Why does CAS 469-21-6 appear in more than one EU cosmetic annex?

A substance identified by CAS 469-21-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 469-21-6?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 469-21-6 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 469-21-6

Q: How do I use CAS 469-21-6 for compliance screening?

Cross-reference CAS 469-21-6 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 469-21-6 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 469-21-6

CAS 469-21-6PubChem CID 3162

Doxylamine

Doxylamine is a member of pyridines and a tertiary amine. It has a role as a sedative, a H1-receptor antagonist, a histamine antagonist, a cholinergic antagonist, an anti-allergic agent, an antiemetic and an antitussive. — ChEBI

IUPAC name: N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine

Molecular formula: C17H22N2O
Molecular weight: 270.37 g/mol
Exact mass: 270.173213330 Da
XLogP3: 2.5
Topological polar surface area: 25.4 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

DossilaminaDoxylaminumDoxilminiodoxilamina2-Dimethylaminoethoxyphenylmethyl-2-picolineN,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanaminePhenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine

16 more reported names

95QB77JKPLdimethyl({2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethyl})amineEthanamine, N,N-dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)-CHEBI:51380Pyridine, 2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)-Ethanamine, N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]-dimethyl((2-(1-phenyl-1-(pyridin-2-yl)ethoxy)ethyl))amine(+-)-DoxylamineRefChem:55070R06AA09207-414-2(+/-)-DoxylamineS-DoxylamineNCI C60684Doxylamine (INN)Doxylaminephenyl-d5

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:51380
ChEMBL:CHEMBL1004
EPA DTXSID:DTXSID1022970
PubMed:28437613
PubMed:22937351
PubMed:22651995
PubMed:22618455
PubMed:22589924
PubMed:22512667
PubMed:22436257
PubMed:22346740
PubMed:22346363
PubMed:22337782
PubMed:22265497
PubMed:22190950

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 469-21-6

1 total

Annex

Entry

176

Doxylamine (INN) and its salts

207-414-2

How CAS 469-21-6 is used on this site

CAS 469-21-6 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 469-21-6 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 469-21-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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