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Annex V Entry 20 02/08/2021

5-BROMO-5-NITRO-1,3-DIOXANE

5-Bromo-5-nitro-1,3-dioxane

5-BROMO-5-NITRO-1,3-DIOXANE appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: 0.1%.

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Permitted preservative— Annex V, EU Regulation 1223/2009
Max conc.: 0.1%
Entry: 20

Chemical identity and properties

PubChem 2D chemical structure for CAS 30007-47-7
CAS 30007-47-7PubChem CID 1807

5-Bromo-5-Nitro-1,3-Dioxane

Bronidox is an organobromide that is a nitrobromo derivative of dioxane. It is used as a stabilizer, surfacant, bactericide, and a preservative in immunology and cosmetics. It is corrosive to metals. Bronidox has been used in cosmetics since the mid-1970s as preservative for shampoos and foam baths. — Toxin and Toxin Target Database (T3DB)

IUPAC name
5-bromo-5-nitro-1,3-dioxane
Molecular formula
C4H6BrNO4
Molecular weight
212.00 g/mol
Exact mass
210.94802 Da
XLogP3
0.3
Topological polar surface area
64.3 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

Bronidox1,3-Dioxane, 5-bromo-5-nitro-5-Bromo-5-nitro-m-dioxanem-DIOXANE, 5-BROMO-5-NITRO-5-Brom-5-nitro-1,3-dioxanU184I9QBNMMICROCIDE IRefChem:102179
16 more reported names
5-bromo-5-nitro-1,3 dioxane250-001-7C4H6BrNO4EINECS 250-001-7UNII-U184I9QBNM5-Brom-5-nitro-1,3-dioxan [German]BRN 4668673Bronidox L5-bromo-5-nitro-13-dioxaneGLXC-08136Tox21_301588CS-W015032HY-W014316AS-159415-Bromo-5-nitro-1,3-dioxane, >=99%CAS-30007-47-7
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

0.1%

Product type

Rinse-off products

Other restrictions

Avoid formation of nitrosamines

INCI glossary name

5-BROMO-5-NITRO-1,3-DIOXANE

Chemical name

5-Bromo-5-nitro-1,3-dioxane

Chemical / IUPAC name

5-Bromo-5-nitro-1,3-dioxane

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
30007-47-7
EC
250-001-7
Annex
V
Entry number
20

Inventory links for 5-BROMO-5-NITRO-1,3-DIOXANE

Annex III 100
Shared product type

TRICLOCARBAN

CAS: 101-20-2
EC: 202-924-1
Annex III 257
Shared product type

LAURETH-9

CAS: 3055-99-0
EC: 221-284-4

What Annex V means for 5-BROMO-5-NITRO-1,3-DIOXANE

5-BROMO-5-NITRO-1,3-DIOXANE is an approved preservative listed in Annex V of EU Cosmetics Regulation 1223/2009. Only substances on this positive list may be used as cosmetic preservatives in the EU.

Each preservative entry specifies maximum permitted concentrations and applicable product scope. Concentrations must not exceed the listed maximum. Some preservatives require warning statements on the product label.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Use concentration must not exceed: 0.1%
  • Verify the preservative is effective at the permitted concentration for your matrix.

Frequently asked questions

Yes. 5-BROMO-5-NITRO-1,3-DIOXANE is listed in Annex V of EU Cosmetics Regulation 1223/2009 as a permitted preservative. It may be used in cosmetics up to the maximum concentration specified above, within the permitted product scope.

CAS 30007-47-7 is the unique numerical identifier assigned to 5-BROMO-5-NITRO-1,3-DIOXANE by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 0.1% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex V record 5-BROMO-5-NITRO-1,3-DIOXANE

This page summarizes one Annex V record for 5-BROMO-5-NITRO-1,3-DIOXANE from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex V conditions for 5-BROMO-5-NITRO-1,3-DIOXANE, but confirm any final regulatory decision against the current official annex wording and source files.

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