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Annex V Entry 25 04/04/2024

Triclosan

5-Chloro-2-(2,4-dichlorophenoxy)phenol

Triclosan appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: 0.3%.

Permitted preservative— Annex V, EU Regulation 1223/2009
Max conc.: 0.3%
Entry: 25

Reading this entry

Triclosan is permitted as a preservative only in a closed list of product types, at 0.3%, and not in toothpaste for children under three. Outside that list it may not be used as a preservative at all.

  • 0.3%, and only in toothpastes, hand soaps, body soaps and shower gels, non-spray deodorants, face powders, blemish concealers, and nail-cleaning products.
  • Not permitted in toothpaste intended for children under three years of age.
  • Toothpaste containing it must be labelled 'Not to be used for children under 3 years of age'.
  • Annex V is a positive list: a product type absent from this entry is a product type where it is not permitted.

Annex V works the opposite way round from Annex II, and this entry is a good illustration of why that matters. The list of product types is not guidance about where triclosan is typically used. It is the complete set of places it may be used as a preservative. A rinse-off cleanser that is not a hand soap, a body soap or a shower gel is not on that list, and the absence is the answer.

The children's exclusion is written twice over, and both halves bind. The substance may not be used in toothpaste intended for children under three, and toothpaste that does contain it must carry the warning. A product cannot satisfy the second requirement instead of the first.

Regulation (EU) 2024/996 set the current conditions. Products meeting the rules as they stood on 23 April 2024 could be placed on the market until 31 December 2024, and that window has closed.

Checked against

Chemical identity and properties

PubChem 2D chemical structure for CAS 3380-34-5
CAS 3380-34-5PubChem CID 5564

Triclosan

Triclosan is an aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes. It has a role as an EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor, a fungicide, an antibacterial agent, a xenobiotic, an antimalarial, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, a persistent organic pollutant and a drug allergen. It is a dichlorobenzene, a member of phenols, an aromatic ether and a member of monochlorobenzenes. ChEBI

IUPAC name
5-chloro-2-(2,4-dichlorophenoxy)phenol
Molecular formula
C12H7Cl3O2
Molecular weight
289.5 g/mol
Exact mass
287.951163 Da
XLogP3
5.0
Topological polar surface area
29.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

Cloxifenolum2,4,4'-Trichloro-2'-hydroxydiphenyl etherTriclosanumIrgasan DP300Stri-Dex Cleansing BarStri-Dex Face WashCH 3565Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
16 more reported names
Lexol 3005-Chloro-2-(2,4-dichloro-phenoxy)-phenolCH-3565Phenyl ether, 2'-hydroxy-2,4,4'-trichloro-NSC-759151CHEBI:1642004NM5039Y5XtriclosanoGermasidolClearskinDermacareFreshandsGermicidaPacificPanachePrevens
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

0.3%

Other restrictions

Not to be used in toothpaste intended for children under 3 years of age.

Cosmetic products containing that substance that do not comply with the conditions may, provided that they comply with the conditions applicable on 23 April 2024, be placed on the Union market until 31 December 2024 and, if they have already been placed on the market before that date, continue to be made available on the Union market until 31 October 2025.

Warnings

For toothpaste containing Triclosan the following labelling is obligatory: ‘Not to be used for children under 3 years of age’.

INCI glossary name

Triclosan

Chemical name

5-Chloro-2-(2,4-dichlorophenoxy)phenol

Chemical / IUPAC name

5-Chloro-2-(2,4-dichlorophenoxy)phenol

Regulatory information

Key data

Annex
Entry number
25

Inventory links for Triclosan

Inventory Restriction reference
Ref 38663

TRICLOSAN

CAS: 3380-34-5
EC: 222-182-2

Direct matches are limited for this record, so nearby entries from Annex V are shown as well.

Annex V 26
Nearby record in the same annex

CHLOROXYLENOL

CAS: 88-04-0 / 1321-23-9
EC: 201-793-8 / 215-316-6
Annex V 23
Nearby record in the same annex

Triclocarban

CAS: 101-20-2
EC: 202-924-1
Annex V 28
Nearby record in the same annex

POLYAMINOPROPYL BIGUANIDE

CAS: 32289-58-0 [1]/ 27083-27-8 [2]/ 28757-47-3 [3]/ 133029-32-0 [4]
EC: 608-723-9 [1]/ 608-042-7 [2]
Annex V 29
Nearby record in the same annex

PHENOXYETHANOL

CAS: 122-99-6
EC: 204-589-7
Annex V 30
Nearby record in the same annex

METHENAMINE

CAS: 100-97-0
EC: 202-905-8
Annex V 19
Nearby record in the same annex

Hexetidine

CAS: 141-94-6
EC: 205-513-5
Annex V 32
Nearby record in the same annex

CLIMBAZOLE

CAS: 38083-17-9
EC: 253-775-4

What Annex V means for Triclosan

Triclosan is an approved preservative listed in Annex V of EU Cosmetics Regulation 1223/2009. Only substances on this positive list may be used as cosmetic preservatives in the EU.

Each preservative entry specifies maximum permitted concentrations and applicable product scope. Concentrations must not exceed the listed maximum. Some preservatives require warning statements on the product label.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Use concentration must not exceed: 0.3%
  • Verify the preservative is effective at the permitted concentration for your matrix.
  • Apply required label warning statement.

Frequently asked questions

Yes. Triclosan is listed in Annex V of EU Cosmetics Regulation 1223/2009 as a permitted preservative. It may be used in cosmetics up to the maximum concentration specified above, within the permitted product scope.

CAS 3380-34-5 is the unique numerical identifier assigned to Triclosan by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 0.3% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

Source note for Annex V record Triclosan

This page summarizes one Annex V record for Triclosan from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex V conditions for Triclosan, but confirm any final regulatory decision against the current official annex wording and source files.

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