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Annex III Entry 297 24/10/2018

ETHOXYDIGLYCOL

2-(2-ethoxyethoxy)ethanol Diethylene Glycol Monoethyl Ether (DEGEE), Ethoxydiglycol

ETHOXYDIGLYCOL is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: (a) 7% (b) 5% (c) 10% (d) 2,6% (e)2,6%.

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: (a) 7% (b) 5% (c) 10% (d) 2,6% (e)2,6%
Entry: 297

Chemical identity and properties

PubChem 2D chemical structure for CAS 111-90-0
CAS 111-90-0PubChem CID 8146

Diethylene Glycol Monoethyl Ether

Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a primary alcohol, a glycol ether, a diether and a hydroxypolyether. It is functionally related to a diethylene glycol. — ChEBI

IUPAC name
2-(2-ethoxyethoxy)ethanol
Molecular formula
C6H14O3
Molecular weight
134.17 g/mol
Exact mass
134.094294304 Da
XLogP3
-0.5
Topological polar surface area
38.7 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

CARBITOLTranscutolEthoxydiglycolEthyl carbitolDioxitolEthoxy diglycolCarbitol solventSolvolsol
16 more reported names
Ethyl digolDiethylene glycol ethyl etherCarbitol cellosolveEthanol, 2-(2-ethoxyethoxy)-Losungsmittel apvDowanol DEEthyl diethylene glycolDiglycol monoethyl ether3,6-Dioxa-1-octanolDEGMEEEktasolve DEDowanol 17KarbitolEthylene diglycol monoethyl ether2-(2-Ethoxyethoxy) ethanolDiethyleneglycol monoethyl ether
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8146

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 90.4% (4397 of 4862) of all reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 4397 of 4862 companies (only 9.6% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 4862 reports by companies from 13 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 4397 of 4862 reports by companies.; There are 11 notifications provided by 465 of 4862 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H227: Combustible liquid [Warning Flammable liquids]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P260, P264, P264+P265, P270, P280, P305+P351+P338, P319, P337+P317, P370+P378, P403, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for diethylene glycol monoethyl ether(SRC), using a log Kow of -0.54(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a log Kow of -0.54(2) and a regression-derived equation(3), indicates that diethylene glycol monoethyl ether is expected to have very high mobility in soil(SRC). Volatilization of diethylene glycol monoethyl ether from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.2X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 0.126 mm Hg(4), and assigned value for water solubility of 1X10+6 mg/L (miscible)(5). Diethylene glycol monoethyl ether is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Aerobic screening test data(6-11) indicate that rapid aerobic biodegradation is likely to be the most important mechanism for the removal of diethylene glycol monoethyl ether from soil. Biodegradation of 48%(6) to 87%(7) were reported in non-acclimated cultures incubated for 20 days. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a log Kow of -0.54(2) and a regression-derived equation(3), indicates that diethylene glycol monoethyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.2X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 0.126 mm Hg(4), and assigned value for water solubility of 1X10+6 mg/L (5)(miscible). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Diethylene glycol monoethyl ether is not expected to undergo hydrolysis or direct photolysis in aquatic environments(SRC). Alcohols and ethers are generally resistant to hydrolysis(3). They do not absorb UV light in the environmental range of >290 nm and are commonly used as solvents for obtaining UV spectra(14). Aerobic screening test data(8-13) indicate that rapid aerobic biodegradation is likely to be the most important mechanism for the removal of diethylene gl Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethylene glycol monoethyl ether, which has a vapor pressure of 0.126 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethylene glycol monoethyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6.7 hours(SRC), calculated from its rate constant of 5.72X10-11 cu cm/molecule-sec at 23 °C(3). Diethylene glycol monoethyl ether does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(4). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Cleaning agent; Not Known or Reasonably Ascertainable; Coalescing agent; Laboratory chemicals; Solvent; Other; Solubility enhancer Source: EPA Chemical Data Reporting (CDR)
  • Cosmetic Ingredient Review Link: CIR ingredient: Ethoxydiglycol Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used in lubricating oil and braking fluid; [ChemIDplus] Used as a solvent for cellulose esters, lacquers, varnishes, enamels, dyestuffs, wood stains, gums, and resins; [Merck Index, 1800] Used in textile printing; [CHEMINFO] Used in photography (solvent for color processing); [www.ci.tucson.az.us/arthazards/medium.html] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Painting (Solvents) [Category: Paint]; Photographic Processing [Category: Other]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: AS SOLVENT FOR CELLULOSE ESTERS, IN LACQUER & THINNER FORMULATIONS; IN QUICK DRYING VARNISHES AND ENAMELS, FOR DYESTUFFS AND WOOD STAINS. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: A DILUENT FOR HYDRAULIC BRAKE FLUIDS; SOLVENT IN PROTECTIVE COATINGS, TEXTILE DYEING & PRINTING; SOLVENT IN COSMETICS, TOILETRIES Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Used as a chemical intermediate for the synthesis of 2-(2-ethoxyethoxy)ethyl acrylate. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Solvent for dyes, nitrocellulose, and resins; mutual solvent for mineral-oil-soap and mineral-oil-sulfonated-oil mixtures; nonaqueous stains for wood, for setting the twist and conditioning yarns and cloth; textile printing, textile soaps, lacquers, organic synthesis; brake fluid diluent. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Inert ingredient in pesticide products. Diethylene glycol monoethyl ether is found on List 2: potentially toxic other ingredients/high priority for testing inerts. ... List 2 inert ingredients are structurally similar to chemicals known to be toxic; some have data suggesting a concern. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

(a) 7% (b) 5% (c) 10% (d) 2,6% (e)2,6%

Product type

Hair dye substance in oxidative hair dye products Non-oxidative hair dye products Rinse-off products other than hair dye products Other non-spray cosmetic products The following spray products: fine fragrances, hair sprays, antiperspirant and deodorant

Other restrictions

(a) to (e):
The level of ethylene glycol impurity in Ethoxydiglycol must be ≤ 0,1 %.
Not to be used in eye products and oral products

INCI glossary name

ETHOXYDIGLYCOL

Chemical name

2-(2-ethoxyethoxy)ethanol Diethylene Glycol Monoethyl Ether (DEGEE), Ethoxydiglycol

Chemical / IUPAC name

2-(2-ethoxyethoxy)ethanol Diethylene Glycol Monoethyl Ether (DEGEE)

Regulatory information

Regulation

(EU) 2016/314

See every entry this act set

Key data

CAS
111-90-0
EC
203-919-7
Annex
III
Entry number
297

Inventory links for ETHOXYDIGLYCOL

Inventory Restriction reference
Ref 33802

ETHOXYDIGLYCOL

CAS: 111-90-0
EC: 203-919-7
Annex III 16
Shared product type

1-NAPHTHOL

CAS: 90-15-3
EC: 201-969-4
Annex III 16
Shared product type

1-Naphthol

CAS: 90-15-3
EC: 201-969-4
Annex III 193
Shared product type

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8

What Annex III means for ETHOXYDIGLYCOL

ETHOXYDIGLYCOL is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: (a) 7% (b) 5% (c) 10% (d) 2,6% (e)2,6%
  • Confirm product type compatibility: (a) Oxidative hair day products (b) Non-oxidative hair dye products (c) Rinse-off products other than hair dye products (d) Other non-spray cosmetic products (e) The following spray products: fine fragrances, hair sprays, antiperspirant and deodorant
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

ETHOXYDIGLYCOL is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 111-90-0 is the unique numerical identifier assigned to ETHOXYDIGLYCOL by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of (a) 7% (b) 5% (c) 10% (d) 2,6% (e)2,6% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record ETHOXYDIGLYCOL

This page summarizes one Annex III record for ETHOXYDIGLYCOL from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for ETHOXYDIGLYCOL, but confirm any final regulatory decision against the current official annex wording and source files.

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