What is CAS 38083-17-9; for CLIMBAZOLE?

CAS 38083-17-9; is the unique numerical identifier assigned to CLIMBAZOLE by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

How is the maximum concentration of CLIMBAZOLE calculated in a finished product?

The maximum concentration of 2,0 % applies to the substance in the ready-to-use cosmetic product. When supplied as part of a blend or mixture, the calculation must account for contributions from all sources in the formulation.

Annex III Entry 310 28/07/2020

CLIMBAZOLE

Q: How do I check if my product formula contains CLIMBAZOLE?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

CLIMBAZOLE is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 2,0 %.

Restricted substance— Annex III, EU Regulation 1223/2009

Max conc.: 2,0 %

Entry: 310

Reading this entry

Climbazole appears in two annexes at once. As a preservative it is Annex V entry 32, at 0.2% to 0.5% depending on the product; this entry covers anti-dandruff use at 2.0%, which is ten times higher.

Rinse-off anti-dandruff shampoo: 2.0%, for purposes other than preserving the product.
As a preservative it is Annex V entry 32: 0.2% in hair lotions, face creams and foot care, 0.5% in rinse-off shampoo.
The purpose must be apparent from how the product is presented — the claim decides which entry applies.
A shampoo claiming anti-dandruff action and one merely containing climbazole are answering different entries.

Climbazole is the clearest example on this site of a substance whose limit depends on why it is there. Used to keep a formulation from spoiling, it is a preservative and Annex V entry 32 applies: 0.2% in hair lotions, face creams and foot care products, 0.5% in rinse-off shampoo. Used as an active against dandruff, this Annex III entry applies and permits 2.0% in rinse-off anti-dandruff shampoo.

The regulation resolves which one governs by looking at the product rather than the formula. The entry requires that the purpose be apparent from the presentation of the product — the claim, the naming, the way it is sold. Two shampoos with identical climbazole content can therefore be answering different entries, and the one making the anti-dandruff claim is the one entitled to the higher limit.

This is the same mechanism as salicylic acid, and it is worth recognising as a pattern: where a substance can both preserve and act, the annexes split it by purpose, and the marketing copy becomes part of the compliance answer.

Checked against

Regulation (EU) 2019/698 (EUR-Lex)

Chemical identity and properties

PubChem 2D chemical structure for CAS 38083-17-9

CAS 38083-17-9PubChem CID 37907

Climbazole

1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a hemiaminal ether, a ketone, a member of imidazoles, an aromatic ether and a member of monochlorobenzenes. — ChEBI

IUPAC name: 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one

Molecular formula: C15H17ClN2O2
Molecular weight: 292.76 g/mol
Exact mass: 292.0978555 Da
XLogP3: 3.7
Topological polar surface area: 44.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

ClimbazolBaypivalCrinipan ADBAY-E 6975BaysanClimbazolum2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-NSC-759808

16 more reported names

9N42CW7I541-(p-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone(RS)-1-(4-CHLOROPHENOXY)-1-IMIDAZOL-1-YL-3,3-DIMETHYLBUTAN-2-ONERefChem:577718CHEBI:83499253-775-41-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one1-(4-Clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanoneClimbazol [INN-Spanish]Climbazolum [INN-Latin]CAS-38083-17-9Climbazole [INN:BAN]EINECS 253-775-4BRN 0618020Bay e 6975

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:83719
ChEMBL:CHEMBL1437764
EPA DTXSID:DTXSID6046555
PubMed:38795739
PubMed:21272039
PubMed:11824557
PubMed:11552297
PubMed:11534318

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

2,0 %

Product type

Rinse-off anti-dandruff shampoo

Other restrictions

For purposes other than inhibiting the development of micro-organisms in the product. This purpose has to be apparent from the presentation of the product.

INCI glossary name

CLIMBAZOLE

Chemical name

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

Chemical / IUPAC name

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

Regulatory information

Regulation

(EU) 2019/698

See every entry this act set

SCCS opinions

Key data

CAS

38083-17-9;

253-775-4;

Annex

III

Entry number

310

Inventory links for CLIMBAZOLE

Inventory Shared INCI name

Ref 32909

CLIMBAZOLE

CAS: 38083-17-9

EC: 253-775-4

Direct matches are limited for this record, so nearby entries from Annex III are shown as well.

Annex V 32

Shared CAS number