex

DMDM HYDANTOIN

CAS: 6440-58-0
EC: 229-222-8

What Annex V means for CHLOROXYLENOL

CHLOROXYLENOL is an approved preservative listed in Annex V of EU Cosmetics Regulation 1223/2009. Only substances on this positive list may be used as cosmetic preservatives in the EU.

Each preservative entry specifies maximum permitted concentrations and applicable product scope. Concentrations must not exceed the listed maximum. Some preservatives require warning statements on the product label.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Use concentration must not exceed: 0.5%
  • Verify the preservative is effective at the permitted concentration for your matrix.

Frequently asked questions

Yes. CHLOROXYLENOL is listed in Annex V of EU Cosmetics Regulation 1223/2009 as a permitted preservative. It may be used in cosmetics up to the maximum concentration specified above, within the permitted product scope.

CAS 88-04-0 / 1321-23-9 is the unique numerical identifier assigned to CHLOROXYLENOL by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 0.5% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex V record CHLOROXYLENOL

This page summarizes one Annex V record for CHLOROXYLENOL from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex V conditions for CHLOROXYLENOL, but confirm any final regulatory decision against the current official annex wording and source files.

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