Annex III Source last update: 02/03/2026

Restricted cosmetic substances

LIST OF SUBSTANCES WHICH COSMETIC PRODUCTS MUST NOT CONTAIN EXCEPT SUBJECT TO THE RESTRICTIONS LAID DOWN

Records on this page set

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Use these pages for research, discovery and comparison, but verify critical regulatory decisions against the official source text and current law.

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Records

373 total

Entry

288

HC Blue No 17

3-[(4-amino-3- methyl-9,10-dioxo-9,10-dihydroanthracen-1- yl)amino]-N,N,N -trimethylpropan-1-aminium, methylsulfate salt

(a) To be printed on the label: The mixing ratio Hair colorants can cause severe allergic reactions. Read and folow instructions. This product is not intended for use on persons under the age of 16. Temporary "black hen…

CAS

16517-75-2

605-392-2

Max concentration Product type 05/08/2015

Entry

289

HC BLUE NO 15

Phosphoric acid compound with 4-[(2,6-dichlorophenyl) (4-imino- 3,5-dimethyl-2,5- cyclohexadien-1- ylidene) methyl]- 2,6-dimethylaniline (1:1)

(a) To be printed on the label: The mixing ratio Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary "black h…

CAS

74578-10-2

277-929-5

Max concentration Product type 05/08/2015

Entry

Calcium monofluorophosphate

Contains calcium monofluorophosphate. For any toothpaste with compounds containing fluorine in a concentration of 0,1 to 0,15 % calculated as F unless it is already labelled as contra-indicated for children (e.g. “for …

CAS

7789-74-4

232-187-1

Max concentration Product type 14/05/2013

Entry

290

ACID GREEN 25

Disodium 2,2′- (9,10-dioxoanthracene-1,4-diyldiimino)bis(5- methylsulphonate)

Hair dye substance in non-oxidative hair dye products

CAS

4403-90-1

224-546-6

Max concentration Product type 05/08/2015

Entry

291

ACID VIOLET 43

Sodium, 4- [(9,10-dihydro-4- hydroxy-9,10-dioxo-1-anthryl) amino]toluene-3- sulphonate

Hair dye substance in non-oxidative hair dye products

CAS

4430-18-6

224-618-7

Max concentration Product type 12/08/2020

Entry

292

2-METHOXYMETHYL-P-PHENYLENEDIAMINE /2-METHOXYMETHYL-P-PHENYLENEDIAMINE SULFATE

1,4-Benzenediamine, 2-(methoxymethyl) 1,4-Benzenediamine, 2-(methoxymethyl)-, sulfate

(a) To be printed on the label: The mixing ratio. ‘! Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “b…

CAS

337906-36-2 ; 337906-37-3

679-526-3; 638-749-6

Product type 23/11/2020

Entry

293

Hydroxyanthraquinone-aminopropyl Methyl Morpholinium Methosulfate

1-N-Methylmorpholiniumpropylamino-4-hydroxyanthraquinone, methyl sulfate

To be printed on the label: “Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may …

CAS

38866-20-5

254-161-9

Max concentration Product type 05/08/2015

Entry

294

Disperse Red 17

Ethanol, 2,2′-[[3- methyl-4-[(E)-(4- nitrophenyl)azo] phenyl]imino]bis-

(a)To be printed on the label: The mixing ratio. “Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black…

CAS

3179-89-3

221-665-5

Max concentration Product type 05/08/2015

Entry

295

Acid Black 1

4-Amino-5-hydroxy-3-(4-nitrophenylazo)-6- (phenylazo)-2,7- naphthalenedisulfonic acid, disodium salt

Hair dye substance in non-oxidative hair dye products

CAS

1064-48-8

213-903-1

Max concentration Product type 05/08/2015

Entry

296

Pigment Red 57

Disodium 3-hydroxy-4-[(E)-(4- methyl-2-sulfonatophenyl)diazenyl]-2-naphthoate

Hair dye substance in non-oxidative hair dye products

CAS

5858-81-1

227-497-9

Max concentration Product type 05/08/2015

Entry

297

ETHOXYDIGLYCOL

2-(2-ethoxyethoxy)ethanol Diethylene Glycol Monoethyl Ether (DEGEE), Ethoxydiglycol

(a) to (e): The level of ethylene glycol impurity in Ethoxydiglycol must be ≤ 0,1 %. Not to be used in eye products and oral products

CAS

111-90-0

203-919-7

Max concentration Product type 24/10/2018

Entry

298

HC RED NO 17

Di[2-[4-[(E)-2-[4- [bis(2-hydroxyethyl)aminophenyl]vinyl]pyridin-1- ium] butanoyl]aminoethyl]di-sulfanyl dichloride

As from 3 September 2017: — Do not use with nitrosating agents — Maximum nitrosamine content: 50 μg/kg — Keep in nitrite-free containers

CAS

1449471-67-3

—

Max concentration Product type 27/07/2020

Entry

299

HC YELLOW NO 17

Di[2-[4-[(E)-2- [2,4,5-trimethoxyphenyl]vinyl]pyridinin-1-ium]butanoyl]aminoethyl]disulfanyl dichloride

As from 3 March 2018: “Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increa…

CAS

1450801-55-4

—

Max concentration Product type 27/07/2020

Entry

THIOGLYCOLIC ACID

Thioglycolic acid and its salts

Conditions of use: (a) (b) (c) (d) Avoid contact with eyes Rinse eyes immediately if product comes into contact with them. (a) (c) (d) Wear suitable gloves Warnings to be printed on the label: (a)(i) (b) (c) Contains…

CAS

68-11-1

200-677-4

Max concentration Product type 27/07/2020

Entry

Thioglycolic acid esters

Conditions of use: (a) (b) May cause sensitization in the event of skin contact Avoid contact with eyes In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice Wear suitable …

CAS

—

Max concentration Product type 17/10/2010

Entry

OXALIC ACID

Oxalic acid, its esters and alkaline salts

For professional use only

CAS

144-62-7

205-634-3

Max concentration Product type 17/10/2010

Entry

Calcium fluoride

Contains calcium fluoride For any toothpaste with compounds containing fluorine in a concentration of 0.1 to 0.15% calculated as F unless it is already labelled as contra-indicated for children (e.g. "for adult use onl…

CAS

7789-75-5

232-188-7

Max concentration Product type 14/05/2013

Entry

300

1-HEXYL 4,5-DIAMINO PYRAZOLE SULFATE

1H-Pyrazole-4,5- diamine, 1-hexyl-, sulfate (2:1)

As from 3 March 2018, to be printed on the label: The mixing ratio. ‘Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16…

CAS

1361000-03-4

—

Product type 27/07/2020

Entry

301

2,5,6-TRIAMINO- 4-PYRIMIDINOL SULFATE

4-Hydroxy-2,5,6- triaminopyrimidine sulfate

As from 3 March 2018, to be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 1…

CAS

1603-02-7

216-500-9

Product type 27/07/2020

Entry

302

HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL

2-[(3-Aminopyrazolo[1,5-a]pyridin-2- yl)oxy]ethanol hydrochloride

CAS

1079221-49-0

695-745-7

Product type 27/07/2020

Entry

303

3-AMINO-2,6- DIMETHYLPHENOL

Phenol, 3-amino-2,6- dimethyl

As from 3 March 2018, to be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 1…

CAS

6994-64-5

230-268-6

Product type 27/07/2020

Entry

304

BASIC BROWN 17

2-Naphthalenaminium, 8-[(4- amino-3-nitrophenyl)azo]-7-hydroxy- N,N,N-trimethyl-, chloride

Hair dye substance in non-oxidative hair dye products

CAS

68391-32-2

269-944-0

Max concentration Product type 27/07/2020

Entry

305

BASIC BLUE 124

3-Amino-7- (dimethylamino)-2- methoxyphenoxazin- 5-ium chloride

As from 3 March 2018: ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increas…

CAS

67846-56-4

267-370-5

Max concentration Product type 27/07/2020

Entry

306

ARACHIS HYPOGAEA OIL; ARACHIS HYPOGAEA SEEDCOAT EXTRACT; ARACHIS HYPOGAEA FLOUR; ARACHIS HYPOGAEA FRUIT EXTRACT; ARACHIS HYPOGAEA SPROUT EXTRACT; HYDROGENATED …

Peanut oil, extracts and derivatives

Maximum concentration of peanut proteins: 0,5 ppm (22 )

CAS

8002-03-7; 68425-36; 91051; 91744-77-3; 68440-49-3; 93572-05-5; 61789-56-8; 61789-57-9; 73138-79-1

232-296-4; 270-350-9; 293-087-1; 294-643-6; -; 297-433-2; 263-069-8; 263-070-3; 277-298-6

27/07/2020

Entry

307

HYDROLYZED WHEAT PROTEIN

Hydrolyzed wheat protein

Maximum molecular weight average of the peptides in hydrolysates: 3,5 kDa (23 )

CAS

94350-06-8 / 222400-28-4 / 70084-87-6 / 100209- 50-5

305-225-0/ -/ 309-358-5

27/07/2020

Entry

308

Tagetes minuta flower extract; Tagetes minuta flower oil

For (a) and (b): Alpha terthienyl (terthiophen) content in the extract/oil ≤ 0,35 %. For (a): Not to be used in sunscreen products and products marketed for exposure to natural/artificial UV light. For (a) and (b): In…

CAS

91770-75-1; 91770-75-1/8016-84-0

294-862-7; 294-862-7

Max concentration Product type 27/07/2020

Entry

309

Tagetes patula flower extract; Tagetes patula flower oil

CAS

91722-29-1; 91722-29-1/8016-84-0

294-431-3; 294-431-3/-

Max concentration Product type 27/07/2020

Entry

Sodium fluoride

Contains sodium fluoride For any toothpaste with compounds containing fluorine in a concentration of 0.1 to 0.15% calculated as F unless it is already labelled as contra-indicated for children (e.g. "for adult use only…

CAS

7681-49-4

231-667-8

Max concentration Product type 14/05/2013

Entry

310

CLIMBAZOLE

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

For purposes other than inhibiting the development of micro-organisms in the product. This purpose has to be apparent from the presentation of the product.

CAS

38083-17-9;

253-775-4;

Max concentration Product type 28/07/2020

Entry

312

FURFURAL

2-Furaldehyde

CAS

98-01-1

202-627-7

Max concentration CMR 26/11/2020

Entry

313

HEMA

2-Hydroxyethyl Methacrylate

For professional use only. Can cause an allergic reaction.

CAS

868-77-9

212-782-2

Product type 24/11/2020

Entry

314

DI-HEMA TRIMETHYLHEXYL DICARBAMATE

11,14-Dioxa-2,9-diazaheptadec-16-enoic Acid, 4,4,6,16-tetramethyl-10,15-dioxo, 2-[(2-methyl-1-oxo-2-propenyl)oxy]ethyl ester

For professional use only. Can cause an allergic reaction.

CAS

41137-60-4 / 72869-86-4

255-239-5 / 276-957-5

Product type 24/11/2020

Entry

315

DIMETHYLPIPERAZINIUM AMINOPYRAZOLOPYRIDINE HCL

4-(3-aminopyrazolo[1,5-A]pyridin-2-yl)-1,1-dimethylpiperazin-1-ium chloride hydrochloride

As from 3 December 2021, to be printed on the label: The mixing ratio. ‘! Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age …

CAS

1256553-33-9

813-255-5

Product type 24/11/2020

Entry

316

METHYLIMIDAZOLIUMPROPYL P-PHENYLENEDIAMINE HCL

1-(3-((4-Aminophenyl)amino)propyl)-3-methyl-1H-imidazol-3-ium chloride hydrochloride

CAS

220158-86-1

—

Product type 24/11/2020

Entry

317

HC Orange No. 6

Di-[2-[(E)-2-[4-[bis(2-hydroxyethyl)aminophenyl]vinyl]pyridin-1-ium]-ethyl]disulphide dimethanesulfonate

Methanesulfonates impurities, in particular ethyl methanesulfonate shall not be present.

CAS

1449653-83-1

—

Max concentration Product type 24/11/2020

Entry

318

ACID ORANGE 7

Sodium 4-[(2-hydroxy-1-naphthyl)azo]benzene sulfonate

Hair dye substance in non-oxidative hair dye products.

CAS

633-96-5

211-199-0

Max concentration Product type 24/11/2020

Entry

319

TETRABROMOPHENOL BLUE

Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-

(a) As from 3 December 2021, to be printed on the label: The mixing ratio. ‘Image 5 Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons u…

CAS

4430-25-5

224-622-9

Max concentration Product type 24/11/2020

Entry

POTASSIUM FLUORIDE

Potassium fluoride

Contains potassium fluoride For any toothpaste with compounds containing fluorine in a concentration of 0.1 to 0.15% calculated as F unless it is already labelled as contra-indicated for children (e.g. "for adult use o…

CAS

7789-23-3

232-151-5

Max concentration Product type 14/05/2013

Entry

320

INDIGOFERA TINCTORIA LEAF; INDIGOFERA TINCTORIA LEAF POWDER; INDIGOFERA TINCTORIA LEAF EXTRACT; INDIGOFERA TINCTORIA EXTRACT

Indigofera tinctoria, dried and pulverised leaves of Indigofera tinctoria L

Hair dye substance in non-oxidative hair dye products.

CAS

84775-63-3

283-892-6

Max concentration Product type 24/11/2020

Entry

321

TITANIUM DIOXIDE

Titanium dioxide in powder form containing 1 % or more of particles with aerodynamic diameter ≤ 10 μm

a) (b) Only in the pigmentary form (c) Not to be used in applications that may lead to exposure of the end-user’s lungs by inhalation

CAS

13463-67-7/ 1317-70-0/ 1317-80-2

236-675-5/ 215-280-1/ 215-282-2

Max concentration Product type 23/03/2022

Entry

322

DIHYDROXYACETONE

1,3-Dihydroxy-2-propanone

(a) Hair dye substance in non-oxidative hair dye products (*) (b) Self-tanning products (*) (*) From 26 January 2022 hair dye and self-tanning products containing that substance and not complying with the restrictions…

CAS

96-26-4

202-494-5

Max concentration Product type 18/10/2021

Entry

323

METHYL N-METHYLANTHRANILATE

Methyl-N-methylanthranilate

For (a): Not to be used in sunscreen products and products marketed for exposure to natural or artificial UV light. For (a) and (b): — Do not use with nitrosating agents — Maximum nitrosamine content: 50 μg/kg — Keep i…

CAS

85-91-6

201-642-6

Max concentration Product type 27/07/2022

Entry

324

METHYL SALICYLATE

Methyl 2-hydroxybenzoate

Not to be used in preparations for children under 6 years of age, with the exception of (k) “Toothpaste”. The presence of the substance shall be indicated in the list of ingredients referred to in Article 19(1), point (…

CAS

119-36-8

204-317-7

Max concentration Product type CMR 11/09/2023

Entry

325

Butylated Hydroxytoluene

2,6-Di-Tert-Butyl-4-Methylphenol

From 1 July 2023 cosmetic products containing that substance and not complying with the restrictions shall not be placed on the Union market. From 1 January 2024 cosmetic products containing that substance and not compl…

CAS

128-37-0

204-881-4

Max concentration Product type 11/11/2022

Entry

326

Acid Yellow 3

1H-Indene-1,3(2H)-dione, 2-(2-quinolinyl)-, sulfonated, sodium salts (CI 47005)

From 1 July 2023 non-oxidative hair dye products containing that substance and not complying with the restrictions shall not be placed on the Union market. From 1 January 2024 non-oxidative hair dye products containing …

CAS

8004-92-0

305-897-5

Max concentration Product type 11/11/2022

Entry

327

Acetyl Cedrene

[3R-(3α,3aβ,7β,8aα)]- 1-(2,3,4,7,8,8a- hexahydro-3,6,8,8-tetramethyl- 1H-3a,7-methanoazulen-5-yl)ethan- 1-one

The presence of the substance shall be indicated in the list of ingredients referred to in Article 19(1), point (g), when its concentration exceeds: — 0,001 % in leave-on products — 0,01 % in rinse-off products.

CAS

32388-55-9

251-020-3

03/10/2023

Entry

328

Amyl Salicylate

Pentyl-2-hydroxy- benzoate

CAS

2050-08-0

218-080-2

03/10/2023

Entry

329

Anethole

1-Methoxy-4-(1E)- 1-propen-1-yl- benzene (trans- Anethole)

CAS

104-46-1/ 4180-23-8

203-205-5/ 224-052-0

03/10/2023

Entry

AMMONIUM FLUORIDE

Ammonium fluoride

Contains ammonium fluoride. For any toothpaste with compounds containing fluorine in a concentration of 0,1 to 0,15 % calculated as F unless it is already labelled as contra-indicated for children (e.g. “for adult use …

CAS

12125-01-8

235-185-9

Max concentration Product type 14/05/2013

Entry

330

Benzaldehyde

CAS

100-52-7

202-860-4

14/09/2023

About this annex

Annex III covers substances that cosmetic products must not contain except under specific restrictions. These records often include warnings, conditions of use and concentration limits.

This section is especially useful for reviewing restricted substances, warning labels and product-type specific usage notes.