What is CAS 101-20-2 for Triclocarban?

CAS 101-20-2 is the unique numerical identifier assigned to Triclocarban by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

How is the maximum concentration of Triclocarban calculated in a finished product?

The maximum concentration of 0,2 % applies to the substance in the ready-to-use cosmetic product. When supplied as part of a blend or mixture, the calculation must account for contributions from all sources in the formulation.

Annex V Entry 23 04/04/2024

Triclocarban

Q: How do I check if my product formula contains Triclocarban?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Triclocarban appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: 0,2 %.

Permitted preservative— Annex V, EU Regulation 1223/2009

Max conc.: 0,2 %

Entry: 23

Chemical identity and properties

PubChem 2D chemical structure for CAS 101-20-2

CAS 101-20-2PubChem CID 7547

Triclocarban

Triclocarban is a member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively. It has a role as an antimicrobial agent, a xenobiotic, an antiseptic drug, a disinfectant and an environmental contaminant. It is a member of phenylureas, a dichlorobenzene and a member of monochlorobenzenes. It is functionally related to a 1,3-diphenylurea. — ChEBI

IUPAC name: 1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea

Molecular formula: C13H9Cl3N2O
Molecular weight: 315.6 g/mol
Exact mass: 313.978046 Da
XLogP3: 5.3
Topological polar surface area: 41.1 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

3,4,4'-TRICHLOROCARBANILIDECutisanProcuteneSolubacterCusiterGenofaceTrilocarbanUrea, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-

16 more reported names

3,4,4'-TrichlorodiphenylureaTrichlocarbanTriclocarbanumN-(4-Chlorophenyl)-N'-(3,4-dichlorophenyl)ureaNSC-72005TCC Soap3,4,4'-trichloro carbanilide1-(3',4'-Dichlorophenyl)-3-(4'-chlorophenyl)ureaENT 26925TCC (soap bacteriostat)Carbanilide, 3,4,4'-trichloro-CP 78416N-(3,4-Dichlorophenyl)-N'-(4-chlorophenyl)ureaBGG1Y1ED0YEPA Pesticide Chemical Code 027901CHEBI:48347

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:48347
ChEMBL:CHEMBL1076347
EPA DTXSID:DTXSID4026214
PubMed:38631510
PubMed:37385329
PubMed:35413382
PubMed:35164063
PubMed:32065294
PubMed:31868902
PubMed:31576746
PubMed:30940137
PubMed:30657620
PubMed:30592132
PubMed:27979590
PubMed:26827900

Evidence from additional scientific databases

EMBL-EBI ChEBI

Exact identifier matchCHEBI:48347

triclocarban

A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.

Formula: C13H9Cl3N2O
Average mass: 315.587 g/mol
Monoisotopic mass: 313.97805 Da
Formal charge: 0

phenylureas — is a (CHEBI:134043)
dichlorobenzene — is a (CHEBI:23697)
monochlorobenzenes — is a (CHEBI:83403)

disinfectant — has role (CHEBI:48219)
antiseptic drug — has role (CHEBI:48218)
xenobiotic — has role (CHEBI:35703)
antimicrobial agent — has role (CHEBI:33281)
environmental contaminant — has role (CHEBI:78298)

1,3-diphenylurea — has functional parent (CHEBI:41320)
disinfectant — has role (CHEBI:48219)
antiseptic drug — has role (CHEBI:48218)
xenobiotic — has role (CHEBI:35703)
antimicrobial agent — has role (CHEBI:33281)
environmental contaminant — has role (CHEBI:78298)
phenylureas — is a (CHEBI:134043)
dichlorobenzene — is a (CHEBI:23697)
monochlorobenzenes — is a (CHEBI:83403)

18048496 Source: PubMed
19850474 Source: PubMed
21243104 Source: PubMed
21840723 Source: PubMed
21953915 Source: PubMed
24461429 Source: PubMed
24464075 Source: PubMed
24562054 Source: PubMed
30033524 Source: PubMed
37468498 Source: PubMed

Additional curated names

1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea1-(3',4'-dichlorophenyl)-3-(4'-chlorophenyl)urea3,4,4'-trichloro carbanilide3,4,4'-trichlorocarbanilide3,4,4'-trichlorodiphenylureaN-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)ureaNSC-72005TCC

Cross-references from this source

CAS: 101-20-2 — NIST Chemistry WebBook
CAS: 101-20-2 — ChemIDplus
REGISTRY_NUMBER: 2814890 — Reaxys
MANUAL_X_REF: 3630 — DrugCentral
MANUAL_X_REF: D06223 — KEGG DRUG
MANUAL_X_REF: DB11155 — DrugBank
MANUAL_X_REF: GB769273 — Patent
MANUAL_X_REF: Triclocarban — Wikipedia
MANUAL_X_REF: US2818390 — Patent

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2018-12-13. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View

Exact identifier match7547

Attributed physical-property, hazard, environmental and use annotations.

Boiling Point: 250 °C at 97.8 kPa (733 mm Hg) Source: Hazardous Substances Data Bank (HSDB)

Color/Form: Fine white plates Source: Hazardous Substances Data Bank (HSDB)
Color/Form: Fine plates Source: Hazardous Substances Data Bank (HSDB)
Color/Form: Fine, white to off-white powder Source: Hazardous Substances Data Bank (HSDB)

Density: 0.336 g/cu cm at 20 °C Source: Hazardous Substances Data Bank (HSDB)

Dissociation Constants: pKa = 12.7 Source: Hazardous Substances Data Bank (HSDB)

LogP: log Kow = 4.342 at 25 °C, pH 8.1 Source: Hazardous Substances Data Bank (HSDB)

Melting Point: 482 to 493 °F (NTP, 1992) Source: CAMEO Chemicals
Melting Point: 491.2- 493 Source: DrugBank
Melting Point: 254.4 °C Source: Hazardous Substances Data Bank (HSDB)
Melting Point: MP: 255.2-256 °C Source: Hazardous Substances Data Bank (HSDB)

Odor: Slight, characteristic odor Source: Hazardous Substances Data Bank (HSDB)

Physical Description: Triclocarban appears as fine white plates or white powder. (NTP, 1992) Source: CAMEO Chemicals
Physical Description: White solid; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Solubility: less than 1 mg/mL at 79 °F (NTP, 1992) Source: CAMEO Chemicals
Solubility: Insoluble Source: DrugBank
Solubility: In water, 0.11 mg/L at 20 °C Source: Hazardous Substances Data Bank (HSDB)
Solubility: Practically insoluble in water Source: Hazardous Substances Data Bank (HSDB)
Solubility: 1 g dissolves in 25 mL acetone; 3 mL dimethyl formamide Source: Hazardous Substances Data Bank (HSDB)
Solubility: In methanol, 1.6 g/L at 35 °C Source: Hazardous Substances Data Bank (HSDB)

First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals

Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H400 (96.8%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 185 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Substances Data Bank (HSDB)
Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)

Toxicity Summary: IDENTIFICATION AND USE: Triclocarban (TCC) is a solid. It has anti-microbial activity and is used globally in a wide range of personal cleansing products that include deodorant soaps, detergents, cleansing lotions, and wipes. In North America, TCC is used exclusively as an antimicrobial and preservative in bar and liquid soaps and body washes. HUMAN STUDIES: Studies in humans indicate no evidence of skin sensitization or severe irritation. Petrolatum (0.1mL) containing 0, 1, 3, 6, and 9% TCC was applied continuously for 21 days on ten males. Minimal skin irritation was observed with the 9% concentration. There was no evidence of skin sensitization in volunteers tested with TCC (1.5% and 10%). The potential impact of exposure to TCC on fetal abnormalities was studied in 39 pregnant women diagnosed with fetal or post-birth abnormalities. Significantly increased levels of TCC were detected in maternal sera from mothers with abnormal births. TCC was also studied for its endocrine-disrupting effects. TCC exerted estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and dow Source: Hazardous Substances Data Bank (HSDB)

Environmental Bioconcentration: BCF values for triclocarban in rice fish (Oryzias latipes), exposed for 28 days to 20 and 2.0 ug/L were 80 and 81, respectively(1). A log BCF of 2.86 (BCF = 724) was measured using medaka (Oryzias latipes) exposed to 20 ug/L of triclocarban for 24 hours(2). According to a classification scheme(3), these BCF values suggest bioconcentration in aquatic organisms is moderate to high(SRC). Triclocarban BAFs in algae of 1600 to 2700 from three locations downstream of a waste water treatment plant in Pecan Creek, TX(4). Triclocarban bioaccumulation peaked at day 5 of a 56 day study of worms (Lumbriculus variegatus) in soil containing 22.4 ug/g dry weight triclocarban(5). Body burdens of 25 and 133 ng/g wet wt, corresponding to a biota soil accumulation factor range of 0.22 to 0.7, were reported after 28 days in earthworm (Eisenia foetida) present in 2 soils (Ashkum heavy-textured silty clay loam; Chelsea light-textured fine sand). The soils were amended with municipal (Chicago, IL) biosolids containing an average triclocarban concentration of 9200 ng/g dry wt, resulting in an average trace level soil concentration of 9 ng/g dry wt(6). Source: Hazardous Substances Data Bank (HSDB)

Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 12,000(2) to 71,687(3) indicate that triclocarban is expected to be immobile in soil(SRC). Volatilization of triclocarban from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.5X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Triclocarban is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.6X10-9 mm Hg at 25 °C(SRC), determined from a fragment constant method(5). Utilizing the Japanese MITI test, 1% of the Theoretical BOD was reached in 4 weeks(6) indicating that biodegradation is not an important environmental fate process in soil(SRC). However using a continuous flow activated sludge, 50-100% degradation was obtained in 12 weeks, following lag periods of up to two weeks(7). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: TERRESTRIAL FATE: Dewatered municipal biosolids (DMBs) were applied to a field at a rate of approximately 22 Mg dw/ha in October 2008. Pharmaceuticals and personal care products (PPCPs) were monitored in groundwater, tile drainage, soil, DMB aggregates incorporated into the soil post-land application, and in the grain of wheat grown on the field for a period of approximately 1 year following application. Over 80 PPCPs were analyzed in the source DMB. PPCPs selected for in-depth monitoring included ... triclocarban .... PPCPs in tile were observed twice, approximately 3 weeks and 2 months post-application. Of all PPCPs measured in tile drainage, only carbamazepine, ibuprofen, acetaminophen, triclosan, triclocarban, venlafaxine, and citalopram were detected (5-74 ng/L). PPCPs were not detected in groundwater >2 m depth below the soil surface, and concentrations above detection limits at 2 m depth were only observed once just after the first rain event post-application. In groundwater, all compounds found in tile, except carbamazepine, acetaminophen and citalopram, were detected (10-19 ng/L). PPCPs were detected in DMB aggregates incorporated in soil up to 1 year post-application, wit Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values of 12,000(2) to 71687(3) indicate that triclocarban is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 4.5X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). According to a classification scheme(6), BCF values of 80(7) to 724(8) suggest the potential for bioconcentration in aquatic organisms is moderate to high(SRC). Utilizing the Japanese MITI test, 1% of the Theoretical BOD was reached in 4 weeks(7) indicating that biodegradation is not an important environmental fate process in water(SRC). However using a continuous flow activated sludge, 50-100% degradation was obtained in 12 weeks, following lag periods of up to two weeks(9). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), triclocarban, which has an estimated vapor pressure of 3.6X10-9 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase triclocarban may be removed from the air by wet and dry deposition(SRC). Triclocarban contains chromophores that absorb at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Sources/Uses: Used as an antiseptic in cleaning products; [Merck Index] Used for skin and mucous membrane disinfection; [Reference #1] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Industrial Processes with risk of exposure: Using Disinfectants or Biocides [Category: Clean] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: For 3,4,4'-trichlorocarbanilide (USEPA/OPP Pesticide Code: 027901) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
Uses: Bacteriostat and antiseptic in soaps and other cleansing compositions. Source: Hazardous Substances Data Bank (HSDB)
Uses: Bacteriostat in ... plastics. Source: Hazardous Substances Data Bank (HSDB)
Uses: Triclocarban is an anti-microbial active ingredient used globally in a wide range of personal cleansing products that include deodorant soaps, detergents, cleansing lotions, and wipes. In North America, triclocarban is used exclusively as an antimicrobial and preservative in bar and liquid soaps and body washes. Source: Hazardous Substances Data Bank (HSDB)
Uses: Deodorant soaps contain an active ingredient such as 3,4,4'-trichlorocarbanilide (trichlocarban) to inhibit the growth of skin bacteria responsible for the formation of odor-causing substances from perspiration Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
EMBL-EBI ChEBI	Exact match	2026-08-31
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

0,2 %

Product type

All cosmetic products, with the exception of mouthwash.

Other restrictions

Purity criteria:
3,3',4,4'-Tetrachloroazobenzene ≤ 1 ppm
3,3',4,4'-Tetrachloroazoxybenzene ≤ 1 ppm

Not to be used in toothpaste intended for children under 6 years of age.

Cosmetic products containing that substance that do not comply with the conditions may, provided that they comply with the conditions applicable on 23 April 2024, be placed on the Union market until 31 December 2024 and, if they have already been placed on the market before that date, continue to be made available on the Union market until 31 October 2025.

Warnings

For toothpaste containing Triclocarban the following labelling is obligatory: ‘Not to be used for children under 6 years of age’.

INCI glossary name

Triclocarban

Chemical name

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Regulatory information

Regulation

(EU) 2024/996

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS

101-20-2

202-924-1

Annex

Entry number

Inventory links for Triclocarban

Inventory Restriction reference

Ref 38662

TRICLOCARBAN

CAS: 101-20-2

EC: 202-924-1

Direct matches are limited for this record, so nearby entries from Annex V are shown as well.

Annex III 100

Shared CAS number