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Annex IV Entry 76 12/08/2020

Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments

CI 45380 / ACID RED 87

Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments appears in Annex IV as a positive-list colorant entry for EU cosmetics.

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Permitted colorant— Annex IV, EU Regulation 1223/2009
Entry: 76

Chemical identity and properties

PubChem 2D chemical structure for CAS 15086-94-9
CAS 15086-94-9PubChem CID 27020

2',4',5',7'-Tetrabromofluorescein

Bromoeosin is an organobromine compound. It is functionally related to a fluorescein (lactone form). — ChEBI

IUPAC name
2',4',5',7'-tetrabromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
Molecular formula
C20H8Br4O5
Molecular weight
647.9 g/mol
Exact mass
647.70642 Da
XLogP3
6.2
Topological polar surface area
76.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

C.I. Solvent Red 43C.I. 45380:23,6-Dihydroxy-2,4,5,7-tetrabromospiro(xanthene-9,3'-phthalide)CI 45380:2NSC-244436Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-2',4',5',7'-tetrabromo-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-oneSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-
16 more reported names
2',4',5',7'-TETRABROMO-3',6'-DIHYDROXY-3H-SPIRO(2-BENZOFURAN-1,9'-XANTHEN)-3-ONE2',4',5',7'-tetrabromo-3',6'-dihydroxyspiro(2-benzofuran-3,9'-xanthene)-1-oneRefChem:1058590CHEBI:86277Solvent Red 43BromoeosinBromeosinEosine acidEosin acidJapan Red 223Japan Red No. 223Eosin Y free acidD and C Red No. 21D & C Red no. 21Acid eosinD&C Red No. 21
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 17372-87-1
CAS 17372-87-1PubChem CID 11048

Eosin

Eosin YS dye is an organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions. It has a role as a fluorochrome and a histological dye. It is an organobromine compound and an organic sodium salt. It contains a 2',4',5',7'-tetrabromofluorescein(2-). — ChEBI

IUPAC name
disodium;2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate
Molecular formula
C20H6Br4Na2O5
Molecular weight
691.9 g/mol
Exact mass
691.67031 Da
Topological polar surface area
89.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Covalent units
3
Defined stereocentres
0

Also known as

Acid red 87Eosin yellowishEosine YellowishEosineEosine GEosin YSSodium eosineBromo acid
16 more reported names
Eosine YBromofluoresceinSodium eosinateBronze BromoCertiqual EosineBromo FluoresceinEosine AEosine JEosine BSEosine DAEosine FAEosine GFEosine OJEosine w/sEosine YBEosine YS
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 94021-89-3
CAS 94021-89-3PubChem CID 44146772

2-(2,4,5,7-tetrabromo-3,6-dihydroxyxanthen-9-yl)benzoic acid, zirconium salt

IUPAC name
tetrakis(2-(2,4,5,7-tetrabromo-3,6-dihydroxy-9H-xanthen-9-yl)benzoate);zirconium(4+)
Molecular formula
C80H36Br16O20Zr
Molecular weight
2686.8 g/mol
Exact mass
2684.7617 Da
Topological polar surface area
359.0 Ų
Hydrogen-bond donors
8
Hydrogen-bond acceptors
20
Covalent units
5
Defined stereocentres
0

Also known as

EINECS 301-481-2RefChem:83900301-481-2Zirconium(4+) tetrakis[2-(2,4,5,7-tetrabromo-3,6-dihydroxy-9H-xanthen-9-yl)benzoate]
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Warnings

Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid

Colour index or glossary

CI 45380 / ACID RED 87

Chemical name

Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments

Chemical / IUPAC name

Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments

Color

Red

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

Key data

CAS
17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3
EC
241-409-6 / - / 240-005-7 / 239-138-3 / 301-481-2
Annex
IV
Entry number
76

Inventory links for Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments

Inventory Identified ingredient
Ref 31631

ACID RED 87

CAS: 17372-87-1; 548-26-5
EC: 241-409-6
Inventory Restriction reference
Ref 32769

CI 45380

CAS: 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3
EC: 241-409-6 / - / 240-005-7 / 239-138-3 / 301-481-2

Direct matches are limited for this record, so nearby entries from Annex IV are shown as well.

Annex IV 75
Nearby record in the same annex

CI 45370

CAS: 596-03-2; 4372-02-5
EC: 209-876-0; 224-468-2
Annex IV 77
Nearby record in the same annex

CI 45396

CAS: 24545-86-6
EC: 246-308-0
Annex IV 74
Nearby record in the same annex

CI 45350

CAS: 518-45-6; 518-47-8
EC: -; 208-253-0
Annex IV 78
Nearby record in the same annex

CI 45405

CAS: 6441-77-6
EC: 229-225-4
Annex IV 73
Nearby record in the same annex

CI 45220

CAS: 5873-16-5
EC: 227-528-6
Annex IV 79
Nearby record in the same annex

CI 45410

CAS: 18472-87-2
EC: 242-355-6
Annex IV 80
Nearby record in the same annex

CI 45430

CAS: 12227-78-0
EC: 240-474-8
Annex IV 70
Nearby record in the same annex

CI 44090

CAS: 3087-16-9
EC: 221-409-2

What Annex IV means for Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments

Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments is an approved colorant listed in Annex IV of EU Cosmetics Regulation 1223/2009. Only colorants on this positive list may be used to colour cosmetic products on the EU market.

Some colorants in Annex IV are restricted by product type — for example, prohibited from use around the eyes or in products applied to mucous membranes. Check the product type and conditions fields above before use.

This record is linked to 3 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Confirm colorant is used only in permitted product types listed above.
  • Record the Colour Index number and CAS identifier in the ingredient declaration.

Frequently asked questions

Yes. Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments is included in Annex IV of EU Cosmetics Regulation 1223/2009 as a permitted colorant. Only colorants on this positive list may be used to colour cosmetic products in the EU. Check the product type conditions above for any use restrictions.

CAS 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3 is the unique numerical identifier assigned to Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex IV record Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments

This page summarizes one Annex IV record for Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex IV conditions for Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments, but confirm any final regulatory decision against the current official annex wording and source files.

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