Why does CAS 86-22-6 appear in more than one EU cosmetic annex?

A substance identified by CAS 86-22-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 86-22-6?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 86-22-6 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 86-22-6

Q: How do I use CAS 86-22-6 for compliance screening?

Cross-reference CAS 86-22-6 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 86-22-6 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 86-22-6

CAS 86-22-6PubChem CID 6834

Brompheniramine

Brompheniramine is pheniramine in which the hydrogen at position 4 of the phenyl substituent is substituted by bromine. A histamine H1 receptor antagonist, brompheniramine is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis. It has a role as a H1-receptor antagonist and an anti-allergic agent. It is a member of pyridines and an organobromine compound. — ChEBI

IUPAC name: 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine

Molecular formula: C16H19BrN2
Molecular weight: 319.24 g/mol
Exact mass: 318.07316 Da
XLogP3: 3.5
Topological polar surface area: 16.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

ParabromdylamineBromfeniraminaBrompheniraminumBromfedBromfenexBrotane1-(p-Bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane3-(p-Bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine

16 more reported names

2-(p-Bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridineDimetapp Allergy3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamineH57G17P2FNgamma-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropanamineCHEBI:31832-Pyridinepropanamine, gamma-(4-bromophenyl)-N,N-dimethyl-Pyridine, 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-[3-(4-bromophenyl)-3-(pyridin-2-yl)propyl]dimethylaminep-Bromdylaminepara-Bromdylamine[3-(4-Bromo-phenyl)-3-pyridin-2-yl-propyl]-dimethyl-amine(3-(4-bromophenyl)-3-(pyridin-2-yl)propyl)dimethylamine(3-(4-Bromo-phenyl)-3-pyridin-2-yl-propyl)-dimethyl-aminep BromdylamineDimetane Ten

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:3183
ChEMBL:CHEMBL811
EPA DTXSID:DTXSID5022691
PubMed:22612655
PubMed:22372713
PubMed:22337782
PubMed:22213440
PubMed:22055832
PubMed:22037447
PubMed:21982909
PubMed:21772661
PubMed:21577279
PubMed:20961343
PubMed:20689123
PubMed:20463825

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 86-22-6

1 total

Annex

Entry

Brompheniramine (INN) and its salts

201-657-8

How CAS 86-22-6 is used on this site

CAS 86-22-6 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 86-22-6 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 86-22-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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