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InventoryRef 3276814/08/2020

CI 45370

4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one

CI 45370 is linked to 2 EU annex records on this page. Inventory note: IV/75 (CI 45370) II/1333 (Solvent Red 72) and its disodium salt (CI 45370) when used as a substance in hair dye products.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Prohibited entry found
Open this evidence		2English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilEvidence linked
Prohibited
Open this evidence		1Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 4372-02-5
CAS 4372-02-5PubChem CID 20388

Solvent Red 72

IUPAC name
disodium;4',5'-dibromo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate
Molecular formula
C20H8Br2Na2O5
Molecular weight
534.1 g/mol
Exact mass
533.85134 Da
Topological polar surface area
81.7 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Covalent units
3
Defined stereocentres
0

Also known as

DibromofluoresceinC.I. Acid Orange 11Eosine 2JBromo Acid YellowishEosine S 104',5'-DibromfluoresceinD and C Orange No. 6C.I. 45370
16 more reported names
EINECS 224-468-27MF02AWG95Fluorescein, 4',5'-dibromo-, disodium saltFluorescein, 4',5'-dibromo-, sodium deriv., sodium saltSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 4',5'-dibromo-3',6'-dihydroxy-, disodium saltSpiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-, disodium saltRefChem:888153SOLVENT RED 72 [INCI]CI 45370 [INCI]BENZOIC ACID, 2-(4,5-DIBROMO-6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-, DISODIUM SALTBENZOIC ACID, 2-(4,5-DIBROMO-6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-, SODIUM SALT (1:2)CI 45370ORANGE NO. 201SPIRO(ISOBENZOFURAN-1(3H),9'-(9H)XANTHEN)-3-ONE, 4',5'-DIBROMO-3',6'-DIHYDROXY-, SODIUM SALT (1:2)Acid orange 11UNII-7MF02AWG95
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 596-03-2
CAS 596-03-2PubChem CID 11689

D & C Orange No. 5

IUPAC name
4',5'-dibromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
Molecular formula
C20H10Br2O5
Molecular weight
490.1 g/mol
Exact mass
489.88745 Da
XLogP3
4.8
Topological polar surface area
76.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

4',5'-DibromofluoresceinEosinic acidJapan Orange 201D&C Orange No. 54',5'-DibromofluororesceinC.I. 45370:1CCRIS 4900DAIDAI201
16 more reported names
EINECS 209-876-0BRN 00571895P3H5X9X4QJapan Orange No. 2014',5'-Dibromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one5-19-06-00462 (Beilstein Handbook Reference)orange 5Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 4',5'-dibromo-3',6'-dihydroxy-Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-4',5'-DIBROMOFLUORESCEIN [MI]4',5'-Dibromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, disodium salt4',5'-dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-oneRefChem:581446DC ORANGE NO. 5ORANGE 5 [INCI]DAIDAI201 [INCI]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CI 45370

INCI name

CI 45370

Description

4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one

Record provenance

Inventory reference
32768
Imported identity
CI 45370
Source update
14/08/2020
European Commission CosIng source notes
Annex IV Restriction reference
Entry 75

CI 45370

CAS: 596-03-2; 4372-02-5
EC: 209-876-0; 224-468-2

Key data

CAS
4372-02-5 / 596-03-2
EC
224-468-2 / 209-876-0
Restriction
IV/75 (CI 45370) II/1333 (Solvent Red 72) and its disodium salt (CI 45370) when used as a substance in hair dye products
Function
COLORANT
Exclusively or mainly intended to colour the cosmetic product, the body as a whole or certain parts thereof, by absorption or reflection of visible light. All authorised colorants are substances in the positive list of Annex IV to the Cosmetics Regulation 1223/2009.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#6413 · CI 45370

Ingredients with overlapping formulation functions

CI 45100COLORANT, HAIR DYEING
CI 45190COLORANT
CI 45220COLORANT
CI 45350COLORANT
CI 45380COLORANT
CI 45396COLORANT
CI 45405COLORANT
CI 45410COLORANT, HAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How CI 45370 appears in the CosIng inventory

The CosIng inventory lists CI 45370 as a cosmetic ingredient and this page links it to 2 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CI 45370 is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CI 45370 appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for CI 45370 reads: "IV/75 (CI 45370) II/1333 (Solvent Red 72) and its disodium salt (CI 45370) when used as a substance in hair dye products". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, CI 45370 carries the following function designation(s):

CAS 4372-02-5 / 596-03-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
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Source note for CI 45370

This page combines the CosIng inventory entry for CI 45370 with 2 linked Annex II–VI records from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research CI 45370 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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