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InventoryRef 3276914/08/2020

CI 45380

Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate

CI 45380 is linked to 2 EU annex records on this page. Inventory note: IV/76 (CI 45380) II/1334 (Solvent Red 43), its disodium salt (Acid Red 87; CI 45380) and its aluminium salt (Pigment Red 90:1 Aluminium lake) when used as a substance in hair dye products.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Prohibited entry found
Open this evidence		2English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandEvidence linked
Prohibited
Open this evidence		1English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 15086-94-9
CAS 15086-94-9PubChem CID 27020

2',4',5',7'-Tetrabromofluorescein

Bromoeosin is an organobromine compound. It is functionally related to a fluorescein (lactone form). — ChEBI

IUPAC name
2',4',5',7'-tetrabromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
Molecular formula
C20H8Br4O5
Molecular weight
647.9 g/mol
Exact mass
647.70642 Da
XLogP3
6.2
Topological polar surface area
76.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

C.I. Solvent Red 43C.I. 45380:23,6-Dihydroxy-2,4,5,7-tetrabromospiro(xanthene-9,3'-phthalide)CI 45380:2NSC-244436Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-2',4',5',7'-tetrabromo-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-oneSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-
16 more reported names
2',4',5',7'-TETRABROMO-3',6'-DIHYDROXY-3H-SPIRO(2-BENZOFURAN-1,9'-XANTHEN)-3-ONE2',4',5',7'-tetrabromo-3',6'-dihydroxyspiro(2-benzofuran-3,9'-xanthene)-1-oneRefChem:1058590CHEBI:86277Solvent Red 43BromoeosinBromeosinEosine acidEosin acidJapan Red 223Japan Red No. 223Eosin Y free acidD and C Red No. 21D & C Red no. 21Acid eosinD&C Red No. 21
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 17372-87-1
CAS 17372-87-1PubChem CID 11048

Eosin

Eosin YS dye is an organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions. It has a role as a fluorochrome and a histological dye. It is an organobromine compound and an organic sodium salt. It contains a 2',4',5',7'-tetrabromofluorescein(2-). — ChEBI

IUPAC name
disodium;2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate
Molecular formula
C20H6Br4Na2O5
Molecular weight
691.9 g/mol
Exact mass
691.67031 Da
Topological polar surface area
89.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Covalent units
3
Defined stereocentres
0

Also known as

Acid red 87Eosin yellowishEosine YellowishEosineEosine GEosin YSSodium eosineBromo acid
16 more reported names
Eosine YBromofluoresceinSodium eosinateBronze BromoCertiqual EosineBromo FluoresceinEosine AEosine JEosine BSEosine DAEosine FAEosine GFEosine OJEosine w/sEosine YBEosine YS
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 94021-89-3
CAS 94021-89-3PubChem CID 44146772

2-(2,4,5,7-tetrabromo-3,6-dihydroxyxanthen-9-yl)benzoic acid, zirconium salt

IUPAC name
tetrakis(2-(2,4,5,7-tetrabromo-3,6-dihydroxy-9H-xanthen-9-yl)benzoate);zirconium(4+)
Molecular formula
C80H36Br16O20Zr
Molecular weight
2686.8 g/mol
Exact mass
2684.7617 Da
Topological polar surface area
359.0 Ų
Hydrogen-bond donors
8
Hydrogen-bond acceptors
20
Covalent units
5
Defined stereocentres
0

Also known as

EINECS 301-481-2RefChem:83900301-481-2Zirconium(4+) tetrakis[2-(2,4,5,7-tetrabromo-3,6-dihydroxy-9H-xanthen-9-yl)benzoate]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CI 45380

INCI name

CI 45380

Description

Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate

Record provenance

Inventory reference
32769
Imported identity
CI 45380
Source update
14/08/2020
European Commission CosIng source notes
Annex IV Restriction reference
Entry 76

CI 45380 / ACID RED 87

CAS: 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3
EC: 241-409-6 / - / 240-005-7 / 239-138-3 / 301-481-2

Key data

CAS
17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3
EC
241-409-6 / - / 240-005-7 / 239-138-3 / 301-481-2
Restriction
IV/76 (CI 45380) II/1334 (Solvent Red 43), its disodium salt (Acid Red 87; CI 45380) and its aluminium salt (Pigment Red 90:1 Aluminium lake) when used as a substance in hair dye products
Function
COLORANT
Exclusively or mainly intended to colour the cosmetic product, the body as a whole or certain parts thereof, by absorption or reflection of visible light. All authorised colorants are substances in the positive list of Annex IV to the Cosmetics Regulation 1223/2009.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#6414 · CI 45380

Ingredients with overlapping formulation functions

CI 45190COLORANT
CI 45220COLORANT
CI 45350COLORANT
CI 45370COLORANT
CI 45396COLORANT
CI 45405COLORANT
CI 45410COLORANT, HAIR DYEING
CI 45425COLORANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How CI 45380 appears in the CosIng inventory

The CosIng inventory lists CI 45380 as a cosmetic ingredient and this page links it to 2 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CI 45380 is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CI 45380 appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for CI 45380 reads: "IV/76 (CI 45380) II/1334 (Solvent Red 43), its disodium salt (Acid Red 87; CI 45380) and its aluminium salt (Pigment Red 90:1 Aluminium lake) when used as a substance in hair dye products". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, CI 45380 carries the following function designation(s):

CAS 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CI 45380

This page combines the CosIng inventory entry for CI 45380 with 2 linked Annex II–VI records from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research CI 45380 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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