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InventoryRef 3276714/08/2020

CI 45350

Disodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate

CI 45350 is linked to 2 EU annex records on this page. Inventory note: IV/74 (CI 45350) II/1332 (Acid Yellow 73 sodium salt; CI 45350) when used as a substance in hair dye products.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Prohibited entry found
Open this evidence		2English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 2321-07-5
CAS 2321-07-5PubChem CID 16850

Fluorescein

Fluorescein (lactone form) is a xanthene dye that is highly fluorescent, detectable even when present in minute quantities. Used forensically to detect traces of blood, in analytical chemistry as an indicator in silver nitrate titrations and in microscopy. It has a role as a radioopaque medium and a fluorescent dye. It is a polyphenol, a gamma-lactone, a xanthene dye, an oxaspiro compound, an organic heteropentacyclic compound and a member of 2-benzofurans. It is functionally related to a fluorescein (acid form). — ChEBI

IUPAC name
3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
Molecular formula
C20H12O5
Molecular weight
332.3 g/mol
Exact mass
332.06847348 Da
XLogP3
3.4
Topological polar surface area
76.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

Solvent Yellow 94ResorcinolphthaleinYellow fluoresceinFluoresceineFluorescein acid3,6-FluorandiolD&C Yellow No. 73',6'-Dihydroxyfluoran
16 more reported names
Japan Yellow 201D and C Yellow No. 7C.I. Solvent Yellow 94Soap Yellow FHidacid fluoresceinYellow 7FluoreszeinFluorescein RedD+C Yellow No. 711712 YellowCHEBI:31624Japan Yellow No. 201Zlut kysela 733',6'-FluorandiolKi201NSC-667256
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 518-47-8
CAS 518-47-8PubChem CID 10608

Sodium Fluorescein

Fluorescein, disodium salt is an orange-red to dark red powder. Water-soluble form of fluorescein. Odorless and almost tasteless. pH (5% solution) 7.8. May be sensitive to prolonged exposure to light and to heat. — CAMEO Chemicals

IUPAC name
disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate
Molecular formula
C20H10Na2O5
Molecular weight
376.3 g/mol
Exact mass
376.03236198 Da
Topological polar surface area
89.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Covalent units
3
Defined stereocentres
0

Also known as

Fluorescein disodium saltSoluble fluoresceinUraninUranine WSSResorcinol phthalein sodiumUranine YellowAk-FluorFluorescein, soluble
16 more reported names
Ki202Sodium fluoresceinateFluoresceinum natricum93X55PE38XD&C Yellow No. 8Funduscein-25Ki202(1)Ki202(2)D & C Yellow no. 8disodium 2-(6-oxido-3-oxo-3H-xanthen-9-yl)benzoateCI 45350CI 45350 (Na salt)3',6'-Dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, disodium saltRetinofluorGlostripsBioglo
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 6417-85-2
CAS 6417-85-2PubChem CID 80878

Fluorescein dipotassium

IUPAC name
dipotassium;3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate
Molecular formula
C20H10K2O5
Molecular weight
408.5 g/mol
Exact mass
407.98023638 Da
Topological polar surface area
81.7 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Covalent units
3
Defined stereocentres
0

Also known as

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-, dipotassium saltFluorescein, Dipotassium SaltUNII-Z6551U35SAZ6551U35SAEINECS 229-143-9Dipotassium 2-(6-oxido-3-oxoxanthen-9-yl)benzoateSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-, dipotassium saltSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-, potassium salt (1:2)
10 more reported names
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-, potassium salt (1:2)RefChem:200981DIPOTASSIUM FLUORESCEINUranine Kdipotassium 3-oxo-3h-spiro[2-benzofuran-1,9'-xanthene]-3',6'-diolatePotassium 3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-bis(olate)Potassium fluoresceinURANINEKDZSPMLRDMGJVAT-UHFFFAOYSA-LDipotassium 3-oxo-3H-spiro[[2]benzofuran-1,9'-xanthene]-3',6'-bis(olate)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CI 45350

INCI name

CI 45350

INN name

fluorescein sodium

Description

Disodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate

Record provenance

Inventory reference
32767
Imported identity
CI 45350
Source update
14/08/2020
European Commission CosIng source notes
Annex IV Restriction reference
Entry 74

CI 45350

CAS: 518-45-6; 518-47-8
EC: -; 208-253-0

Key data

CAS
518-47-8 / 2321-07-5 / 6417-85-2
EC
208-253-0 / 219-031-8 / 229-143-9
Restriction
IV/74 (CI 45350) II/1332 (Acid Yellow 73 sodium salt; CI 45350) when used as a substance in hair dye products
Function
COLORANT
Exclusively or mainly intended to colour the cosmetic product, the body as a whole or certain parts thereof, by absorption or reflection of visible light. All authorised colorants are substances in the positive list of Annex IV to the Cosmetics Regulation 1223/2009.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#6412 · CI 45350

Ingredients with overlapping formulation functions

CI 44090COLORANT
CI 45100COLORANT, HAIR DYEING
CI 45190COLORANT
CI 45220COLORANT
CI 45370COLORANT
CI 45380COLORANT
CI 45396COLORANT
CI 45405COLORANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How CI 45350 appears in the CosIng inventory

The CosIng inventory lists CI 45350 as a cosmetic ingredient and this page links it to 2 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CI 45350 is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CI 45350 appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for CI 45350 reads: "IV/74 (CI 45350) II/1332 (Acid Yellow 73 sodium salt; CI 45350) when used as a substance in hair dye products". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, CI 45350 carries the following function designation(s):

CAS 518-47-8 / 2321-07-5 / 6417-85-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CI 45350

This page combines the CosIng inventory entry for CI 45350 with 2 linked Annex II–VI records from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research CI 45350 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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