Why does CAS 68-88-2 appear in more than one EU cosmetic annex?

A substance identified by CAS 68-88-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 68-88-2?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 68-88-2 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 68-88-2

Q: How do I use CAS 68-88-2 for compliance screening?

Cross-reference CAS 68-88-2 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 68-88-2 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 68-88-2

CAS 68-88-2PubChem CID 3658

Hydroxyzine

Hydroxyzine is a N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively. It has a role as an anticoronaviral agent, an anxiolytic drug, a H1-receptor antagonist, a dermatologic drug and an antipruritic drug. It is a hydroxyether, a N-alkylpiperazine and a member of monochlorobenzenes. — ChEBI

IUPAC name: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol

Molecular formula: C21H27ClN2O2
Molecular weight: 374.9 g/mol
Exact mass: 374.1761058 Da
XLogP3: 3.7
Topological polar surface area: 35.9 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

HydroxizineHydroxyzinHydroxineHydroxycineTranquizineAtaraxoidHychotineTran-Q

16 more reported names

HydroxizinumAtarazoidNeurozinaAtazinaDeinaitFenarolPamazonePaxistilPlacidolPlaxidolAtaraAteraxneo-CalmaIdrossizinaVesparaz-WirkstoffHidroxizina

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:5818
ChEMBL:CHEMBL896
EPA DTXSID:DTXSID8023137
PubMed:32020584
PubMed:28480041
PubMed:27999468
PubMed:24709263
PubMed:23330992
PubMed:22188412
PubMed:21892192
PubMed:20564935
PubMed:19909543
PubMed:19549290
PubMed:18693347
PubMed:18379511

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 68-88-2

1 total

Annex

Entry

240

Hydroxyzine (INN)

200-693-1

How CAS 68-88-2 is used on this site

CAS 68-88-2 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 68-88-2 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 68-88-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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