Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Annex V Entry 32 28/07/2020

CLIMBAZOLE

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

CLIMBAZOLE appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: (a) 0,2 % (b) 0,2 % (c) 0,2 % (d) 0,5 %.

Search similar Back to annex Compare Calculate concentration
Permitted preservative— Annex V, EU Regulation 1223/2009
Max conc.: (a) 0,2 % (b) 0,2 % (c) 0,2 % (d) 0,5 %
Entry: 32

Chemical identity and properties

PubChem 2D chemical structure for CAS 38083-17-9
CAS 38083-17-9PubChem CID 37907

Climbazole

1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a hemiaminal ether, a ketone, a member of imidazoles, an aromatic ether and a member of monochlorobenzenes. — ChEBI

IUPAC name
1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one
Molecular formula
C15H17ClN2O2
Molecular weight
292.76 g/mol
Exact mass
292.0978555 Da
XLogP3
3.7
Topological polar surface area
44.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

ClimbazolBaypivalCrinipan ADBAY-E 6975BaysanClimbazolum2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-NSC-759808
16 more reported names
9N42CW7I541-(p-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone(RS)-1-(4-CHLOROPHENOXY)-1-IMIDAZOL-1-YL-3,3-DIMETHYLBUTAN-2-ONERefChem:577718CHEBI:83499253-775-41-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one1-(4-Clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanoneClimbazol [INN-Spanish]Climbazolum [INN-Latin]CAS-38083-17-9Climbazole [INN:BAN]EINECS 253-775-4BRN 0618020Bay e 6975
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

(a) 0,2 % (b) 0,2 % (c) 0,2 % (d) 0,5 %

Product type

Hair lotions Face creams Foot care products Rinse-off shampoo

INCI glossary name

CLIMBAZOLE

Chemical name

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

Chemical / IUPAC name

(R,S)-1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one

Regulatory information

Regulation

(EU) 2019/698

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
38083-17-9
EC
253-775-4
Annex
V
Entry number
32

Inventory links for CLIMBAZOLE

Inventory Restriction reference
Ref 32909

CLIMBAZOLE

CAS: 38083-17-9
EC: 253-775-4

Direct matches are limited for this record, so nearby entries from Annex V are shown as well.

Annex III 310
Shared CAS number

CLIMBAZOLE

CAS: 38083-17-9;
EC: 253-775-4;
Annex V 30
Nearby record in the same annex

METHENAMINE

CAS: 100-97-0
EC: 202-905-8
Annex V 33
Nearby record in the same annex

DMDM HYDANTOIN

CAS: 6440-58-0
EC: 229-222-8
Annex V 29
Nearby record in the same annex

PHENOXYETHANOL

CAS: 122-99-6
EC: 204-589-7
Annex V 34
Nearby record in the same annex

BENZYL ALCOHOL

CAS: 100-51-6
EC: 202-859-9
Annex V 28
Nearby record in the same annex

POLYAMINOPROPYL BIGUANIDE

CAS: 32289-58-0 [1]/ 27083-27-8 [2]/ 28757-47-3 [3]/ 133029-32-0 [4]
EC: 608-723-9 [1]/ 608-042-7 [2]
Annex V 26
Nearby record in the same annex

CHLOROXYLENOL

CAS: 88-04-0 / 1321-23-9
EC: 201-793-8 / 215-316-6
Annex V 25
Nearby record in the same annex

Triclosan

CAS: 3380-34-5
EC: 222-182-2
Annex V 38
Nearby record in the same annex

O-CYMEN-5-OL

CAS: 3228-02-2
EC: 221-761-7

What Annex V means for CLIMBAZOLE

CLIMBAZOLE is an approved preservative listed in Annex V of EU Cosmetics Regulation 1223/2009. Only substances on this positive list may be used as cosmetic preservatives in the EU.

Each preservative entry specifies maximum permitted concentrations and applicable product scope. Concentrations must not exceed the listed maximum. Some preservatives require warning statements on the product label.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Use concentration must not exceed: (a) 0,2 % (b) 0,2 % (c) 0,2 % (d) 0,5 %
  • Verify the preservative is effective at the permitted concentration for your matrix.

Frequently asked questions

Yes. CLIMBAZOLE is listed in Annex V of EU Cosmetics Regulation 1223/2009 as a permitted preservative. It may be used in cosmetics up to the maximum concentration specified above, within the permitted product scope.

CAS 38083-17-9 is the unique numerical identifier assigned to CLIMBAZOLE by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of (a) 0,2 % (b) 0,2 % (c) 0,2 % (d) 0,5 % applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Open INCI Checker

Source note for Annex V record CLIMBAZOLE

This page summarizes one Annex V record for CLIMBAZOLE from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex V conditions for CLIMBAZOLE, but confirm any final regulatory decision against the current official annex wording and source files.

View sourcesView updates

Tools & next steps

Check your formula

Paste a full INCI list to detect CLIMBAZOLE and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare CLIMBAZOLE side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex V and compare regulatory conditions across substances in this annex.

Open Annex V