Official EU label nameGlossary entry 6413

CI 45370

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 6 of 13 indexed market datasets: 8 country records and 1 EU Annex records. Every result and evidence gap is listed below.

6 markets with evidence

Markets checked

Markets with evidence

Evidence gaps

Resolved identifiers

A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.

Resolved substance identity

CAS:4372-02-5596-03-215086-94-917372-87-115876-39-8

EC:224-468-2209-876-0240-005-7

Ingredient index records:

CI 45370

Cosmetic functions: COLORANT

4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one

Inventory restriction note: IV/75 (CI 45370) II/1333 (Solvent Red 72) and its disodium salt (CI 45370) when used as a substance in hair dye products

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SOLVENT RED 72

Cosmetic functions: COLORANT, HAIR DYEING

4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one (CI 45370)

Inventory restriction note: II/1333 (when used as a substance in hair dye products)

Open full local profile

10 matched or reported names

CI 45370SOLVENT RED 724',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments (Solvent Red 72)4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one (4',5'-dibromofluorescein; Solvent Red 72) and its disodium salt (CI 45370) when used as a substance in hair dye products4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-4',5'-dibromo-3',6'-dihidroxiespiro[isobe nzofurano-1(3H),9'-[9H]xanteno]-3-ona; 4',5'-dibromofluoresceina (Solvente Vermelho 72) e seu sal sódico (CI 45370), quando usado como substância que entra na composição de corantes capilaresin hair dye products 4 ,5 -Dibromo-3 -dihydroxyspiro[isobenzofuran- -[9H]xanthene]-3- - ’ ’ ’,6’ 1(3H),9’ one; 4’,5’ Dibromofluorescein; (solvent red 72) ( CAS No. 596-03-2) and its disodium salt (CI 45370) (CAS No.4372-02-5) when used as a substance in hair dye products 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)- -tetrabromo- benzoic acid; Fluorescein, 2’,4’,5’,7’ (solvent red 43) (CAS No. 15086-94-9), its disodium salt (acid red 87; CI 45380) (CAS No. 17372-87-1)and its aluminium salt (pigment red 90 : 1 aluminium lake) (CAS No. 15876-39-8) when used as a4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one; 4',5'-Dibromofluorescein; (Solvent Red 72) and its disodium salt (CI 45370) when used as a substance in hair dye products

Regulatory evidence in all 13 markets

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Market	Result	Records	Dataset	Meaning / next action
European Union EU	Conditional positive-list match	1Open record 1	Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026	Review every linked record and exact conditions.
Great Britain GB	No local match	0	Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026	No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.
Canada CA	No local match	0	Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025	The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand NZ	Prohibited	3Open record 1 Open record 2	Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026	Review every linked record and exact conditions.
ASEAN ASEAN	Prohibited	1Open record 1	Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026	Review every linked record and exact conditions.
China CN	No local match	0	Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025	IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan JP	No local match	0	Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot	The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea KR	No local match	0	Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026	Korean source wording is canonical and other positive lists/notices may still apply to the formulation.
United States US	No local match	0	Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026	FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia AU	No local match	0	Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026	An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil BR	Prohibited	1Open record 1	Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026	Review every linked record and exact conditions.
India IN	Prohibited	2Open record 1 Open record 2	Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)	Review every linked record and exact conditions.
Saudi Arabia SA	Prohibited	1Open record 1	Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026	Review every linked record and exact conditions.

Matching market records and conditions

European Union

Regulation (EC) 1223/2009 consolidated to 1 May 2026

CI 45370Annex IV

New Zealand

Cosmetic Products Group Standard schedules effective 1 January 2026

4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments (Solvent Red 72)Permitted list with conditions

Colour index: 45370 · CAS: 596-03-2 · Colour: Orange · Other limitations: Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl) benzoic acid

Schedule 6, reference 75, source row 77 · effective-2026-01-01

4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one (4',5'-dibromofluorescein; Solvent Red 72) and its disodium salt (CI 45370) when used as a substance in hair dye productsProhibited

Schedule 4, reference 1333, source row 1404 · effective-2026-01-01

Schedule 4, reference 1333, source row 1405 · effective-2026-01-01

ASEAN

ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-Prohibited

ASEAN Annex II, reference 1333 · 2026-1

Brazil

ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026

4',5'-dibromo-3',6'-dihidroxiespiro[isobe nzofurano-1(3H),9'-[9H]xanteno]-3-ona; 4',5'-dibromofluoresceina (Solvente Vermelho 72) e seu sal sódico (CI 45370), quando usado como substância que entra na composição de corantes capilaresProhibited

RDC 529/2021 consolidated annex, entry 1333 (through RDC 1.030/2026) · RDC 529/2021 consolidated through RDC 1.030/2026

India

Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

in hair dye products 4 ,5 -Dibromo-3 -dihydroxyspiro[isobenzofuran- -[9H]xanthene]-3- - ’ ’ ’,6’ 1(3H),9’ one; 4’,5’ Dibromofluorescein; (solvent red 72) ( CAS No. 596-03-2) and its disodium salt (CI 45370) (CAS No.Prohibited

Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

IS 4707 (Part 2):2025 Annex A, entry 1306 · IS 4707 (Part 2):2025, fifth revision

4372-02-5) when used as a substance in hair dye products 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)- -tetrabromo- benzoic acid; Fluorescein, 2’,4’,5’,7’ (solvent red 43) (CAS No. 15086-94-9), its disodium salt (acid red 87; CI 45380) (CAS No. 17372-87-1)and its aluminium salt (pigment red 90 : 1 aluminium lake) (CAS No. 15876-39-8) when used as aProhibited

Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

IS 4707 (Part 2):2025 Annex A, entry 1307 · IS 4707 (Part 2):2025, fifth revision

Saudi Arabia

SFDA live prohibited/restricted lists, snapshot 30 August 2026

4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one; 4',5'-Dibromofluorescein; (Solvent Red 72) and its disodium salt (CI 45370) when used as a substance in hair dye productsProhibited

SFDA prohibited list, page 133, row 9 · live-snapshot-2026-08-30

Exact Annex II–VI evidence

Annex IVentry 75

Open full regulatory record

CI 45370

Warnings: Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid

Chemical identity and properties

PubChem 2D chemical structure for CAS 15086-94-9

CAS 15086-94-9PubChem CID 27020

2',4',5',7'-Tetrabromofluorescein

IUPAC name: 2',4',5',7'-tetrabromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one

Molecular formula: C20H8Br4O5
Molecular weight: 647.9 g/mol
Exact mass: 647.70642 Da
XLogP3: 6.2
Topological polar surface area: 76.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

C.I. Solvent Red 43C.I. 45380:23,6-Dihydroxy-2,4,5,7-tetrabromospiro(xanthene-9,3'-phthalide)CI 45380:2NSC-244436Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-2',4',5',7'-tetrabromo-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-oneSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-

16 more reported names

2',4',5',7'-TETRABROMO-3',6'-DIHYDROXY-3H-SPIRO(2-BENZOFURAN-1,9'-XANTHEN)-3-ONE2',4',5',7'-tetrabromo-3',6'-dihydroxyspiro(2-benzofuran-3,9'-xanthene)-1-oneRefChem:1058590CHEBI:86277Solvent Red 43BromoeosinBromeosinEosine acidEosin acidJapan Red 223Japan Red No. 223Eosin Y free acidD and C Red No. 21D & C Red no. 21Acid eosinD&C Red No. 21

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External database identifiers

ChEBI:CHEBI:39078
ChEMBL:CHEMBL408917
EPA DTXSID:DTXSID3044590
PubMed:18636704
PubMed:12884026

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 17372-87-1

CAS 17372-87-1PubChem CID 11048

Eosin

IUPAC name: disodium;2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate

Molecular formula: C20H6Br4Na2O5
Molecular weight: 691.9 g/mol
Exact mass: 691.67031 Da
Topological polar surface area: 89.5 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 5
Covalent units: 3
Defined stereocentres: 0

Also known as

Acid red 87Eosin yellowishEosine YellowishEosineEosine GEosin YSSodium eosineBromo acid

16 more reported names

Eosine YBromofluoresceinSodium eosinateBronze BromoCertiqual EosineBromo FluoresceinEosine AEosine JEosine BSEosine DAEosine FAEosine GFEosine OJEosine w/sEosine YBEosine YS

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External database identifiers

ChEBI:CHEBI:52053
ChEMBL:CHEMBL411675
EPA DTXSID:DTXSID901015574
PubMed:33352258

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 4372-02-5

CAS 4372-02-5PubChem CID 20388

Solvent Red 72

IUPAC name: disodium;4',5'-dibromo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate

Molecular formula: C20H8Br2Na2O5
Molecular weight: 534.1 g/mol
Exact mass: 533.85134 Da
Topological polar surface area: 81.7 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 5
Covalent units: 3
Defined stereocentres: 0

Also known as

DibromofluoresceinC.I. Acid Orange 11Eosine 2JBromo Acid YellowishEosine S 104',5'-DibromfluoresceinD and C Orange No. 6C.I. 45370

16 more reported names

EINECS 224-468-27MF02AWG95Fluorescein, 4',5'-dibromo-, disodium saltFluorescein, 4',5'-dibromo-, sodium deriv., sodium saltSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 4',5'-dibromo-3',6'-dihydroxy-, disodium saltSpiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-, disodium saltRefChem:888153SOLVENT RED 72 [INCI]CI 45370 [INCI]BENZOIC ACID, 2-(4,5-DIBROMO-6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-, DISODIUM SALTBENZOIC ACID, 2-(4,5-DIBROMO-6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-, SODIUM SALT (1:2)CI 45370ORANGE NO. 201SPIRO(ISOBENZOFURAN-1(3H),9'-(9H)XANTHEN)-3-ONE, 4',5'-DIBROMO-3',6'-DIHYDROXY-, SODIUM SALT (1:2)Acid orange 11UNII-7MF02AWG95

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External database identifiers

EPA DTXSID:DTXSID40933520

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 596-03-2

CAS 596-03-2PubChem CID 11689

D & C Orange No. 5

IUPAC name: 4',5'-dibromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one

Molecular formula: C20H10Br2O5
Molecular weight: 490.1 g/mol
Exact mass: 489.88745 Da
XLogP3: 4.8
Topological polar surface area: 76.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

4',5'-DibromofluoresceinEosinic acidJapan Orange 201D&C Orange No. 54',5'-DibromofluororesceinC.I. 45370:1CCRIS 4900DAIDAI201

16 more reported names

EINECS 209-876-0BRN 00571895P3H5X9X4QJapan Orange No. 2014',5'-Dibromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one5-19-06-00462 (Beilstein Handbook Reference)orange 5Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 4',5'-dibromo-3',6'-dihydroxy-Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-4',5'-DIBROMOFLUORESCEIN [MI]4',5'-Dibromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, disodium salt4',5'-dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-oneRefChem:581446DC ORANGE NO. 5ORANGE 5 [INCI]DAIDAI201 [INCI]

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External database identifiers

ChEMBL:CHEMBL3561473
EPA DTXSID:DTXSID7024904

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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