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Annex III Entry 302 27/07/2020

HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL

2-[(3-Aminopyrazolo[1,5-a]pyridin-2- yl)oxy]ethanol hydrochloride

HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL is listed in Annex III and may only be used under the conditions shown in this record.

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Restricted substance— Annex III, EU Regulation 1223/2009
Entry: 302

Chemical identity and properties

PubChem 2D chemical structure for CAS 1079221-49-0
CAS 1079221-49-0PubChem CID 66922788

2-((3-Aminopyrazolo(1,5-a)pyridin-2-yl)oxy)ethanol hydrochloride (1:1)

IUPAC name
2-(3-aminopyrazolo[1,5-a]pyridin-2-yl)oxyethanol;hydrochloride
Molecular formula
C9H12ClN3O2
Molecular weight
229.66 g/mol
Exact mass
229.0618043 Da
Topological polar surface area
72.8 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
4
Covalent units
2
Defined stereocentres
0

Also known as

2-[(3-Aminopyrazolo[1,5-a]pyridin-2-yl)oxy]ethanol hydrochloride (1:1)RefChem:249296Imexine FAM2-((3-Aminopyrazolo[1,5-a]pyridin-2-yl)oxy)ethanol hydrochlorideImexine FAM; 2-(2-Hydroxyethoxy)-3-aminopyrazolo[1,5-a]pyridine hydrochloride; 2-[(3-Aminopyrazolo[1,5-a]pyridin-2-yl)oxy]ethanol hydrochloride; Imexine FAM
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match66922788

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P333+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Product type

Hair dye substance in oxidative hair dye products

Other restrictions

As from 3 September 2017, after mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 %

Warnings

As from 3 March 2018, to be printed on the label: The mixing ratio. ‘Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy.

Do not colour your hair if:
— you have a rash on your face or sensitive, irritated and damaged scalp,
— you have ever experienced any reaction after colouring your hair,
— you have experienced a reaction to a temporary “black henna” tattoo in the past.’

INCI glossary name

HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL

Chemical name

2-[(3-Aminopyrazolo[1,5-a]pyridin-2- yl)oxy]ethanol hydrochloride

Chemical / IUPAC name

2-[(3-Aminopyrazolo[1,5-a]pyridin-2- yl)oxy]ethanol hydrochloride

Regulatory information

Regulation

(EU) 2017/237

See every entry this act set

Key data

CAS
1079221-49-0
EC
695-745-7
Annex
III
Entry number
302

Inventory links for HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL

Annex III 16
Shared product type

1-NAPHTHOL

CAS: 90-15-3
EC: 201-969-4
Annex III 16
Shared product type

1-Naphthol

CAS: 90-15-3
EC: 201-969-4
Annex III 193
Shared product type

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8

What Annex III means for HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL

HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Confirm product type compatibility: Hair dye substance in oxidative hair dye products
  • Include required warning statement on product label.
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 1079221-49-0 is the unique numerical identifier assigned to HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL

This page summarizes one Annex III record for HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL, but confirm any final regulatory decision against the current official annex wording and source files.

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