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ProhibitedBinding ruleCNOfficial English translationOfficial-source import checked

抗组胺药，包括但不限于溴苯那敏及其 盐类、氯苯沙明、赛克利嗪及其盐类、 苯海拉明及其盐类、多西拉敏及其盐 类、羟嗪、曲吡那敏、西咪替丁等 — Antihistamines, including but not limited to Brompheniramine （INN） （CAS No. 86-22-6）and its salts, Chlorphenoxamine （INN） （CAS No. 77-38-3）, Cyclizine （INN） （CAS No. 82-92-8） and its salts, Diphenhydramine （INN） （CAS No. 58-73-1） and its salts, Doxylamine （INN） （CAS No. 469-21-6） and its salts, Hydroxyzine （INN） （CAS No. 68-88-2）, Tripelennamine （INN） （CAS No. 91-81-6）, Cimetidine （INN） （CAS No. 51481-61-9）

Antihistamines, including but not limited to Brompheniramine （INN） （CAS No. 86-22-6）and its salts, Chlorphenoxamine （INN） （CAS No. 77-38-3）, Cyclizine （INN） （CAS No. 82-92-8） and its salts, Diphenhydramine （INN） （CAS No. 58-73-1） and its salts, Doxylamine

The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.

All China recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.
Conditions and restrictions
Prohibited in cosmetic product formulas. Verify the cited Chinese source identity and any later NMPA amendment before use.

Substance identity

Official source name
抗组胺药，包括但不限于溴苯那敏及其 盐类、氯苯沙明、赛克利嗪及其盐类、 苯海拉明及其盐类、多西拉敏及其盐 类、羟嗪、曲吡那敏、西咪替丁等 — Antihistamines, including but not limited to Brompheniramine （INN） （CAS No. 86-22-6）and its salts, Chlorphenoxamine （INN） （CAS No. 77-38-3）, Cyclizine （INN） （CAS No. 82-92-8） and its salts, Diphenhydramine （INN） （CAS No. 58-73-1） and its salts, Doxylamine （INN） （CAS No. 469-21-6） and its salts, Hydroxyzine （INN） （CAS No. 68-88-2）, Tripelennamine （INN） （CAS No. 91-81-6）, Cimetidine （INN） （CAS No. 51481-61-9）
CAS
86-22-6; 77-38-3; 82-92-8; 58-73-1; 469-21-6; 68-88-2; 91-81-6; 51481-61-9
EC
Not supplied in this source row
Identity mapping
standalone:official_nmpa_record
Search this identity across the siteCAS 86-22-6CAS 77-38-3CAS 82-92-8CAS 58-73-1CAS 469-21-6CAS 68-88-2CAS 91-81-6CAS 51481-61-9

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 469-21-6
CAS 469-21-6PubChem CID 3162

Verified chemistry for CAS 469-21-6

Doxylamine

Doxylamine is a member of pyridines and a tertiary amine. It has a role as a sedative, a H1-receptor antagonist, a histamine antagonist, a cholinergic antagonist, an anti-allergic agent, an antiemetic and an antitussive. — ChEBI

IUPAC name
N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine
Molecular formula
C17H22N2O
Molecular weight
270.37 g/mol
Exact mass
270.173213330 Da
Monoisotopic mass
270.173213330 Da
XLogP3
2.5
Topological polar surface area
25.4 Ų
Molecular complexity
276.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
6
Heavy atoms
20
Covalent units
1

Names and synonyms reported to PubChem

DossilaminaDoxylaminumDoxilminiodoxilamina2-Dimethylaminoethoxyphenylmethyl-2-picolineN,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanaminePhenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine
16 more reported names
95QB77JKPLdimethyl({2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethyl})amineEthanamine, N,N-dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)-CHEBI:51380Pyridine, 2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)-Ethanamine, N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]-dimethyl((2-(1-phenyl-1-(pyridin-2-yl)ethoxy)ethyl))amine(+-)-DoxylamineRefChem:55070R06AA09207-414-2(+/-)-DoxylamineS-DoxylamineNCI C60684Doxylamine (INN)Doxylaminephenyl-d5
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
2
3D hydrophobes
0
3D acceptor features
2
3D donor features
0
3D anionic centres
0
3D cationic centres
1
3D conformers
10
Effective 3D rotors
6.0
Machine-readable structure identifiers
SMILES
CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C
InChI
InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3
InChIKey
HCFDWZZGGLSKEP-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 51481-61-9
CAS 51481-61-9PubChem CID 2756

Verified chemistry for CAS 51481-61-9

Cimetidine

Cimetidine is a member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach. It has a role as an analgesic, a H2-receptor antagonist, an anti-ulcer drug, a P450 inhibitor and an adjuvant. It is a nitrile, an aliphatic sulfide, a member of guanidines and a member of imidazoles. — ChEBI

IUPAC name
1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
Molecular formula
C10H16N6S
Molecular weight
252.34 g/mol
Exact mass
252.11571571 Da
Monoisotopic mass
252.11571571 Da
XLogP3
0.4
Topological polar surface area
114.0 Ų
Molecular complexity
296.0
Formal charge
0
Hydrogen-bond donors
3
Hydrogen-bond acceptors
4
Rotatable bonds
7
Heavy atoms
17
Covalent units
1

Names and synonyms reported to PubChem

UlcedinEureceptorGastrometUlcimetAcinilUlcomedinaTametinCimal
16 more reported names
AcibilinCimetagDyspametEdaleneUlcedineUlcometCimetidinaCimetumTratulUlhysSKF-92334Tagamet HbTagamet Hb 200CimetidinumMetracinUlcerfen
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
7
3D rings
1
3D hydrophobes
0
3D acceptor features
1
3D donor features
3
3D anionic centres
0
3D cationic centres
2
3D conformers
10
Effective 3D rotors
7.0
Machine-readable structure identifiers
SMILES
CC1=C(N=CN1)CSCCNC(=NC)NC#N
InChI
InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
InChIKey
AQIXAKUUQRKLND-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 58-73-1
CAS 58-73-1PubChem CID 3100

Verified chemistry for CAS 58-73-1

Diphenhydramine

IUPAC name
2-benzhydryloxy-N,N-dimethylethanamine
Molecular formula
C17H21NO
Molecular weight
255.35 g/mol
Exact mass
255.162314293 Da
Monoisotopic mass
255.162314293 Da
XLogP3
3.3
Topological polar surface area
12.5 Ų
Molecular complexity
211.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Rotatable bonds
6
Heavy atoms
19
Covalent units
1

Names and synonyms reported to PubChem

BenzhydramineAlledrylProbedrylDihidralAntistominumBenzhydraminumBenzhydroaminaDiphantine
16 more reported names
BaramineDermodrinDesentolDibondrinHistaxinBenylanDifenhidraminaDifenidraminaRestaminRigidylDiphenylhydramineDiphenhydraminumEthanamine, 2-(diphenylmethoxy)-N,N-dimethyl-O-Benzhydryldimethylaminoethanol2-(Benzhydryloxy)-N,N-dimethylethylamineFAR 90X2
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
2
3D hydrophobes
0
3D acceptor features
1
3D donor features
0
3D anionic centres
0
3D cationic centres
1
3D conformers
10
Effective 3D rotors
6.0
Machine-readable structure identifiers
SMILES
CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2
InChI
InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
InChIKey
ZZVUWRFHKOJYTH-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 68-88-2
CAS 68-88-2PubChem CID 3658

Verified chemistry for CAS 68-88-2

Hydroxyzine

Hydroxyzine is a N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively. It has a role as an anticoronaviral agent, an anxiolytic drug, a H1-receptor antagonist, a dermatologic drug and an antipruritic drug. It is a hydroxyether, a N-alkylpiperazine and a member of monochlorobenzenes. — ChEBI

IUPAC name
2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol
Molecular formula
C21H27ClN2O2
Molecular weight
374.9 g/mol
Exact mass
374.1761058 Da
Monoisotopic mass
374.1761058 Da
XLogP3
3.7
Topological polar surface area
35.9 Ų
Molecular complexity
376.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
4
Rotatable bonds
8
Heavy atoms
26
Covalent units
1

Names and synonyms reported to PubChem

HydroxizineHydroxyzinHydroxineHydroxycineTranquizineAtaraxoidHychotineTran-Q
16 more reported names
HydroxizinumAtarazoidNeurozinaAtazinaDeinaitFenarolPamazonePaxistilPlacidolPlaxidolAtaraAteraxneo-CalmaIdrossizinaVesparaz-WirkstoffHidroxizina
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
8
3D rings
3
3D hydrophobes
0
3D acceptor features
2
3D donor features
1
3D anionic centres
0
3D cationic centres
2
3D conformers
10
Effective 3D rotors
9.2
Machine-readable structure identifiers
SMILES
C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
InChI
InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2
InChIKey
ZQDWXGKKHFNSQK-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 77-38-3
CAS 77-38-3PubChem CID 6475

Verified chemistry for CAS 77-38-3

Chlorphenoxamine

IUPAC name
2-[1-(4-chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine
Molecular formula
C18H22ClNO
Molecular weight
303.8 g/mol
Exact mass
303.1389920 Da
Monoisotopic mass
303.1389920 Da
XLogP3
4.1
Topological polar surface area
12.5 Ų
Molecular complexity
296.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Rotatable bonds
6
Heavy atoms
21
Covalent units
1

Names and synonyms reported to PubChem

ContristamineClorfenoxaminaClorfenossaminaChlorphenoxaminum3UVD77BP8R2-(1-(p-Chlorophenyl)-1-phenylethoxy)-N,N-dimethylethylamine{2-[1-(4-Chlorophenyl)-1-phenylethoxy]ethyl}dimethylamine(2-(1-(4-chlorophenyl)-1-phenylethoxy)ethyl)dimethylamine
16 more reported names
RefChem:575991D04AA34R06AA06616-456-42-(1-(4-Chlorophenyl)-1-phenylethoxy)-N,N-dimethylethanamineClorfenossamina [DCIT]2-(1-(4-Chlorophenyl)-1-phenylethoxy)-N,N-dimethylethan-1-aminep-Chlor-alpha-methyl-diphenhydramin [German]4-06-00-04717 (Beilstein Handbook Reference)p-Chlor-.alpha.-methyl-diphenhydraminAS-76607Chlorphenoxamine (INN)2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamineEthanamine, 2-[1-(4-chlorophenyl)-1-phenylethoxy]-N,N-dimethyl-CHLORPHENOXAMINE [INN]Ethylamine, 2-[1-(p-chlorophenyl)-1-phenylethoxy]-N,N-dimethyl-
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
4
3D rings
2
3D hydrophobes
0
3D acceptor features
1
3D donor features
0
3D anionic centres
0
3D cationic centres
1
3D conformers
10
Effective 3D rotors
6.0
Machine-readable structure identifiers
SMILES
CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCN(C)C
InChI
InChI=1S/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3
InChIKey
KKHPNPMTPORSQE-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 82-92-8
CAS 82-92-8PubChem CID 6726

Verified chemistry for CAS 82-92-8

Cyclizine

IUPAC name
1-benzhydryl-4-methylpiperazine
Molecular formula
C18H22N2
Molecular weight
266.4 g/mol
Exact mass
266.178298710 Da
Monoisotopic mass
266.178298710 Da
XLogP3
3.6
Topological polar surface area
6.5 Ų
Molecular complexity
253.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Rotatable bonds
3
Heavy atoms
20
Covalent units
1

Names and synonyms reported to PubChem

NautazineCiclizinaNeo-devomit1-(Diphenylmethyl)-4-methylpiperazineCompound 47-83CyclizinumN-Benzhydryl-N'-methylpiperazineN-Methyl-N'-benzhydrylpiperazine
16 more reported names
(N-Benzhydryl)(N'-methyl)diethylenediamineWellcome prepn 47-831-Benzhydryl-4-methylpiperazinPiperazine, 1-(diphenylmethyl)-4-methyl-BW 47-83QRW9FCR9P2(+-)-1-diphenylmethyl-4-methylpiperazineNSC-26608CHEBI:39945-23-01-00232 (Beilstein Handbook Reference)RefChem:129230R06AE03201-445-5MarezineCyclizinum [INN-Latin]Ciclizina [INN-Spanish]
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
3
3D hydrophobes
0
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
2
3D conformers
6
Effective 3D rotors
4.2
Machine-readable structure identifiers
SMILES
CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
InChI
InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3
InChIKey
UVKZSORBKUEBAZ-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 86-22-6
CAS 86-22-6PubChem CID 6834

Verified chemistry for CAS 86-22-6

Brompheniramine

IUPAC name
3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Molecular formula
C16H19BrN2
Molecular weight
319.24 g/mol
Exact mass
318.07316 Da
Monoisotopic mass
318.07316 Da
XLogP3
3.5
Topological polar surface area
16.1 Ų
Molecular complexity
249.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Rotatable bonds
5
Heavy atoms
19
Covalent units
1

Names and synonyms reported to PubChem

ParabromdylamineBromfeniraminaBrompheniraminumBromfedBromfenexBrotane1-(p-Bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane3-(p-Bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
16 more reported names
2-(p-Bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridineDimetapp Allergy3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamineH57G17P2FNgamma-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropanamineCHEBI:31832-Pyridinepropanamine, gamma-(4-bromophenyl)-N,N-dimethyl-Pyridine, 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-[3-(4-bromophenyl)-3-(pyridin-2-yl)propyl]dimethylaminep-Bromdylaminepara-Bromdylamine[3-(4-Bromo-phenyl)-3-pyridin-2-yl-propyl]-dimethyl-amine(3-(4-bromophenyl)-3-(pyridin-2-yl)propyl)dimethylamine(3-(4-Bromo-phenyl)-3-pyridin-2-yl-propyl)-dimethyl-aminep BromdylamineDimetane Ten
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
2
3D hydrophobes
1
3D acceptor features
1
3D donor features
0
3D anionic centres
0
3D cationic centres
1
3D conformers
10
Effective 3D rotors
5.0
Machine-readable structure identifiers
SMILES
CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2
InChI
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
InChIKey
ZDIGNSYAACHWNL-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 91-81-6
CAS 91-81-6PubChem CID 5587

Verified chemistry for CAS 91-81-6

Tripelennamine

Tripelennamine is an aromatic amine. — ChEBI

IUPAC name
N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
Molecular formula
C16H21N3
Molecular weight
255.36 g/mol
Exact mass
255.173547683 Da
Monoisotopic mass
255.173547683 Da
XLogP3
3.3
Topological polar surface area
19.4 Ų
Molecular complexity
236.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
6
Heavy atoms
19
Covalent units
1

Names and synonyms reported to PubChem

Pyrinamine baseTripelennaminBenzoxaleResistamineCizaronTonarilPiribenzilTripelennamina
16 more reported names
PyribenzaminTripelenaminaTripelennaminumN-benzyl-N-[2-(dimethylamino)ethyl]pyridin-2-amine1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-2-(Benzyl(2-dimethylaminoethyl)amino)pyridineN-Benzyl-N',N'-dimethyl-N-2-pyridylethylenediaminebeta-Dimethylaminoethyl-2-pyridylbenzylaminebeta-Dimethylaminoethyl-2-pyridylaminotoluene3C5ORO99TYNSC-118946N,N-Dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-1,2-ethanediamineBenzyl-(alpha-pyridyl)-dimethylaethylendiamin2-[Benzyl(2-dimethylaminoethyl)amino]pyridineN,N-Dimethyl-N'-benzyl-N'-(alpha-pyridyl)ethylenediaminePyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
2
3D hydrophobes
0
3D acceptor features
1
3D donor features
0
3D anionic centres
0
3D cationic centres
2
3D conformers
10
Effective 3D rotors
6.0
Machine-readable structure identifiers
SMILES
CN(C)CCN(CC1=CC=CC=C1)C2=CC=CC=N2
InChI
InChI=1S/C16H21N3/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3
InChIKey
UFLGIAIHIAPJJC-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
China NMPA banned raw-material catalogues (2021)
Source reference
NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 1279
Source record ID
chemical-1279
Source version
NMPA Announcement No. 74 of 2021, effective 2021-05-26
Source language
Chinese with source English/Latin identity
Translation status
Official English translation · English translation
Effective date
2021-05-26
Source updated
2021-05-26
Snapshot checked
2026-08-31 14:13 UTC
Validation method
pdfplumber tables; exact 1,284 + 109 row counts and contiguous source numbering
SHA-256
8848aa3e0c7ac5e74f56fc27927336c4fc2e5bc80137da087c2ca9ba2d2c075e

Registered dataset notes

Dataset coverage
All 1,284 banned raw materials and 109 banned plant/animal raw materials effective from 26 May 2021
Authority note
Binding NMPA catalogues replacing Tables 1 and 2 of the 2015 Technical Specification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1393
current China records
1393
records marked Prohibited
1393
records from this source version
1249
market records with CAS identity

Status distribution

Prohibited: 1393

Condition text is present on 1393 of 1393 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

China market context

Complete prohibited catalogues plus official-source workflow

Coverage version: NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025

All 1,284 banned raw materials and 109 banned plant/animal raw materials, plus the official workflow for the dynamic existing-ingredient inventory, other technical restrictions and new ingredients.

Verification checklist

  1. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  2. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  3. Review technical purpose, use history and any monitoring period.
  4. Confirm Chinese labelling, safety assessment and filing/registration duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “抗组胺药，包括但不限于溴苯那敏及其 盐类、氯苯沙明、赛克利嗪及其盐类、 苯海拉明及其盐类、多西拉敏及其盐 类、羟嗪、曲吡那敏、西咪替丁等 — Antihistamines, including but not limited to Brompheniramine （INN） （CAS No. 86-22-6）and its salts, Chlorphenoxamine （INN） （CAS No. 77-38-3）, Cyclizine （INN） （CAS No. 82-92-8） and its salts, Diphenhydramine （INN） （CAS No. 58-73-1） and its salts, Doxylamine （INN） （CAS No. 469-21-6） and its salts, Hydroxyzine （INN） （CAS No. 68-88-2）, Tripelennamine （INN） （CAS No. 91-81-6）, Cimetidine （INN） （CAS No. 51481-61-9）” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  3. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  4. Review technical purpose, use history and any monitoring period.
  5. Confirm Chinese labelling, safety assessment and filing/registration duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

The record cites NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 1279, source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

抗组胺药，包括但不限于溴苯那敏及其 盐类、氯苯沙明、赛克利嗪及其盐类、 苯海拉明及其盐类、多西拉敏及其盐 类、羟嗪、曲吡那敏、西咪替丁等 — Antihistamines, including but not limited to Brompheniramine （INN） （CAS No. 86-22-6）and its salts, Chlorphenoxamine （INN） （CAS No. 77-38-3）, Cyclizine （INN） （CAS No. 82-92-8） and its salts, Diphenhydramine （INN） （CAS No. 58-73-1） and its salts, Doxylamine （INN） （CAS No. 469-21-6） and its salts, Hydroxyzine （INN） （CAS No. 68-88-2）, Tripelennamine （INN） （CAS No. 91-81-6）, Cimetidine （INN） （CAS No. 51481-61-9）. NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 1279. China. Source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. CosIng Checker regulatory record: https://cosingchecker.com/regulations/cn/records/12968/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for China

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: NMPA Announcement No. 74 of 2021, effective 2021-05-26
  • Effective date: 2021-05-26

What it does not prove

IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source